|
Ethel Bidwell
Ethel Bidwell (1919–2003) was a British research scientist who investigated blood coagulation. In 1950, Bidwell, an enzyme chemist, joined the Oxford University team headed by Gwyn Macfarlane. Two years later, she began to study plasma concentration and selective extraction of factor VIII. By 1953 she had devised a technique to extract and concentrate bovine factor VIII that was 8000 times stronger than human plasma. In 1959 she was working on the preparation of human coagulation factors at the Medical Research Council Blood Coagulation Research Unit at Churchill Hospital, Headington, Oxford. Tilli Tansey wrote of inviting Bidwell to a witness seminar convened by the History of Modern Biomedicine Research Group The History of Modern Biomedicine Research Group (HoMBRG) is an academic organisation specialising in recording and publishing the oral history of twentieth and twenty-first century biomedicine. It was established in 1990 as the Wellcome Trust's H ...: Furth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Scientist
A scientist is a person who conducts scientific research to advance knowledge in an area of the natural sciences. In classical antiquity, there was no real ancient analog of a modern scientist. Instead, philosophers engaged in the philosophical study of nature called natural philosophy, a precursor of natural science. Though Thales (circa 624-545 BC) was arguably the first scientist for describing how cosmic events may be seen as natural, not necessarily caused by gods,Frank N. Magill''The Ancient World: Dictionary of World Biography'', Volume 1 Routledge, 2003 it was not until the 19th century that the term ''scientist'' came into regular use after it was coined by the theologian, philosopher, and historian of science William Whewell in 1833. In modern times, many scientists have advanced degrees in an area of science and pursue careers in various sectors of the economy such as academia, industry, government, and nonprofit environments.'''' History The roles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Coagulation
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation begins almost instantly after an injury to the endothelium lining a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial tissue factor to plasma factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called ''primary hemostasis. Secondary hemostasis'' occurs simultaneously: additional coagulation (clotting) factors beyond factor VII ( listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug. Disorders of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University
Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the University of Oxford, the oldest university in the English-speaking world; it has buildings in every style of English architecture since late Anglo-Saxon. Oxford's industries include motor manufacturing, education, publishing, information technology and science. History The history of Oxford in England dates back to its original settlement in the Saxon period. Originally of strategic significance due to its controlling location on the upper reaches of the River Thames at its junction with the River Cherwell, the town grew in national importance during the early Norman period, and in the late 12th century became home to the fledgling University of Oxford. The city was besieged during The Anarchy in 1142. The university rose to domina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Gwyn Macfarlane
Robert Gwyn Macfarlane (26 June 1907 – 26 March 1987) was an English hematologist. Life Born in Worthing, Sussex, Gwyn Macfarlane left Cheltenham College in 1924 and a year later entered the Medical School of St Bartholomew's Hospital, London. In 1936 he married Hilary Carson MD and over the next 11 years had five children, a girl followed by four boys. Hilary practised as a GP, whilst always offering Gwyn great academic support. She died in 2010 aged 100 years. During Macfarlane's clinical years he was exposed to the sufferings of haemophiliacs and this subject became the core for his lifelong study into the processes of blood clotting. He examined the venom of many different snakes and isolated the poison of the Russell's viper to have the strongest blood coagulant powerssee video He found that when a compound that included venom at dilutions of 1 in 100,000 was applied to a wound, bleeding diminished. This medicine was later marketed as ''Stypven'' by Burroughs Wel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Factor VIII
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII is encoded by the ''F8'' gene. Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. This protein circulates in the bloodstream in an inactive form, bound to another molecule called von Willebrand factor, until an injury that damages blood vessels occurs. In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. This interaction sets off a chain of additional chemical reactions that form a blood clot. Factor VIII participates in blood coagulation; it is a cofactor for factor IXa, which, in the presence of Ca2+ and phospholipids, forms a complex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Council (United Kingdom)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tilli Tansey
