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Extreme Value Theory
Extreme value theory or extreme value analysis (EVA) is the study of extremes in statistical distributions. It is widely used in many disciplines, such as structural engineering, finance, economics, earth sciences, traffic prediction, and Engineering geology, geological engineering. For example, EVA might be used in the field of hydrology to estimate the probability of an unusually large flooding event, such as the 100-year flood. Similarly, for the design of a breakwater (structure), breakwater, a coastal engineer would seek to estimate the 50 year wave and design the structure accordingly. Data analysis Two main approaches exist for practical extreme value analysis. The first method relies on deriving block maxima (minima) series as a preliminary step. In many situations it is customary and convenient to extract the annual maxima (minima), generating an ''annual maxima series'' (AMS). The second method relies on extracting, from a continuous record, the peak values reac ...
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1755 Lisbon Earthquake
The 1755 Lisbon earthquake, also known as the Great Lisbon earthquake, impacted Portugal, the Iberian Peninsula, and Northwest Africa on the morning of Saturday, 1 November, All Saints' Day, Feast of All Saints, at around 09:40 local time. In combination with subsequent fires and a tsunami, the earthquake almost completely destroyed Lisbon and adjoining areas. Seismologists estimate the Lisbon earthquake had a magnitude of 7.7 or greater on the moment magnitude scale, with its epicenter in the Atlantic Ocean about west-southwest of Cape St. Vincent, a cape in Algarve region, and about southwest of Lisbon. Chronologically, it was the third known large-scale earthquake to hit the city (following those of 1332 and 1531 Lisbon earthquake, 1531). Estimates place the death toll in Lisbon around 30,000–40,000. A further 10,000 may have died in Morocco. The earthquake accentuated political tensions in Portugal and profoundly disrupted the Portuguese Empire. The event was widely di ...
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Wildfire
A wildfire, forest fire, or a bushfire is an unplanned and uncontrolled fire in an area of Combustibility and flammability, combustible vegetation. Depending on the type of vegetation present, a wildfire may be more specifically identified as a bushfire (Bushfires in Australia, in Australia), desert fire, grass fire, hill fire, Peat#Peat fires, peat fire, prairie fire, vegetation fire, or veld fire. Some natural forest ecosystems Fire ecology, depend on wildfire. Modern forest management often engages in prescribed burns to mitigate fire risk and promote natural forest cycles. However, controlled burns can turn into wildfires by mistake. Wildfires can be classified by cause of ignition, physical properties, combustible material present, and the effect of weather on the fire. Wildfire severity results from a combination of factors such as available fuels, physical setting, and weather. Climatic cycles with wet periods that create substantial fuels, followed by drought and heat, of ...
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Evolution
Evolution is the change in the heritable Phenotypic trait, characteristics of biological populations over successive generations. It occurs when evolutionary processes such as natural selection and genetic drift act on genetic variation, resulting in certain characteristics becoming more or less common within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation. The scientific theory of evolution by natural selection was conceived independently by two British naturalists, Charles Darwin and Alfred Russel Wallace, in the mid-19th century as an explanation for why organisms are adapted to their physical and biological environments. The theory was first set out in detail in Darwin's book ''On the Origin of Species''. Evolution by natural selection is established by observable facts about living organisms: (1) more offspring are often produced than can possibly survive; (2) phenotypic variatio ...
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Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication ( translesion synthesis). Mutations may also result from substitution, insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce detectable changes in the observable characteristics ( phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. Mutati ...
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Market Risk
Market risk is the risk of losses in positions arising from movements in market variables like prices and volatility. There is no unique classification as each classification may refer to different aspects of market risk. Nevertheless, the most commonly used types of market risk are: * '' Equity risk'', the risk that stock or stock indices (e.g. Euro Stoxx 50, etc.) prices or their implied volatility will change. * ''Interest rate risk'', the risk that interest rates (e.g. Libor, Euribor, etc.) or their implied volatility will change. * '' Currency risk'', the risk that foreign exchange rates (e.g. EUR/USD, EUR/GBP, etc.) or their implied volatility will change. * '' Commodity risk'', the risk that commodity prices (e.g. corn, crude oil) or their implied volatility will change. * '' Margining risk'' results from uncertain future cash outflows due to margin calls covering adverse value changes of a given position. * '' Shape risk'' * '' Holding period risk'' * '' Basi ...
