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Folding@home Cores
The distributed-computing project Folding@home uses scientific computer programs, referred to as "cores" or "fahcores", to perform calculations. Folding@home's cores are based on modified and optimized versions of molecular simulation programs for calculation, including TINKER, GROMACS, AMBER, CPMD, SHARPEN, ProtoMol and Desmond. These variants are each given an arbitrary identifier (Core xx). While the same core can be used by various versions of the client, separating the core from the client enables the scientific methods to be updated automatically as needed without a client update. Active cores These cores listed below are currently used by the project. GROMACS * Core a7 ** Available for Windows, Linux, and macOS, use Advanced Vector Extensions if available, for a significant speed improvement. * Core a8 ** Available for Windows, Linux, macOS and ARM, uses Gromacs 2020.5 GPU Cores for the Graphics Processing Unit use the graphics chip of modern video cards to do mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folding@home
Folding@home (FAH or F@h) is a volunteer computing project aimed to help scientists develop new therapeutics for a variety of diseases by the means of simulating protein dynamics. This includes the process of protein folding and the movements of proteins, and is reliant on simulations run on volunteers' personal computers. Folding@home is currently based at the University of Pennsylvania and led by Greg Bowman, a former student of Vijay Pande. The project utilizes graphics processing units (GPUs), central processing units (CPUs), and ARM processors like those on the Raspberry Pi for volunteer computing and scientific research. The project uses statistical simulation methodology that is a paradigm shift from traditional computing methods. As part of the client–server model network architecture, the volunteered machines each receive pieces of a simulation (work units), complete them, and return them to the project's database servers, where the units are compiled into an overa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intel Corporation
Intel Corporation is an American multinational corporation and technology company headquartered in Santa Clara, California. It is the world's largest semiconductor chip manufacturer by revenue, and is one of the developers of the x86 series of instruction sets, the instruction sets found in most personal computers (PCs). Incorporated in Delaware, Intel ranked No. 45 in the 2020 ''Fortune'' 500 list of the largest United States corporations by total revenue for nearly a decade, from 2007 to 2016 fiscal years. Intel supplies microprocessors for computer system manufacturers such as Acer, Lenovo, HP, and Dell. Intel also manufactures motherboard chipsets, network interface controllers and integrated circuits, flash memory, graphics chips, embedded processors and other devices related to communications and computing. Intel (''int''egrated and ''el''ectronics) was founded on July 18, 1968, by semiconductor pioneers Gordon Moore (of Moore's law) and Robert Noyce (1927–19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron
The electron ( or ) is a subatomic particle with a negative one elementary electric charge. Electrons belong to the first generation of the lepton particle family, and are generally thought to be elementary particles because they have no known components or substructure. The electron's mass is approximately 1/1836 that of the proton. Quantum mechanical properties of the electron include an intrinsic angular momentum ( spin) of a half-integer value, expressed in units of the reduced Planck constant, . Being fermions, no two electrons can occupy the same quantum state, in accordance with the Pauli exclusion principle. Like all elementary particles, electrons exhibit properties of both particles and waves: They can collide with other particles and can be diffracted like light. The wave properties of electrons are easier to observe with experiments than those of other particles like neutrons and protons because electrons have a lower mass and hence a longer de Broglie wavele ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Dynamics
Molecular dynamics (MD) is a computer simulation method for analyzing the physical movements of atoms and molecules. The atoms and molecules are allowed to interact for a fixed period of time, giving a view of the dynamic "evolution" of the system. In the most common version, the trajectories of atoms and molecules are determined by numerically solving Newton's equations of motion for a system of interacting particles, where forces between the particles and their potential energies are often calculated using interatomic potentials or molecular mechanical force fields. The method is applied mostly in chemical physics, materials science, and biophysics. Because molecular systems typically consist of a vast number of particles, it is impossible to determine the properties of such complex systems analytically; MD simulation circumvents this problem by using numerical methods. However, long MD simulations are mathematically ill-conditioned, generating cumulative errors in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantum Mechanical
Quantum mechanics is a fundamental theory in physics that provides a description of the physical properties of nature at the scale of atoms and subatomic particles. It is the foundation of all quantum physics including quantum chemistry, quantum field theory, quantum technology, and quantum information science. Classical physics, the collection of theories that existed before the advent of quantum mechanics, describes many aspects of nature at an ordinary (macroscopic) scale, but is not sufficient for describing them at small (atomic and subatomic) scales. Most theories in classical physics can be derived from quantum mechanics as an approximation valid at large (macroscopic) scale. Quantum mechanics differs from classical physics in that energy, momentum, angular momentum, and other quantities of a bound system are restricted to discrete values ( quantization); objects have characteristics of both particles and waves (wave–particle duality); and there are limits to how ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ab-initio
