EPCR Challenge Cup Seasons
EPCR may refer to: * Endothelial protein C receptor, a protein encoded by the PROCR gene * ePCR (electronic polymerase chain reaction), or in silico PCR, use of software tools to calculate PCR results * European Professional Club Rugby European Professional Club Rugby (EPCR) is the governing body and organiser of the two major European rugby union club tournaments: the European Rugby Champions Cup and the European Rugby Challenge Cup. A third tournament, the European Rugby Chal ...

Endothelial Protein C Receptor
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the ''PROCR'' gene. PROCR has also recently been designated CD201 (cluster of differentiation 201). The protein encoded by this gene is a receptor for protein C that enhances its activation. Protein C is an anti-coagulant serine protease activated by the blood coagulation pathway. Structure EPCR protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. It belongs to the MHC class I/CD1 family of proteins, that is characterized by having a deep groove, that in other proteins in the family (but not in EPCR) is usually used for antigen binding. Like the CD1 series, EPCR has a lipid in the corresponding groove. The bound lipid in EPCR is usually phosphatidylcholine, but it may be phosphatidylethanolamine, and it contributes to protein C binding, though probably not through direct contact Clinical significanc ...
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In Silico PCR
In silico PCR refers to computational tools used to calculate theoretical polymerase chain reaction (PCR) results using a given set of primers ( probes) to amplify DNA sequences from a sequenced genome or transcriptome. These tools are used to optimize the design of primers for target DNA or cDNA sequences. Primer optimization has two goals: efficiency and selectivity. Efficiency involves taking into account such factors as GC-content, efficiency of binding, complementarity, secondary structure, and annealing and melting point (Tm). Primer selectivity requires that the primer pairs not fortuitously bind to random sites other than the target of interest, nor should the primer pairs bind to conserved regions of a gene family. If the selectivity is poor, a set of primers will amplify multiple products besides the target of interest. The design of appropriate short or long primer pairs is only one goal of PCR product prediction. Other information provided by ''in silico'' PCR tool ...
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