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Extracorporeal Photopheresis
__NOTOC__ In medicine, photopheresis (''aka'' extracorporeal photopheresis or ECP) is a form of apheresis and photodynamic therapy in which blood is subject to apheresis to separate buffy coat (White blood cell, WBC + platelets) from whole blood, chemically treated with 8-methoxypsoralen (instilled into a collection bag or given per os in advance), exposed to UVA radiation, ultraviolet light (UVA), and then returned to the patient. Activated 8-methoxypsoralen Crosslinking of DNA, crosslinks DNA in exposed cells, ultimately resulting apoptosis of Cell nucleus#Anucleated and multinucleated cells, nucleated cells. The photochemically damaged T-cells returned to the patient appear to induce cytotoxic effects on T-cell formation. The mechanism of such “antitumor” action has not been elucidated. A 1987 The New England Journal of Medicine, New England Journal of Medicine publication introduced photopheresis involving 8-methoxypsoralen., now standard Food and Drug Administration (Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicine
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
