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Elasticity Of Cell Membranes
A cell membrane defines a boundary between a cell and its environment. The primary constituent of a membrane is a phospholipid bilayer that forms in a water-based environment due to the hydrophilic nature of the lipid head and the hydrophobic nature of the two tails. In addition there are other lipids and proteins in the membrane, the latter typically in the form of isolated rafts. Of the numerous models that have been developed to describe the deformation of cell membranes, a widely accepted model is the fluid mosaic model proposed by Singer and Nicolson in 1972. In this model, the cell membrane surface is modeled as a two-dimensional fluid-like lipid bilayer where the lipid molecules can move freely. The proteins are partially or fully embedded in the lipid bilayer. Fully embedded proteins are called integral membrane proteins because they traverse the entire thickness of the lipid bilayer. These communicate information and matter between the interior and the exterior of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Membrane
The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures. The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. Glycolipids embedded in the outer lipid layer serve a similar purpose. The cell membrane controls the movement of substances in and out of cells and organelles, being selectively permeable to io ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mean Curvature
In mathematics, the mean curvature H of a surface S is an ''extrinsic'' measure of curvature that comes from differential geometry and that locally describes the curvature of an embedded surface in some ambient space such as Euclidean space. The concept was used by Sophie Germain in her work on elasticity theory. Jean Baptiste Marie Meusnier used it in 1776, in his studies of minimal surfaces. It is important in the analysis of minimal surfaces, which have mean curvature zero, and in the analysis of physical interfaces between fluids (such as soap films) which, for example, have constant mean curvature in static flows, by the Young-Laplace equation. Definition Let p be a point on the surface S inside the three dimensional Euclidean space . Each plane through p containing the normal line to S cuts S in a (plane) curve. Fixing a choice of unit normal gives a signed curvature to that curve. As the plane is rotated by an angle \theta (always containing the normal line) that curvatur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rubber Elasticity
Rubber elasticity refers to a property of crosslinked rubber: it can be stretched by up to a factor of 10 from its original length and, when released, returns very nearly to its original length. This can be repeated many times with no apparent degradation to the rubber. Rubber is a member of a larger class of materials called elastomers and it is difficult to overestimate their economic and technological importance. Elastomers have played a key role in the development of new technologies in the 20th century and make a substantial contribution to the global economy. Rubber elasticity is produced by several complex molecular processes and its explanation requires a knowledge of advanced mathematics, chemistry and statistical physics, particularly the concept of entropy. Entropy may be thought of as a measure of the thermal energy that is stored in a molecule. Common rubbers, such as polybutadiene and polyisoprene (also called natural rubber), are produced by a process called pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infinitesimal Strain Theory
In continuum mechanics, the infinitesimal strain theory is a mathematical approach to the description of the deformation of a solid body in which the displacements of the material particles are assumed to be much smaller (indeed, infinitesimally smaller) than any relevant dimension of the body; so that its geometry and the constitutive properties of the material (such as density and stiffness) at each point of space can be assumed to be unchanged by the deformation. With this assumption, the equations of continuum mechanics are considerably simplified. This approach may also be called small deformation theory, small displacement theory, or small displacement-gradient theory. It is contrasted with the finite strain theory where the opposite assumption is made. The infinitesimal strain theory is commonly adopted in civil and mechanical engineering for the stress analysis of structures built from relatively stiff elastic materials like concrete and steel, since a common goal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Normal (geometry)
In geometry, a normal is an object such as a line, ray, or vector that is perpendicular to a given object. For example, the normal line to a plane curve at a given point is the (infinite) line perpendicular to the tangent line to the curve at the point. A normal vector may have length one (a unit vector) or its length may represent the curvature of the object (a '' curvature vector''); its algebraic sign may indicate sides (interior or exterior). In three dimensions, a surface normal, or simply normal, to a surface at point P is a vector perpendicular to the tangent plane of the surface at P. The word "normal" is also used as an adjective: a line ''normal'' to a plane, the ''normal'' component of a force, the normal vector, etc. The concept of normality generalizes to orthogonality (right angles). The concept has been generalized to differentiable manifolds of arbitrary dimension embedded in a Euclidean space. The normal vector space or normal space of a manifold at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geodesic Torsion
In the differential geometry of surfaces, a Darboux frame is a natural moving frame constructed on a surface. It is the analog of the Frenet–Serret frame as applied to surface geometry. A Darboux frame exists at any non-umbilic point of a surface embedded in Euclidean space. It is named after French mathematician Jean Gaston Darboux. Darboux frame of an embedded curve Let ''S'' be an oriented surface in three-dimensional Euclidean space E3. The construction of Darboux frames on ''S'' first considers frames moving along a curve in ''S'', and then specializes when the curves move in the direction of the principal curvatures. Definition At each point of an oriented surface, one may attach a unit normal vector in a unique way, as soon as an orientation has been chosen for the normal at any particular fixed point. If is a curve in , parametrized by arc length, then the Darboux frame of is defined by : \mathbf(s) = \gamma'(s), (the ''unit tangent'') : \m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geodesic Curvature
