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FMISO
18F-FMISO or fluoromisonidazole is a radiopharmaceutical used for PET imaging of hypoxia. It consists of a 2-nitroimidazole molecule labelled with the positron-emitter fluorine-18. Hypoxia is considered a negative prognostic marker for many solid tumours, and therefore an agent to detect and quantify it is highly desirable. FMISO was one of the first such agents, after initial synthesis in the late 1980s. It remains among the most popular agents for investigation of hypoxia imaging. Mechanism On entering a viable cell, the nitro group of the FMISO nitroimidazole is reduced. In non-hypoxic cells, the reduced FMISO molecule can be oxidised, and therefore diffuses out of the cell to circulate freely and ultimately be excreted. In hypoxic tumour cells however this oxidation cannot take place and the FMISO molecules accumulate. Their location can then be quantitatively imaged using positron emission tomography. Clinical use Large scale clinical trials with FMISO have not ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FMISO Hypoxia Accumulation Mechanism
18F-FMISO or fluoromisonidazole is a radiopharmaceutical used for Positron emission tomography, PET imaging of Hypoxia (medical), hypoxia. It consists of a 2-nitroimidazole molecule labelled with the positron-emitter fluorine-18. Hypoxia is considered a negative Prognosis marker, prognostic marker for many solid tumours, and therefore an agent to detect and quantify it is highly desirable. FMISO was one of the first such agents, after initial synthesis in the late 1980s. It remains among the most popular agents for investigation of hypoxia imaging. Mechanism On entering a viable cell, the Nitro compound, nitro group of the FMISO nitroimidazole is Reduction (chemistry), reduced. In non-hypoxic cells, the reduced FMISO molecule can be oxidised, and therefore diffuses out of the cell to circulate freely and ultimately be excreted. In tumour hypoxia, hypoxic tumour cells however this oxidation cannot take place and the FMISO molecules accumulate. Their location can then be Quantific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
