Esther Killick
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Esther Killick
Esther Margaret Killick (3 May 1902 – 31 May 1960) was an English physiologist who was a professor of physiology at the London School of Medicine for Women (Royal Free Hospital School of Medicine) from 1941 until her death in 1960. Her main research interests lay in respiratory physiology and carbon monoxide poisoning. Early life and education Killick was born on 3 May 1902 in Ilford to Arthur Killick and Henrietta Fanny (née Moulton). She attended Leeds Girls' High School and went on to study at the University of Leeds, earning a BSc with honours in physiology followed by an MB ChB in 1929. She later received an MSc (1937) and DSc (1952) from Leeds. Career Killick worked in the physiology department of the University of Leeds from 1929 to 1931, as an investigator to the Safety in Mines Research Board. During this period she studied carbon monoxide poisoning and acclimatisation, and collaborated with John Scott Haldane from the University of Birmingham. In 1935, she was ap ...
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Industrial Medicine
Occupational medicine, until 1960 called industrial medicine, is the branch of medicine which is concerned with the maintenance of health in the workplace, including prevention and treatment of diseases and injuries, with secondary objectives of maintaining and increasing productivity and social adjustment in the workplace. Therefore, the branch of clinical medicine active in the field of occupational health and safety. OM specialists work to ensure that the highest standards of occupational health and safety are achieved and maintained in the workplace. While OM may involve a wide number of disciplines, it centers on preventive medicine and the management of illness, injury, and disability related to the workplace. Occupational physicians must have a broad knowledge of clinical medicine and be competent in some important fields. They often advise international bodies, governmental and state agencies, organizations, and trade unions. There are contextual links to physical medi ...
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Heme Oxygenase
Heme oxygenase, or haem oxygenase, (HMOX, commonly abbreviated as HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin, ferrous ion, and carbon monoxide. There are many heme degrading enzymes in nature. In general, only aerobic heme degrading enzymes are referred to as HMOX-like enzymes whereas anaerobic enzymes are typically not affiliated with the HMOX family. Heme oxygenase Heme oxygenase (alternatively spelled using haem or oxidase) catalyzes the degradation of heme to biliverdin/bilirubin, ferrous ion, and carbon monoxide. The human genome may encode three isoforms of HMOX. The degradation of heme forms three distinct chromogens as seen in healing cycle of a bruise. This reaction can occur in virtually every cell and platelet; the classic example is the healing process of a contusion, which forms different chromogens as it gradually heals: (red) heme to (green) biliverdin to (yellow) bilirubin which is widely known for jaundice. In general, aside ...
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Carbon Monoxide-releasing Molecules
Carbon monoxide-releasing molecules (CORMs) are chemical compounds designed to release controlled amounts of carbon monoxide (CO). CORMs are being developed as potential therapeutic agents to locally deliver CO to cells and tissues, thus overcoming limitations of CO gas inhalation protocols. CO is best known for its toxicity in carbon monoxide poisoning at high doses. However, CO is a gasotransmitter and supplemental low dosage of CO has been linked to therapeutic benefits. Pre-clinical research has focused on CO's anti-inflammatory activity with significant applications in cardiovascular disease, oncology, transplant surgery, and neuroprotection. History The simplest source of CO is from a combustion reaction via burning sources such as fossil fuels or fire wood. Sources releasing CO upon thermal decomposition or combustion are generally not considered CORMs. Therapeutic interest in CO dates back to the study of factitious airs (hydrocarbonate) in the 1790s by Thomas Beddoes ...
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Respiratory Epithelium
Respiratory epithelium, or airway epithelium, is a type of ciliated columnar epithelium found lining most of the respiratory tract as respiratory mucosa, where it serves to moisten and protect the airways. It is not present in the vocal cords of the larynx, or the oropharynx and laryngopharynx, where instead the epithelium is stratified squamous. It also functions as a barrier to potential pathogens and foreign particles, preventing infection and tissue injury by the secretion of mucus and the action of mucociliary clearance. Structure The respiratory epithelium lining the upper respiratory airways is classified as ciliated pseudostratified columnar epithelium. This designation is due to the arrangement of the multiple cell types composing the respiratory epithelium. While all cells make contact with the basement membrane and are, therefore, a single layer of cells, their nuclei are not aligned in the same plane. Hence, it appears as though several layers of cells are presen ...
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Hypoxia (medical)
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either '' generalized'', affecting the whole body, or ''local'', affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise.. Hypoxia differs from hypoxemia and anoxemia, in that hypoxia refers to a state in which oxygen present in a tissue or the whole body is insufficient, whereas hypoxemia and anoxemia refer specifically to states that have low or no oxygen in the blood. Hypoxia in which there is complete absence of oxygen supply is referred to as anoxia. Hypoxia can be due to external causes, when the breathing gas is hypoxic, or internal causes, such as reduced effectiveness of gas transfer in the lungs, reduced capacity of the blood to carry oxygen, compromised general ...