In Riemannian geometry, the geodesic curvature k_g of a curve \gamma measures how far the curve is from being a geodesic. For example, for 1D curves on a 2D surface embedded in 3D space, it is the curvature of the curve projected onto the surface's tangent plane. More generally, in a given manifold \bar, the geodesic curvature is just the usual curvature of \gamma (see below). However, when the curve \gamma is restricted to lie on a submanifold M of \bar (e.g. for curves on surfaces), geodesic curvature refers to the curvature of \gamma in M and it is different in general from the curvature of \gamma in the ambient manifold \bar. The (ambient) curvature k of \gamma depends on two factors: the curvature of the submanifold M in the direction of \gamma (the normal curvature k_n), which depends only on the direction of the curve, and the curvature of \gamma seen in M (the geodesic curvature k_g), which is a second order quantity. The relation between these is k = \sqrt. In particular g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variational Calculus
The calculus of variations (or Variational Calculus) is a field of mathematical analysis that uses variations, which are small changes in functions and functionals, to find maxima and minima of functionals: mappings from a set of functions to the real numbers. Functionals are often expressed as definite integrals involving functions and their derivatives. Functions that maximize or minimize functionals may be found using the Euler–Lagrange equation of the calculus of variations. A simple example of such a problem is to find the curve of shortest length connecting two points. If there are no constraints, the solution is a straight line between the points. However, if the curve is constrained to lie on a surface in space, then the solution is less obvious, and possibly many solutions may exist. Such solutions are known as ''geodesics''. A related problem is posed by Fermat's principle: light follows the path of shortest optical length connecting two points, which depends upo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Talin (protein)
Talin is a high-molecular-weight cytoskeletal protein concentrated at regions of cell–substratum contact and, in lymphocytes, at cell–cell contacts. Discovered in 1983 by Keith Burridge and colleagues, talin is a ubiquitous cytosolic protein that is found in high concentrations in focal adhesions. It is capable of linking integrins to the actin cytoskeleton either directly or indirectly by interacting with vinculin and α-actinin. Also, talin-1 drives extravasation mechanism through engineered human microvasculature in microfluidic systems. Talin-1 is involved in each part of extravasation affecting adhesion, trans-endothelial migration and the invasion stages. Integrin receptors are involved in the attachment of adherent cells to the extracellular matrix and of lymphocytes to other cells. In these situations, talin codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, althou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Red Blood Cell
Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "hollow vessel", with ''-cyte'' translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system. RBCs take up oxygen in the lungs, or in fish the gills, and release it into tissues while squeezing through the body's capillaries. The cytoplasm of a red blood cell is rich in hemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red color of the cells and the blood. Each human red blood cell contains approximately 270 million hemoglobin molecules. The cell membrane is composed of proteins and lipids, and this structure provides properties essential for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surface Tension
Surface tension is the tendency of liquid surfaces at rest to shrink into the minimum surface area possible. Surface tension is what allows objects with a higher density than water such as razor blades and insects (e.g. water striders) to float on a water surface without becoming even partly submerged. At liquid–air interfaces, surface tension results from the greater attraction of liquid molecules to each other (due to cohesion) than to the molecules in the air (due to adhesion). There are two primary mechanisms in play. One is an inward force on the surface molecules causing the liquid to contract. Second is a tangential force parallel to the surface of the liquid. This ''tangential'' force is generally referred to as the surface tension. The net effect is the liquid behaves as if its surface were covered with a stretched elastic membrane. But this analogy must not be taken too far as the tension in an elastic membrane is dependent on the amount of deformation of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lagrange Multiplier
In mathematical optimization, the method of Lagrange multipliers is a strategy for finding the local maxima and minima of a function subject to equality constraints (i.e., subject to the condition that one or more equations have to be satisfied exactly by the chosen values of the variables). It is named after the mathematician Joseph-Louis Lagrange. The basic idea is to convert a constrained problem into a form such that the derivative test of an unconstrained problem can still be applied. The relationship between the gradient of the function and gradients of the constraints rather naturally leads to a reformulation of the original problem, known as the Lagrangian function. The method can be summarized as follows: in order to find the maximum or minimum of a function f(x) subjected to the equality constraint g(x) = 0, form the Lagrangian function :\mathcal(x, \lambda) = f(x) + \lambda g(x) and find the stationary points of \mathcal considered as a function of x and the Lagrange m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
