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Fluorescent Glucose Biosensors
Fluorescent glucose biosensors are devices that measure the concentration of glucose in diabetic patients by means of sensitive protein that relays the concentration by means of fluorescence, an alternative to amperometric sension of glucose. Due to the prevalence of diabetes, it is the prime drive in the construction of fluorescent biosensors. A recent development has been approved by the FDA allowing a new continuous glucose monitoring system called EverSense, which is a 90-day glucose monitor using fluorescent biosensors. Application Keeping glucose levels in check is crucial to minimize the onset of the damage caused by diabetes.The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. ''N Engl J Med'', 1993. 329(14): p. 977-86. As a consequence, in conjunction with insulin administrations, the prime requirement for diabetic p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Machine
A machine is a physical system using Power (physics), power to apply Force, forces and control Motion, movement to perform an action. The term is commonly applied to artificial devices, such as those employing engines or motors, but also to natural biological macromolecules, such as molecular machines. Machines can be driven by Animal power, animals and Human power, people, by natural forces such as Wind power, wind and Water power, water, and by Chemical energy, chemical, Thermal energy, thermal, or electricity, electrical power, and include a system of mechanism (engineering), mechanisms that shape the actuator input to achieve a specific application of output forces and movement. They can also include computers and sensors that monitor performance and plan movement, often called mechanical systems. Renaissance natural philosophers identified six simple machines which were the elementary devices that put a load into motion, and calculated the ratio of output force to input fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solvatochromism
In chemistry, solvatochromism is the phenomenon observed when the colour due to a solute is different when that solute is dissolved in different solvents. The solvatochromic effect is the way the spectrum of a substance (the solute) varies when the substance is dissolved in a variety of solvents. In this context, the dielectric constant and hydrogen bonding capacity are the most important properties of the solvent. With various solvents there is a different effect on the electronic ground state and excited state of the solute, so that the size of energy gap between them changes as the solvent changes. This is reflected in the absorption or emission spectrum of the solute as differences in the position, intensity, and shape of the spectroscopic bands. When the spectroscopic band occurs in the visible part of the spectrum solvatochromism is observed as a change of colour. This is illustrated by Reichardt's dye, as shown in the image. Negative solvatochromism corresponds to a hyp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyvinyl Alcohol
Poly(vinyl alcohol) (PVOH, PVA, or PVAl) is a water-soluble synthetic polymer. It has the idealized formula H2CH(OH)sub>''n''. It is used in papermaking, textile warp sizing, as a thickener and emulsion stabilizer in polyvinyl acetate (PVAc) adhesive formulations, in a variety of coatings, and 3D printing. It is colourless (white) and odorless. It is commonly supplied as beads or as solutions in water. Without an externally added crosslinking agent, PVA solution can be gelled through repeated freezing-thawing, yielding highly strong, ultrapure, biocompatible hydrogels which have been used for a variety of applications such as vascular stents, cartilages, contact lenses, etc. Uses PVA is used in a variety of medical applications because of its biocompatibility, low tendency for protein adhesion, and low toxicity. Specific uses include cartilage replacements, contact lenses, and eye drops. Polyvinyl alcohol is used as an aid in suspension polymerizations. Its largest applica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polyethylene Glycol
Polyethylene glycol (PEG; ) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH. Uses Medical uses * Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms. * PEG is the basis of a number of laxatives (as ''MiraLax''). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy. * PEG is used in medicines for treating disimpaction and maintenance therapy for children with constipation. * When attached to various protein medications or drug carriers, polyethylene glycol of suitable length slows down their clearance from the blood. * The possibility that PEG could be used to fuse axons is bei ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotinamide Adenine Dinucleotide Phosphate
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). It is used by all forms of cellular life. NADPH is the reduced form of NADP. NADP differs from NAD by the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety. This extra phosphate is added by NAD+ kinase and removed by NADP+ phosphatase. Biosynthesis NADP In general, NADP+ is synthesized before NADPH is. Such a reaction usually starts with NAD+ from either the de-novo or the salvage pathway, with NAD+ kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back to NADH to maintain a balance. Some forms of the NAD+ kina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IAEDANS
IAEDANS is an organic fluorophore (fluorescent molecule). It stands for 5-(amino)naphthalene-1-sulfonic acid. It is widely used as a marker in fluorescence spectroscopy. 1,5-IAEDANS has a peak excitation wavelength of 336 nm and a peak emission wavelength of 490 nm. The extinction coefficient of the dye is 5700. It is soluble in dimethylformamide (DMF) or buffer above pH 6 and reacts primarily with thiols. The absorption spectrum IAEDANS overlaps well with the emission spectrum of tryptophan, making it useful as an acceptor in FRET experiments. It can also be used as a resonance energy donor to fluorophores such as fluorescein Fluorescein is an organic compound and dye based on the xanthene tricyclic structural motif, formally belonging to triarylmethine dyes family. It is available as a dark orange/red powder slightly soluble in water and alcohol. It is widely used ..., Alexa Fluor 488, Oregon Green, and BODIPY FL. References Sulfonic acids Fluorescent dye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Badan
