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Encaprin
Encaprin was a brand of safety-coated aspirin capsules made by Procter & Gamble in the mid-1980s through its Norwich Eaton Pharmaceuticals division. In 1986, the brand was involved in a cyanide poisoning hoax, and its sales never recovered. History Procter & Gamble submitted a patent application on 14 March 1983 for its new line of over-the-counter micro-granulated aspirin capsules, to be sold under the name Encaprin, chosen for its phonetic similarity to the word aspirin. The product was first released in January 1984 to a lead market in Tucson, Arizona, and saw its national release in early May. A national television advertising campaign began on July 15, 1984, where it was marketed as a fast-acting analgesic, particularly for mild arthritis relief, while being easier on the stomach than traditional or buffered aspirin tablets, due to its distributed aspirin micro-granules. The brand saw problems early on when a trademark infringement suit was filed by SmithKline Beckman, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chicago Tylenol Murders
The Chicago Tylenol murders were a series of poisoning deaths resulting from drug tampering in the Chicago metropolitan area in 1982. The victims had all taken Tylenol-branded acetaminophen capsules that had been laced with potassium cyanide. Seven people died in the original poisonings, with several more deaths in subsequent copycat crimes. No suspect has been charged or convicted of the poisonings. New York City resident James William Lewis was convicted of extortion for sending a letter to Tylenol's manufacturer, Johnson & Johnson, that took responsibility for the deaths and demanded $1 million to stop them, but evidence tying Lewis to the actual poisoning never emerged. The incidents led to reforms in the packaging of over-the-counter drugs and to federal anti-tampering laws. Incidents On September 29, 1982, Mary Kellerman (12) of Elk Grove Village, Illinois, died after taking a capsule of Extra-Strength Tylenol. Adam Janus (27) of Arlington Heights, died in the hospital ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tylenol (brand)
Tylenol () is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol (known in the United States, Canada, and various other countries as ''acetaminophen''), an analgesic and antipyretic. Like the words ''paracetamol'' and ''acetaminophen'', the brand name ''Tylenol'' is derived from a chemical name for the compound, ''N''-acetyl-''para''-aminophenol (APAP). The brand name is owned by McNeil Consumer Healthcare, a subsidiary of Johnson & Johnson. Medical uses The active ingredient in Tylenol is paracetamol, a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). Formulations with additional active ingredients intended to target specific applications are sold under the Tylenol brand. These can include codeine as co-codamol, dextromethorphan, methocarbamol, guaifenesin, pseudoephedrine, c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Customer Support
Customer support is a range of services to assist customers in making cost effective and correct use of a product. It includes assistance in planning, installation, training, troubleshooting, maintenance, upgrading, and disposal of a product. Regarding technology products such as mobile phones, televisions, computers, software products or other electronic or mechanical goods, it is termed technical support. Phone and Emails are the primary means to offer web-based assistance for your customers when matters do not require an immediate answer. Low-cost, non-intrusive and anywhere-anytime access are some of the advantages of email-based communications. Trouble Ticketing System and CRM Applications help keep track of a series of follow-up correspondence with a particular customer. Services offered via email response management is claims processing, polling/media analysis, subscription services, troubleshooting, complaint registrations etc. Being a successful Customer Support agent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toll-free Telephone Numbers In The North American Numbering Plan
In the United States of America, Canada, and other countries participating in the North American Numbering Plan, a toll-free telephone number has one of the area codes 800, 833, 844, 855, 866, 877, and 888. Area code 822 is expected to be used in the future, followed by 880 through 887, then 889. However, 811 is reserved as a three-digit number for various other purposes. In addition, 899 is reserved as a member of the series ''x9x'' for future numbering plan expansion. Calls to these numbers are free to the caller if dialed from land-line phones, but may incur mobile airtime charges for cellular phones. History Most of the United States and all of Canada uses a flat-rate structure for local calls, which incur no per-call cost to residential subscribers. Long distance calls had higher prices. As regulators in North America had long allowed long-distance calling to be priced artificially high in return for artificially low rates for local service, subscribers tended to make toll ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tampering (crime)
Tampering can refer to many forms of sabotage but the term is often used to mean intentional modification of products in a way that would make them harmful to the consumer. This threat has prompted manufacturers to make products that are either difficult to modify or at least difficult to modify without warning the consumer that the product has been tampered with. Since the person making the modification is typically long gone by the time the crime is discovered, many of these cases are never solved. The crime is often linked with attempts to extort money from the manufacturer, and in many cases no contamination to a product ever takes place. Fraud is sometimes handled as a matter of civil law, but actual modification of products is almost always a matter of criminal law. Examples 1982 Chicago Tylenol murders Seven people died in this incident in the United States after taking medication that had been contaminated with cyanide. One man was later convicted of extortion, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayer
Bayer AG (, commonly pronounced ; ) is a German multinational corporation, multinational pharmaceutical and biotechnology company and one of the largest pharmaceutical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include pharmaceuticals; consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the Euro Stoxx 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer and dyer Friedrich Weskott. As was common in this era, the company was established as a dyestuffs producer. The versatility of aniline chemistry led Bayer to expand their business into other areas, and in 1899 Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. In 1904 Bayer received a trademark for the "Bayer Cross" logo, which was subsequently stamped onto each aspirin tablet, creating an iconic product that is still sold by Bayer. Ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sterling Drug
Sterling Drug was an American global pharmaceutical company, also known as Sterling Winthrop, Inc. in its last years (after the merger with Winthrop-Stearns Inc. which itself resulted from the merger of ''Winthrop Chemical Company Inc.'' and ''Frederick Stearns & Company''). It was formerly known as ''Sterling Winthrop Pharmaceuticals'', whose primary product lines included diagnostic imaging agents, hormonal products, cardiovascular products, analgesics, antihistamines and muscle relaxants. Chemical compounds produced by this company were often known by their manufacturing code which consisted of the abbreviation WIN (for Winthrop) followed by a number. For example, WIN 18,320 was nalidixic acid, the first quinolone antibiotic. History 1910s The Company was established in 1901 (then called ''Neuralgyline Co.'') in Wheeling, West Virginia, by Albert H. Diebold and William E. Weiss, a pharmacist. At the end of World War I in 1918, Sterling purchased the US assets of a German ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intrinsic Activity
Intrinsic activity (IA) and efficacy refer to the relative ability of a drug-receptor complex to produce a maximum functional response. This must be distinguished from the affinity, which is a measure of the ability of the drug to bind to its molecular target, and the EC50, which is a measure of the potency of the drug and which is proportional to both efficacy and affinity. This use of the word "efficacy" was introduced by Stephenson (1956) to describe the way in which agonists vary in the response they produce, even when they occupy the same number of receptors. High efficacy agonists can produce the maximal response of the receptor system while occupying a relatively low proportion of the receptors in that system. There is a distinction between efficacy and intrinsic activity. Mechanism of efficacy Agonists of lower efficacy are not as efficient at producing a response from the drug-bound receptor, by stabilizing the active form of the drug-bound receptor. Therefore, they ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Markup (business)
Markup (or price spread) is the difference between the selling price of a good or service and cost. It is often expressed as a percentage over the cost. A markup is added into the total cost incurred by the producer of a good or service in order to cover the costs of doing business and create a profit. The total cost reflects the total amount of both fixed and variable expenses to produce and distribute a product. Markup can be expressed as a fixed amount or as a percentage of the total cost or selling price. Retail markup is commonly calculated as the difference between wholesale price and retail price, as a percentage of wholesale. Other methods are also used. Price determination Profit *Assume: Sale price is 2500, Product cost is 1800 :Profit = Sale price − CostFarris P.W., Bendle N.T., Pfeifer P.E. and Reibstein D.J. (2010). Marketing metrics : The Definitive Guide to Measuring Marketing Performance, Pearson Education. :700 = 2500 − 1800 Markup Below shows markup as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Generic Trademark
A generic trademark, also known as a genericized trademark or proprietary eponym, is a trademark or brand name that, because of its popularity or significance, has become the generic term for, or synonymous with, a general class of products or services, usually against the intentions of the trademark's owner. A trademark is said to become ''genericized''—or, informally, to have suffered ''genericide''—when it begins as a distinctive product identifier but changes in meaning to become generic. This typically happens when the products or services which the trademark is associated with have acquired substantial market dominance or mind share, such that the primary meaning of the genericized trademark becomes the product or service itself rather than an indication of source for the product or service. A trademark thus popularised has its legal protection at risk in some countries such as the United States and United Kingdom, as its intellectual property rights in the trademark ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bristol Myers Squibb
The Bristol Myers Squibb Company (BMS) is an American multinational pharmaceutical company. Headquartered in New York City, BMS is one of the world's largest pharmaceutical companies and consistently ranks on the ''Fortune'' 500 list of the largest U.S. corporations. For fiscal 2021, it had a total revenue of $46.4 billion. Bristol Myers Squibb manufactures prescription pharmaceuticals and biologics in several therapeutic areas, including cancer, HIV/AIDS, cardiovascular disease, diabetes, hepatitis, rheumatoid arthritis, and psychiatric disorders. BMS's primary research and development (R&D) sites are located in Lawrence, New Jersey (formerly Squibb, near Princeton), Summit, New Jersey, formerly HQ of Celgene, New Brunswick, New Jersey, Redwood City, California, and Seville in Spain, with other sites in Devens and Cambridge, Massachusetts, East Syracuse, New York, Braine-l'Alleud, Belgium, Tokyo, Japan, Bangalore, India, and Wirral, United Kingdom. BMS previously had an R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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