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Birmingham Gazette
The ''Birmingham Gazette'', known for much of its existence as ''Aris's Birmingham Gazette'', was a newspaper that was published and circulated in Birmingham, England, from the eighteenth to the twentieth centuries. Founded as a weekly publication in 1741, it moved to daily production in 1862, and was absorbed by the ''Birmingham Post'' in 1956. The newspaper's title was initially ''Birmingham Gazette and General Correspondent'' from 1741; ''Aris's Birmingham Gazette'' by 1743, and continuing until 1862; ''Birmingham Daily Gazette'' from 1862 to 1904; ''Birmingham Gazette & Express'' from 1904 to 1912; and ''Birmingham Gazette'' from 1912 to 1956. In November 1956 the ''Birmingham Gazette'' was absorbed by the ''Birmingham Post''. The merger led to the publication of ''The Birmingham Post & Birmingham Gazette'' which ran until 1964. History The ''Gazette'' was founded as the ''Birmingham Gazette and General Correspondent'' by Thomas Aris, a stationer from London who had moved ...
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University Of The West Indies
The University of the West Indies (UWI), originally University College of the West Indies, is a public university system established to serve the higher education needs of the residents of 17 English-speaking countries and territories in the Caribbean: Anguilla, Antigua and Barbuda, The Bahamas, Barbados, Belize, Bermuda, British Virgin Islands, Cayman Islands, Dominica, Grenada, Guyana, Jamaica, Montserrat, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Trinidad and Tobago, and Turks and Caicos Islands. Each country is either a member of the Commonwealth of Nations or a British Overseas Territory. The aim of the university is to help "unlock the potential for economic and cultural growth" in the West Indies, thus allowing improved regional autonomy. The university was originally instituted as an independent external college of the University of London. The university has produced students who have excelled in a number of disciplines such as the arts ...
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University Of Ibadan
The University of Ibadan (UI) is a public research university in Ibadan, Nigeria. The university was founded in 1948 as University College Ibadan, one of many colleges within the University of London. It became an independent university in 1962 and is the oldest degree-awarding institution in Nigeria. Through its graduate network, the University of Ibadan has contributed to the political, industrial, economic and cultural development of Nigeria. The history and influence of the University of Ibadan have made it one of the most prestigious universities in Africa. The University of Ibadan is made up of 92 academic departments organized into 17 faculties, namely Arts, Science, Basic Medical Sciences, Clinical Sciences, Agriculture, the Social Sciences, Education, Veterinary Medicine, Pharmacy, Technology, Law, Public Health, Dentistry, Economics and Management Sciences, Renewable Natural Resources, Environmental Design and Management, and Multidisciplinary Studies. The Faculties ...
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University Of London
The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degree-awarding examination board for students holding certificates from University College London and King's College London and "other such other Institutions, corporate or unincorporated, as shall be established for the purpose of Education, whether within the Metropolis or elsewhere within our United Kingdom". This fact allows it to be one of three institutions to claim the title of the third-oldest university in England, and moved to a federal structure in 1900. It is now incorporated by its fourth (1863) royal charter and governed by the University of London Act 2018. It was the first university in the United Kingdom to introduce examinations for women in 1869 and, a decade later, the first to admit women to degrees. In 1913, it appointe ...
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Physiological Society
The Physiological Society, founded in 1876, is a learned society for physiologists in the United Kingdom. History The Physiological Society was founded in 1876 as a dining society "for mutual benefit and protection" by a group of 19 physiologists, led by John Burdon Sanderson and Michael Foster, as a result of the 1875 Royal Commission on Vivisection and the subsequent 1876 Cruelty to Animals Act. Other founding members included: William Sharpey, Thomas Huxley, George Henry Lewes, Francis Galton, John Marshall, George Murray Humphry, Frederick William Pavy, Lauder Brunton, David Ferrier, Philip Pye-Smith, Walter H. Gaskell, John Gray McKendrick, Emanuel Edward Klein, Edward Schafer, Francis Darwin, George Romanes, and Gerald Yeo. The aim was to promote the advancement of physiology. Charles Darwin and William Sharpey were elected as the society's first two Honorary Members. The society first met at Sanderson's London home. The first rules of the society offered membershi ...
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European Coal And Steel Community
The European Coal and Steel Community (ECSC) was a European organization created after World War II to regulate the coal and steel industries. It was formally established in 1951 by the Treaty of Paris, signed by Belgium, France, Italy, Luxembourg, the Netherlands, and West Germany. The ECSC was an international organization based on the principle of supranationalism, and started a process of integration which ultimately led to the creation of the European Union. The ECSC was first proposed as the Schuman Declaration by French foreign minister Robert Schuman on the 9th of May 1950 (today's Europe Day of the EU), the day after the fifth anniversary of the end of World War II, as a way to prevent further war between France and Germany. He declared he aimed to "make war not only unthinkable but materially impossible" which was to be achieved by regional integration, of which the ECSC was the first step. The Treaty would create a common market for coal and steel among its membe ...
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