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Ewens Sampling Formula
In population genetics, Ewens's sampling formula, describes the probabilities associated with counts of how many different alleles are observed a given number of times in the sample. Definition Ewens's sampling formula, introduced by Warren Ewens, states that under certain conditions (specified below), if a random sample of ''n'' gametes is taken from a population and classified according to the gene at a particular locus then the probability that there are ''a''1 alleles represented once in the sample, and ''a''2 alleles represented twice, and so on, is :\operatorname(a_1,\dots,a_n; \theta)=\prod_^n, for some positive number ''θ'' representing the population mutation rate, whenever a_1, \ldots, a_n is a sequence of nonnegative integers such that :a_1+2a_2+3a_3+\cdots+na_n=\sum_^ i a_i = n.\, The phrase "under certain conditions" used above is made precise by the following assumptions: * The sample size ''n'' is small by comparison to the size of the whole population; and * T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Population Genetics
Population genetics is a subfield of genetics that deals with genetic differences within and between populations, and is a part of evolutionary biology. Studies in this branch of biology examine such phenomena as adaptation, speciation, and population structure. Population genetics was a vital ingredient in the emergence of the modern evolutionary synthesis. Its primary founders were Sewall Wright, J. B. S. Haldane and Ronald Fisher, who also laid the foundations for the related discipline of quantitative genetics. Traditionally a highly mathematical discipline, modern population genetics encompasses theoretical, laboratory, and field work. Population genetic models are used both for statistical inference from DNA sequence data and for proof/disproof of concept. What sets population genetics apart from newer, more phenotypic approaches to modelling evolution, such as evolutionary game theory and adaptive dynamics, is its emphasis on such genetic phenomena as dominance, epi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Probability Distribution
In probability theory and statistics, a probability distribution is the mathematical function that gives the probabilities of occurrence of different possible outcomes for an experiment. It is a mathematical description of a random phenomenon in terms of its sample space and the probabilities of events (subsets of the sample space). For instance, if is used to denote the outcome of a coin toss ("the experiment"), then the probability distribution of would take the value 0.5 (1 in 2 or 1/2) for , and 0.5 for (assuming that the coin is fair). Examples of random phenomena include the weather conditions at some future date, the height of a randomly selected person, the fraction of male students in a school, the results of a survey to be conducted, etc. Introduction A probability distribution is a mathematical description of the probabilities of events, subsets of the sample space. The sample space, often denoted by \Omega, is the set of all possible outcomes of a random phe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theory Of Probability Distributions
A theory is a rational type of abstract thinking about a phenomenon, or the results of such thinking. The process of contemplative and rational thinking is often associated with such processes as observational study or research. Theories may be scientific, belong to a non-scientific discipline, or no discipline at all. Depending on the context, a theory's assertions might, for example, include generalized explanations of how nature works. The word has its roots in ancient Greek, but in modern use it has taken on several related meanings. In modern science, the term "theory" refers to scientific theories, a well-confirmed type of explanation of nature, made in a way consistent with the scientific method, and fulfilling the criteria required by modern science. Such theories are described in such a way that scientific tests should be able to provide empirical support for it, or empirical contradiction ("falsify") of it. Scientific theories are the most reliable, rigorous, and compre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomathematics
Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to prove and validate the scientific theories. The field is sometimes called mathematical biology or biomathematics to stress the mathematical side, or theoretical biology to stress the biological side. Theoretical biology focuses more on the development of theoretical principles for biology while mathematical biology focuses on the use of mathematical tools to study biological systems, even though the two terms are sometimes interchanged. Mathematical biology aims at the mathematical representation and modeling of biological processes, using techniques and tools of applied mathematics. It can be useful in both theoretical and prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unified Neutral Theory Of Biodiversity
The unified neutral theory of biodiversity and biogeography (here "Unified Theory" or "UNTB") is a theory and the title of a monograph by ecologist Stephen P. Hubbell. It aims to explain the diversity and relative abundance of species in ecological communities. Like other neutral theories of ecology, Hubbell assumes that the differences between members of an ecological community of trophically similar species are "neutral", or irrelevant to their success. This implies that niche differences do not influence abundance and the abundance of each species follows a random walk. The theory has sparked controversy, and some authors consider it a more complex version of other null models that fit the data better. "Neutrality" means that at a given trophic level in a food web, species are equivalent in birth rates, death rates, dispersal rates and speciation rates, when measured on a per-capita basis. This can be considered a null hypothesis to niche theory. Hubbell built on earlier ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coalescent Theory
Coalescent theory is a model of how alleles sampled from a population may have originated from a common ancestor. In the simplest case, coalescent theory assumes no recombination, no natural selection, and no gene flow or population structure, meaning that each variant is equally likely to have been passed from one generation to the next. The model looks backward in time, merging alleles into a single ancestral copy according to a random process in coalescence events. Under this model, the expected time between successive coalescence events increases almost exponentially back in time (with wide variance). Variance in the model comes from both the random passing of alleles from one generation to the next, and the random occurrence of mutations in these alleles. The mathematical theory of the coalescent was developed independently by several groups in the early 1980s as a natural extension of classical population genetics theory and models, but can be primarily attributed to John K ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Restaurant Table Distribution