''Ab initio'' ( ) is a Latin term meaning "from the beginning" and is derived from the Latin ''ab'' ("from") + ''initio'', ablative singular of ''initium'' ("beginning"). Etymology Circa 1600, from Latin, literally "from the beginning", from ablative case of ''initium'' "entrance", "beginning", related to verb ''inire'' "to go into", "enter upon", "begin". Uses ''Ab initio'' (abbreviation: ''ab init.'') is used in several contexts, including the following: Law In law, ''ab initio'' refers to something being the case from the start or from the instant of the act rather than from when the court declared it so. For instance, the term "void ''ab initio''" means "to be treated as invalid from the outset." E.g., in many jurisdictions, if a person signs a contract under duress, that contract is treated as being "void ''ab initio''". Typically, documents or acts which are void ''ab initio'' cannot be fixed and if a jurisdiction, a document, or an act is so declared at law to be void ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SSE2
SSE2 (Streaming SIMD Extensions 2) is one of the Intel SIMD (Single Instruction, Multiple Data) processor supplementary instruction sets first introduced by Intel with the initial version of the Pentium 4 in 2000. It extends the earlier Streaming SIMD Extensions, SSE instruction set, and is intended to fully replace MMX (instruction set), MMX. Intel extended SSE2 to create SSE3 in 2004. SSE2 added 144 new instructions to SSE, which has 70 instructions. Competing chip-maker AMD added support for SSE2 with the introduction of their Opteron and Athlon 64 ranges of x86-64, AMD64 64-bit CPUs in 2003. Features Most of the SSE2 instructions implement the integer vector operations also found in MMX. Instead of the MMX registers they use the XMM registers, which are wider and allow for significant performance improvements in specialized applications. Another advantage of replacing MMX with SSE2 is avoiding the mode switching penalty for issuing x87 instructions present in MMX because it i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parallel Tempering
Parallel tempering in physics and statistics, is a computer simulation method typically used to find the lowest free energy state of a system of many interacting particles at low temperature. That is, the one expected to be observed in reality. It addresses the problem that at high temperature one may have a stable state different from low temperature, whereas simulations at low temperature may become "stuck" in a metastable state. It does this by using the fact that the high temperature simulation may visit states typical of both stable and metastable low temperature states. More specifically, parallel tempering (also known as replica exchange MCMC sampling), is a simulation method aimed at improving the dynamic properties of Monte Carlo method simulations of physical systems, and of Markov chain Monte Carlo (MCMC) sampling methods more generally. The replica exchange method was originally devised by Swendsen and Wang then extended by Geyer and later developed, among othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Codebase
In software development, a codebase (or code base) is a collection of source code used to build a particular software system, application, or software component. Typically, a codebase includes only human-written source code files; thus, a codebase usually does not include source code files generated by tools (generated files) or binary library files (object files), as they can be built from the human-written source code. However, it generally does include configuration and property files, as they are the data necessary for the build. A codebase is typically stored in a source control repository in a version control system. A source code repository is a place where large amounts of source code are kept, either publicly or privately. Source code repositories are used most basically for backups and versioning, and on multi-developer projects to handle various source code versions and to provide aid in resolving conflicts that arise from developers submitting overlapping modificatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uniprocessor System
A uniprocessor system is defined as a computer system that has a single central processing unit that is used to execute computer tasks. As more and more modern software is able to make use of multiprocessing architectures, such as SMP and MPP, the term ''uniprocessor'' is therefore used to distinguish the class of computers where all processing tasks share a single CPU. Most desktop computer A desktop computer (often abbreviated desktop) is a personal computer designed for regular use at a single location on or near a desk due to its size and power requirements. The most common configuration has a case that houses the power supply ...s are shipped with multiprocessing architectures since the 2010s. As such, this kind of system uses a type of architecture that is based on a single computing unit. All operations (additions, multiplications, etc.) are thus done sequentially on the unit. Further reading Parallel computing {{Compu-hardware-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (microprocessor)
Cell is a multi-core microprocessor microarchitecture that combines a general-purpose PowerPC core of modest performance with streamlined coprocessing elements which greatly accelerate multimedia and vector processing applications, as well as many other forms of dedicated computation. It was developed by Sony, Toshiba, and IBM, an alliance known as "STI". The architectural design and first implementation were carried out at the STI Design Center in Austin, Texas over a four-year period beginning March 2001 on a budget reported by Sony as approaching US$400 million. Cell is shorthand for Cell Broadband Engine Architecture, commonly abbreviated ''CBEA'' in full or ''Cell BE'' in part. The first major commercial application of Cell was in Sony's PlayStation 3 game console, released in 2006. In May 2008, the Cell-based IBM Roadrunner supercomputer became the first TOP500 LINPACK sustained 1.0 petaflops system. Mercury Computer Systems also developed designs based on the Cell. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
