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Functional Ultrasound Imaging
Functional ultrasound imaging (fUS) is a medical ultrasound imaging technique of detecting or measuring changes in neural activities or metabolism, for example, the loci of brain activity, typically through measuring blood flow or hemodynamic changes. The method can be seen as an extension of Doppler imaging. Background Brain activation can either be directly measured by imaging electrical activity of neurons using voltage sensitive dyes, calcium imaging, electroencephalography, or magnetoencephalography, or indirectly by detecting hemodynamic changes in blood flow in the neurovascular systems through functional magnetic resonance imaging (fMRI), positron emission tomography (PET), Functional near-infrared spectroscopy (fNIRS), or Doppler ultrasonography )... Optical based methods generally provide the highest spatial and temporal resolutions; however, due to scattering, they are intrinsically limited to the investigation of the cortex. Thus, they are often used on animal m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Main Applications And Features Of Functional Ultrasound (fUS) Imaging
Main may refer to: Geography * Main River (other) **Most commonly the Main (river) in Germany *Main, Iran, a village in Fars Province *"Spanish Main", the Caribbean coasts of mainland Spanish territories in the 16th and 17th centuries *''The Main'', the diverse core running through Montreal, Quebec, Canada, also separating the Two Solitudes *Main (lunar crater), located near the north pole of the Moon *Main (Martian crater) People and organisations *Main (surname), a list of people with this family name *Ma'in, alternate spelling for the Minaeans, an ancient people of modern-day Yemen *Main (band), a British ambient band formed in 1991 *Chas. T. Main, an American engineering and hydroelectric company founded in 1893 *MAIN (Mountain Area Information Network), former operator of WPVM-LP (MAIN-FM) in Asheville, North Carolina, U.S. Ships * ''Main'' (ship), an iron sailing ship launched in 1884 * SS ''Main'', list of steamships with this name * ''Main'' (A515), a modern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Main Brain Functional Imaging Technique Resolutions
Main may refer to: Geography * Main River (other) **Most commonly the Main (river) in Germany *Main, Iran, a village in Fars Province *"Spanish Main", the Caribbean coasts of mainland Spanish territories in the 16th and 17th centuries *''The Main'', the diverse core running through Montreal, Quebec, Canada, also separating the Two Solitudes *Main (lunar crater), located near the north pole of the Moon *Main (Martian crater) People and organisations *Main (surname), a list of people with this family name *Ma'in, alternate spelling for the Minaeans, an ancient people of modern-day Yemen *Main (band), a British ambient band formed in 1991 *Chas. T. Main, an American engineering and hydroelectric company founded in 1893 *MAIN (Mountain Area Information Network), former operator of WPVM-LP (MAIN-FM) in Asheville, North Carolina, U.S. Ships * ''Main'' (ship), an iron sailing ship launched in 1884 * SS ''Main'', list of steamships with this name * ''Main'' (A515), a modern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electroencephalography Functional Magnetic Resonance Imaging
EEG-fMRI (short for ''EEG-correlated fMRI'' or ''electroencephalography-correlated functional magnetic resonance imaging'') is a multimodal neuroimaging technique whereby EEG and fMRI data are recorded synchronously for the study of electrical brain activity in correlation with haemodynamic changes in brain during the electrical activity, be it normal function or associated with disorders. Principle Scalp EEG reflects the brain's electrical activity, and in particular post- synaptic potentials (see Inhibitory postsynaptic current and Excitatory postsynaptic potential) in the cerebral cortex, whereas fMRI is capable of detecting haemodynamic changes throughout the brain through the BOLD effect. EEG-fMRI therefore allows measuring both neuronal and haemodynamic activity which comprise two important components of the neurovascular coupling mechanism. Methodology The simultaneous acquisition of EEG and fMRI data of sufficient quality requires solutions to problems linked to potentia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetoencephalography
Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain, using very sensitive magnetometers. Arrays of SQUIDs (superconducting quantum interference devices) are currently the most common magnetometer, while the SERF (spin exchange relaxation-free) magnetometer is being investigated for future machines. Applications of MEG include basic research into perceptual and cognitive brain processes, localizing regions affected by pathology before surgical removal, determining the function of various parts of the brain, and neurofeedback. This can be applied in a clinical setting to find locations of abnormalities as well as in an experimental setting to simply measure brain activity. History MEG signals were first measured by University of Illinois physicist David Cohen in 1968, before the availability of the SQUID, using a copper induction coil as the d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Magnetic Resonance Imaging
Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa in 1990. This is a type of specialized brain and body scan used to map neuron, neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not involve the use of injections, surgery, the ingestion of substances, or exposure to ionizing radiation. This measure is frequently corrupted by noise from various sources; hence, statistical procedures are used to extract the underlying si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in Metabolism, metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18F-FDG, -FDG is commonly used to detect cancer, Sodium fluoride#Medical imaging, NaF is widely used for detecting bone formation, and Isotopes of oxygen#Oxygen-15, oxygen-15 is sometimes used to measure blood flow. PET is a common medical imaging, imaging technique, a Scintigraphy#Process, medical scintillography technique used in nuclear medicine. A radiopharmaceutical, radiopharmaceutical — a radioisotope attached to a drug — is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Functional Near-infrared Spectroscopy
Functional near-infrared spectroscopy (fNIRS) is an optical brain monitoring technique which uses near-infrared spectroscopy for the purpose of functional neuroimaging. Using fNIRS, brain activity is measured by using near-infrared light to estimate cortical hemodynamic activity which occur in response to neural activity. Alongside EEG, fNIRS is one of the most common non-invasive neuroimaging techniques which can be used in portable contexts. The signal is often compared with the BOLD signal measured by fMRI and is capable of measuring changes both in oxy- and deoxyhemoglobin concentration, but can only measure from regions near the cortical surface. fNIRS may also be referred to as Optical Topography (OT) and is sometimes referred to simply as NIRS. Description fNIRS estimates the concentration of hemoglobin from changes in absorption of near infrared light. As light moves or propagates through the head, it is alternately scattered or absorbed by the tissue through which it tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doppler Ultrasonography
Doppler ultrasonography is medical ultrasonography that employs the Doppler effect to perform imaging of the movement of tissues and body fluids (usually blood), and their relative velocity to the probe. By calculating the frequency shift of a particular sample volume, for example, flow in an artery or a jet of blood flow over a heart valve, its speed and direction can be determined and visualized. Duplex ultrasonography sometimes refers to Doppler ultrasonography or spectral Doppler ultrasonography. Doppler ultrasonography consists of two components: brightness mode (B-mode) showing anatomy of the organs, and Doppler mode (showing blood flow) superimposed on the B-mode. Meanwhile, spectral Doppler ultrasonography consists of three components: B-mode, Doppler mode, and spectral waveform displayed at the lower half of the image. Therefore, "duplex ultrasonography" is a misnomer for spectral Doppler ultrasonography, and more exact name should be "triplex ultrasonography". This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ESPCI
ESPCI Paris (officially the École supérieure de physique et de chimie industrielles de la Ville de Paris; ''The City of Paris Industrial Physics and Chemistry Higher Educational Institution'') is a prestigious grande école founded in 1882 by the city of Paris, France. It educates undergraduate and graduate students in physics, chemistry and biology and conducts high-level research in those fields. It is ranked as the first French ''École d'Ingénieurs'' in the 2017 Shanghai Ranking. ESPCI Paris is a constituent college of Université PSL and a founding member of the ParisTech (Paris Institute of Technology) alliance. 5 researchers and alumni from ESPCI Paris have been awarded the Nobel Prize: * Pierre and Marie Curie (Physics, 1903), * Marie Curie - second Nobel Prize (Chemistry, 1911), * Frédéric Joliot-Curie (Chemistry, 1935), * Pierre-Gilles de Gennes (Physics, 1991), * Georges Charpak (Physics, 1992). Two thirds of the students enter the School following a competi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preclinical Applications Of FUS Imaging
In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals. The main goals of preclinical studies are to determine a starting, safe dose for first-in-human study and assess potential toxicity of the product, which typically include new medical devices, prescription drugs, and diagnostics. Companies use stylized statistics to illustrate the risks in preclinical research, such as that on average, only one in every 5,000 compounds that enters drug discovery to the stage of preclinical development becomes an approved drug. Types of preclinical research Each class of product may undergo different types of preclinical research. For instance, drugs may undergo pharmacodynamics (what the drug does to the body) (PD), pharmacokinetics (wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Neuroimaging Using Ultrasound
Clinical may refer to: Healthcare * Of or about a clinic, a healthcare facility * Of or about the practice of medicine Other uses * ''Clinical'' (film), a 2017 American horror thriller See also * * * Clinical chemistry, the analysis of bodily fluids for diagnostic and therapeutic purposes * Clinical death, the cessation of blood circulation and breathing * Clinical formulation, a theoretically-based explanation of information obtained from clinical assessment * Clinical governance, a systematic approach to maintaining and improving the quality of patient care * Clinical linguistics, linguistics applied to speech-language pathology * Clinical psychology, the understanding, preventing, and relieving psychologically-based distress or dysfunction * Clinical research, to determine the safety and effectiveness of medications etc. * Clinical significance, the practical importance of a treatment effect * Clinical trial, experiments or observations done in clinical research * Clinical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