In probability theory, the Chinese restaurant process is a discrete-time stochastic process, analogous to seating customers at tables in a restaurant. Imagine a restaurant with an infinite number of circular tables, each with infinite capacity. Customer 1 sits at the first table. The next customer either sits at the same table as customer 1, or the next table. This continues, with each customer choosing to either sit at an occupied table with a probability proportional to the number of customers already there (i.e., they are more likely to sit at a table with many customers than few), or an unoccupied table. At time ''n'', the ''n'' customers have been partitioned among ''m'' ≤ ''n'' tables (or blocks of the partition). The results of this process are exchangeable, meaning the order in which the customers sit does not affect the probability of the final distribution. This property greatly simplifies a number of problems in population genetics, linguistic analysis, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Restaurant Process
In probability theory, the Chinese restaurant process is a discrete-time stochastic process, analogous to seating customers at tables in a restaurant. Imagine a restaurant with an infinite number of circular tables, each with infinite capacity. Customer 1 sits at the first table. The next customer either sits at the same table as customer 1, or the next table. This continues, with each customer choosing to either sit at an occupied table with a probability proportional to the number of customers already there (i.e., they are more likely to sit at a table with many customers than few), or an unoccupied table. At time ''n'', the ''n'' customers have been partitioned among ''m'' ≤ ''n'' tables (or blocks of the partition). The results of this process are exchangeable, meaning the order in which the customers sit does not affect the probability of the final distribution. This property greatly simplifies a number of problems in population genetics, linguistic analysis, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Random Permutation
A random permutation is a random ordering of a set of objects, that is, a permutation-valued random variable. The use of random permutations is often fundamental to fields that use randomized algorithms such as coding theory, cryptography, and simulation. A good example of a random permutation is the shuffling of a deck of cards: this is ideally a random permutation of the 52 cards. Generating random permutations Entry-by-entry brute force method One method of generating a random permutation of a set of length ''n'' uniformly at random (i.e., each of the ''n''! permutations is equally likely to appear) is to generate a sequence by taking a random number between 1 and ''n'' sequentially, ensuring that there is no repetition, and interpreting this sequence (''x''1, ..., ''x''''n'') as the permutation : \begin 1 & 2 & 3 & \cdots & n \\ x_1 & x_2 & x_3 & \cdots & x_n \\ \end, shown here in two-line notation. This brute-force method will require occasional retries whenever the ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integer Partition
In number theory and combinatorics, a partition of a positive integer , also called an integer partition, is a way of writing as a sum of positive integers. Two sums that differ only in the order of their summands are considered the same partition. (If order matters, the sum becomes a composition.) For example, can be partitioned in five distinct ways: : : : : : The order-dependent composition is the same partition as , and the two distinct compositions and represent the same partition as . A summand in a partition is also called a part. The number of partitions of is given by the partition function . So . The notation means that is a partition of . Partitions can be graphically visualized with Young diagrams or Ferrers diagrams. They occur in a number of branches of mathematics and physics, including the study of symmetric polynomials and of the symmetric group and in group representation theory in general. Examples The seven partitions of 5 are: * 5 * 4 + 1 * 3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetic Drift
Genetic drift, also known as allelic drift or the Wright effect, is the change in the frequency of an existing gene variant (allele) in a population due to random chance. Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation. It can also cause initially rare alleles to become much more frequent and even fixed. When few copies of an allele exist, the effect of genetic drift is more notable, and when many copies exist, the effect is less notable. In the middle of the 20th century, vigorous debates occurred over the relative importance of natural selection versus neutral processes, including genetic drift. Ronald Fisher, who explained natural selection using Mendelian genetics, held the view that genetic drift plays at most a minor role in evolution, and this remained the dominant view for several decades. In 1968, population geneticist Motoo Kimura rekindled the debate with his neutral theory of molecular evolution, which claims that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Probabilities
Probability is the branch of mathematics concerning numerical descriptions of how likely an event is to occur, or how likely it is that a proposition is true. The probability of an event is a number between 0 and 1, where, roughly speaking, 0 indicates impossibility of the event and 1 indicates certainty."Kendall's Advanced Theory of Statistics, Volume 1: Distribution Theory", Alan Stuart and Keith Ord, 6th Ed, (2009), .William Feller, ''An Introduction to Probability Theory and Its Applications'', (Vol 1), 3rd Ed, (1968), Wiley, . The higher the probability of an event, the more likely it is that the event will occur. A simple example is the tossing of a fair (unbiased) coin. Since the coin is fair, the two outcomes ("heads" and "tails") are both equally probable; the probability of "heads" equals the probability of "tails"; and since no other outcomes are possible, the probability of either "heads" or "tails" is 1/2 (which could also be written as 0.5 or 50%). These conce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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