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Equity Risk
Equity risk is "the financial risk involved in holding equity in a particular investment." Equity risk is a type of market risk that applies to investing in shares. The market price of stocks fluctuates all the time, depending on supply and demand. The risk of losing money due to a reduction in the market price of shares is known as equity risk. The measure of risk used in the equity markets is typically the standard deviation of a security's price over a number of periods. The standard deviation will delineate the normal fluctuations one can expect in that particular security above and below the mean, or average. However, since most investors would not consider fluctuations above the average return as "risk," some economists prefer other means of measuring it. Equity risk premium (ERP) is defined as "excess return that an individual stock or the overall stock market provides over a risk-free rate." equity risk premium (ERP) is the difference between the return on a market por ...
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Insurance
Insurance is a means of protection from financial loss in which, in exchange for a fee, a party agrees to compensate another party in the event of a certain loss, damage, or injury. It is a form of risk management, primarily used to protect against the risk of a contingent or uncertain loss. An entity which provides insurance is known as an insurer, insurance company, insurance carrier, or underwriter. A person or entity who buys insurance is known as a policyholder, while a person or entity covered under the policy is called an insured. The insurance transaction involves the policyholder assuming a guaranteed, known, and relatively small loss in the form of a payment to the insurer (a premium) in exchange for the insurer's promise to compensate the insured in the event of a covered loss. The loss may or may not be financial, but it must be reducible to financial terms. Furthermore, it usually involves something in which the insured has an insurable interest established by o ...
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Ximelagatran
Ximelagatran (Exanta or Exarta, H 376/95) is an anticoagulant that has been investigated extensively as a replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy. In 2006, its manufacturer AstraZeneca announced that it would withdraw pending applications for marketing approval after reports of hepatotoxicity (liver damage) during trials, and discontinue its distribution in countries where the drug had been approved (Germany, Portugal, Sweden, Finland, Norway, Iceland, Austria, Denmark, France, Switzerland, Argentina and Brazil). Method of action Ximelagatran, a direct thrombin inhibitor, was the first member of this class that can be taken orally. It acts solely by inhibiting the actions of thrombin. It is taken orally twice daily, and rapidly absorbed by the small intestine. Ximelagatran is a prodrug, being converted ''in vivo'' to the active agent melagatran. This conversion takes place in the ...
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Prescription Drug
A prescription drug (also prescription medication, prescription medicine or prescription-only medication) is a pharmaceutical drug that is permitted to be dispensed only to those with a medical prescription. In contrast, over-the-counter drugs can be obtained without a prescription. The reason for this difference in substance control is the potential scope of misuse, from drug abuse to practising medicine without a license and without sufficient education. Different jurisdictions have different definitions of what constitutes a prescription drug. In North America, , usually printed as "Rx", is used as an abbreviation of the word "prescription". It is a contraction of the Latin word "''recipe''" (an imperative form of "recipere") meaning "take". Prescription drugs are often dispensed together with a monograph (in Europe, a Patient Information Leaflet or PIL) that gives detailed information about the drug. The use of prescription drugs has been increasing since the 1960s. Regul ...
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Side Effect
In medicine, a side effect is an effect of the use of a medicinal drug or other treatment, usually adverse but sometimes beneficial, that is unintended. Herbal and traditional medicines also have side effects. A drug or procedure usually used for a specific effect may be used specifically because of a beneficial side-effect; this is termed " off-label use" until such use is approved. For instance, X-rays have long been used as an imaging technique; the discovery of their oncolytic capability led to their use in radiotherapy for ablation of malignant tumours. Frequency of side effects The World Health Organization and other health organisations characterise the probability of experiencing side effects as: * Very common, ≥ 1⁄10 * Common (frequent), 1⁄10 to 1⁄100 * Uncommon (infrequent), 1⁄100 to 1⁄1000 * Rare, 1⁄1000 to 1⁄10000 * Very rare, < 110000 The

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Population (ecology)
Population is a set of humans or other organisms in a given region or area. Governments conduct a census to quantify the resident population size within a given jurisdiction. The term is also applied to non-human animals, microorganisms, and plants, and has specific uses within such fields as ecology and genetics. Etymology The word ''population'' is derived from the Late Latin ''populatio'' (a people, a multitude), which itself is derived from the Latin word ''populus'' (a people). Use of the term Social sciences In sociology and population geography, population refers to a group of human beings with some predefined feature in common, such as location, race, ethnicity, nationality, or religion. Ecology In ecology, a population is a group of organisms of the same species which inhabit the same geographical area and are capable of interbreeding. The area of a sexual population is the area where interbreeding is possible between any opposite-sex pair within the area ...
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