Badan may refer to: Arts and media Films * '' Do Badan'', a 1966 Hindi film directed by Raj Khosla * ''Jalte Badan'', a 1973 Bollywood drama * '' Kora Badan'', a 1974 Bollywood drama directed by B.S. Ghad * '' Kunwara Badan'', a 1973 Bollywood drama directed by Vimal Tiwari Other media * Badan Empire, a fictional organization in the TV special ''Birth of the 10th! Kamen Riders All Together!!'' and the manga ''Kamen Rider Spirits'' Organizations * Badan Informasi Geospasial, the national surveying and mapping agency of Indonesia * Badan Warisan Malaysia, an NGO formed in 1983, concerned with conservation of Malaysia's built heritage * Badan Standardisasi Nasional, the International Organization for Standardization (ISO) member body for Indonesia Other uses * Badan (ship), a type of dhow * Badan, a fluorescent probe molecule, analogue of Prodan * Badhan, Sanaag, a city and district in northeastern Somalia * Badan Chandra Borphukan, Indian military leader * ''Bergenia crassifo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Europium
Europium is a chemical element with the symbol Eu and atomic number 63. Europium is the most reactive lanthanide by far, having to be stored under an inert fluid to protect it from atmospheric oxygen or moisture. Europium is also the softest lanthanide, as it can be dented with a fingernail and easily cut with a knife. When oxidation is removed a shiny-white metal is visible. Europium was isolated in 1901 and is named after the continent of Europe. Being a typical member of the lanthanide series, europium usually assumes the oxidation state +3, but the oxidation state +2 is also common. All europium compounds with oxidation state +2 are slightly reducing. Europium has no significant biological role and is relatively non-toxic as compared to other heavy metals. Most applications of europium exploit the phosphorescence of europium compounds. Europium is one of the rarest of the rare-earth elements on Earth.Stwertka, Albert. ''A Guide to the Elements'', Oxford University Press, 1996, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tony James (chemist)
Tony D. James FRSC (born 7 October 1964) is a chemist who is currently Professor of Chemistry at the University of Bath and recipient of the Royal Society Wolfson Research Merit Award. He was educated at the University of East Anglia (BSc, 1986) and the University of Victoria (PhD, 1991). He was made a Fellow of the Royal Society of Chemistry in 2012 and received the Daiwa Adrian Prize This Daiwa Adrian Prize is an award given by The Daiwa Anglo-Japanese Foundation, a UK charity, to scientists who have made significant achievements in science through Anglo-Japanese collaborative research. Prizes are awarded every third year and ... in 2013. References 1964 births Living people Alumni of the University of East Anglia University of Victoria alumni Academics of the University of Bath Fellows of the Royal Society of Chemistry {{chemist-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boronic Acid
A boronic acid is an organic compound related to boric acid () in which one of the three hydroxyl groups () is replaced by an alkyl or aryl group (represented by R in the general formula ). As a compound containing a carbon–boron bond, members of this class thus belong to the larger class of organoboranes. Boronic acids act as Lewis acids. Their unique feature is that they are capable of forming reversible covalent complexes with sugars, amino acids, hydroxamic acids, etc. (molecules with vicinal, (1,2) or occasionally (1,3) substituted Lewis base donors (alcohol, amine, carboxylate)). The p''K''a of a boronic acid is ~9, but they can form tetrahedral boronate complexes with p''K''a ~7. They are occasionally used in the area of molecular recognition to bind to saccharides for fluorescent detection or selective transport of saccharides across membranes. Boronic acids are used extensively in organic chemistry as chemical building blocks and intermediates predominantly in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fluorescence Lifetime Imaging Microscopy
Fluorescence-lifetime imaging microscopy or FLIM is an imaging technique based on the differences in the exponential decay rate of the photon emission of a fluorophore from a sample. It can be used as an imaging technique in confocal microscopy, two-photon excitation microscopy, and multiphoton tomography. The fluorescence lifetime (FLT) of the fluorophore, rather than its intensity, is used to create the image in FLIM. Fluorescence lifetime depends on the local micro-environment of the fluorophore, thus precluding any erroneous measurements in fluorescence intensity due to change in brightness of the light source, background light intensity or limited photo-bleaching. This technique also has the advantage of minimizing the effect of photon scattering in thick layers of sample. Being dependent on the micro-environment, lifetime measurements have been used as an indicator for pH, viscosity and chemical species concentration. Fluorescence lifetimes A fluorophore which is excited b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aqueorin
Aequorin is a calcium-activated photoprotein isolated from the hydrozoan '' Aequorea victoria''. Its bioluminescence was studied decades before the protein was isolated from the animal by Osamu Shimomura in 1962. In the animal, the protein occurs together with the green fluorescent protein to produce green light by resonant energy transfer, while aequorin by itself generates blue light. Discussions of "jellyfish DNA" that can make "glowing" animals often refer to transgenic animals that express the green fluorescent protein, not aequorin, although both originally derive from the same animal. Apoaequorin, the protein portion of aequorin, is an ingredient in the dietary supplement Prevagen. The US Federal Trade Commission (FTC) has charged the maker with false advertising for its memory improvement claims. Discovery Work on aequorin began with E. Newton Harvey in 1921. Though Harvey was unable to demonstrate a classical luciferase-luciferin reaction, he showed that water ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