Elizabeth Matilda Tansey (known as Tilli) is an Emerita Professor of the history of medicine and former neurochemist, best known for her role in the Wellcome Trust's witness seminars. She previously worked at Queen Mary University of London (QMUL). Education Tansley was educated at the University of Sheffield where she was awarded a PhD in 1978 for histochemical studies of the brain in cephalopods. After switching fields from neuroscience to the history of science, she was awarded a second PhD in the history of science for her research on the early career of the nobel laureate Henry Hallett Dale. Career and research Between 2012 and 2017, she was head of the History of Modern Biomedicine Research Group, on a five-year research project funded by the Wellcome Trust titled ''The Makers of Modern Biomedicine: Testimonies and Legacy'', to record oral testimonies from those who have contributed significantly to modern medical sciences. Tansey's Witness Seminar series, held at th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Witness Seminar
A witness seminar is a method of collecting oral history material, whereby a number of people connected to an event or topic meet to share recollections of their involvement. The results may be recorded or videoed and an edited transcript published. The concept was conceived and formalised by the Institute of Contemporary British History (now the Centre for Contemporary British History The Institute of Historical Research (IHR) is a British educational organisation providing resources and training for historical researchers. It is part of the School of Advanced Study in the University of London and is located at Senate Hous ...) and was subsequently adopted by The History of Modern Biomedicine Group, and published as volumes in the ''Wellcome Witnesses to Contemporary Medicine'' series. References {{Reflist External links Catalogue of the Centre for Contemporary British History Witness Seminar Programme, 1986- Oral history ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
History Of Modern Biomedicine Research Group
The History of Modern Biomedicine Research Group (HoMBRG) is an academic organisation specialising in recording and publishing the oral history of twentieth and twenty-first century biomedicine. It was established in 1990 as the Wellcome Trust's History of Twentieth Century Medicine Group, and reconstituted in October 2010 as part of the School of History at Queen Mary University of London. History The project originated as The Wellcome Trust's History of Twentieth Century Medicine Group, and later functioned as the Academic Unit of the Wellcome Institute for the History of Medicine. It was originally established at the Royal College of Physicians in 1990 and comprised Sir Christopher Booth (the Harveian Librarian) and Professor Tilli Tansey. Its purpose was to devise ways of stimulating historians, scientists & clinicians to discuss, preserve and write the history of recent biomedicine. The Group's activities were originally overseen by a Programme Committee, which included pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1919 Births
Events January * January 1 ** The Czechoslovak Legions occupy much of the self-proclaimed "free city" of Pressburg (now Bratislava), enforcing its incorporation into the new republic of Czechoslovakia. ** HMY ''Iolaire'' sinks off the coast of the Hebrides; 201 people, mostly servicemen returning home to Lewis and Harris, are killed. * January 2– 22 – Russian Civil War: The Red Army's Caspian-Caucasian Front begins the Northern Caucasus Operation against the White Army, but fails to make progress. * January 3 – The Faisal–Weizmann Agreement is signed by Emir Faisal (representing the Arab Kingdom of Hejaz) and Zionist leader Chaim Weizmann, for Arab–Jewish cooperation in the development of a Jewish homeland in Palestine, and an Arab nation in a large part of the Middle East. * January 5 – In Germany: ** Spartacist uprising in Berlin: The Marxist Spartacus League, with the newly formed Communist Party of Germany and the Independent Social De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Place Of Birth Missing
Place may refer to: Geography * Place (United States Census Bureau), defined as any concentration of population ** Census-designated place, a populated area lacking its own municipal government * "Place", a type of street or road name ** Often implies a dead end (street) or cul-de-sac * Place, based on the Cornish word "plas" meaning mansion * Place, a populated place, an area of human settlement ** Incorporated place (see municipal corporation), a populated area with its own municipal government * Location (geography), an area with definite or indefinite boundaries or a portion of space which has a name in an area Placenames * Placé, a commune in Pays de la Loire, Paris, France * Plače, a small settlement in Slovenia * Place (Mysia), a town of ancient Mysia, Anatolia, now in Turkey * Place, New Hampshire, a location in the United States * Place House, a 16th-century mansion largely remodelled in the 19th century, in Fowey, Cornwall * Place House, a 19th-century mansion on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2003 Deaths
3 (three) is a number, numeral and digit. It is the natural number following 2 and preceding 4, and is the smallest odd prime number and the only prime preceding a square number. It has religious or cultural significance in many societies. Evolution of the Arabic digit The use of three lines to denote the number 3 occurred in many writing systems, including some (like Roman and Chinese numerals) that are still in use. That was also the original representation of 3 in the Brahmic (Indian) numerical notation, its earliest forms aligned vertically. However, during the Gupta Empire the sign was modified by the addition of a curve on each line. The Nāgarī script rotated the lines clockwise, so they appeared horizontally, and ended each line with a short downward stroke on the right. In cursive script, the three strokes were eventually connected to form a glyph resembling a with an additional stroke at the bottom: ३. The Indian digits spread to the Caliphate in the 9th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
