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Electrical Brain Stimulation
Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy and neurotherapy used as a technique in research and clinical neurobiology to stimulate a neuron or neural network in the brain through the direct or indirect excitation of its cell membrane by using an electric current. EBS is used for research or for therapeutic purposes. History Electrical brain stimulation was first used in the first half of the 19th century by pioneering researchers such as Luigi Rolando (1773–1831) and Pierre Flourens (1794–1867), to study the brain localization of function, following the discovery by Italian physician Luigi Galvani (1737–1798) that nerves and muscles were electrically excitable. The stimulation of the surface of the cerebral cortex by using brain stimulation was used to investigate the motor cortex in animals by researchers such as Eduard Hitzig (1838–1907), Gustav Fritsch (1838–1927), David Ferrier (1842� ...
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Luigi Galvani
Luigi Galvani ( , , ; ; 9 September 1737 – 4 December 1798) was an Italian physician, physicist, biologist and philosopher who studied animal electricity. In 1780, using a frog, he discovered that the muscles of dead frogs' legs twitched when struck by an electrical spark. This was an early study of bioelectricity, following experiments by John Walsh (scientist), John Walsh and Hugh Williamson. Early life Luigi Galvani was born to Domenico Galvani and Barbara Caterina Foschi, in Bologna, then part of the Papal States. The house in which he was born may still be seen on Via Marconi, 25, in the center of Bologna. Domenico was a goldsmith. His family had produced several illustrious men. Galvani then began taking an interest in the field of "medical electricity". This field emerged in the middle of the 18th century, following electrical researches and the discovery of the effects of electricity on the human body by scientists including Bertrand Bajon and Ramón María Termey ...
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Stereotactic Method
Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc. In theory, any organ system inside the body can be subjected to stereotactic surgery. However, difficulties in setting up a reliable frame of reference (such as bone landmarks, which bear a constant spatial relation to soft tissues) mean that its applications have been, traditionally and until recently, limited to brain surgery. Besides the brain, biopsy and surgery of the breast are done routinely to locate, sample (biopsy), and remove tissue. Plain X-ray images (radiographic mammography), computed tomography, and magnetic resonance imaging can be used to guide the procedure. Another accepted form of "stereotactic" is "stereotaxic". The word roots are '' stereo-'', a prefix derive ...
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Fedor Krause
Fedor Krause (10 March 1857 – in Mieroszów, Friedland in Niederschlesien; 20 September 1937 in Bad Gastein) was a German neurosurgeon who was native of Mieroszów, Friedland (Lower Silesia). Biography He originally studied music at the Conservatoire in Berlin, and later switched to medicine, earning his doctorate at Humboldt University of Berlin, Humboldt University in Berlin. In 1883 he became a medical assistant to Richard von Volkmann (1830-1889) at the surgery, surgical university clinic at Halle, Saxony-Anhalt, Halle. Afterwards, he was a pathologist at the Senckenberg Institute in Frankfurt am Main (1890–92), a surgeon at the city hospital at Hamburg-Altona (1892-1900), and later head of the surgical department at Augusta Hospital in Berlin. In 1901 he became an associate professor at the University of Berlin. While in Berlin, he worked closely with neurologist Hermann Oppenheim (1858-1919) and he lived on island Schwanenwerder. During World War I he served as ...
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Robert Bartholow
Roberts Bartholow or Roobert Bartholow (November 28, 1831 – May 10, 1904) was an American physician and a professor at several American medical colleges. He is best known for his experiments involving a 30-year-old patient named Mary Rafferty. Rafferty was admitted to Good Samaritan Hospital in Cincinnati, Ohio in 1874 with a 2-inch-diameter (51 mm) hole in her skull caused by a cancerous ulcer. Bartholow experimented with applying current to Rafferty's exposed dura using needle electrodes. His report detailed the first observations of how electrical stimulation of the brain affects motor functions of the body, but many ethical concerns were raised about the way in which he carried out his experiments. Rafferty went into a coma for three days and then died the day after coming out of the coma from a massive seizure. Education and career Roberts Bartholow was born in New Windsor, Maryland. He attended Calvert College in his hometown, and graduated in 1848 with a Bachel ...
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Neurologist
Neurology (from , "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous system, which comprises the brain, the spinal cord and the peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system, using various techniques of neurotherapy. IEEE Brain (2019). "Neurotherapy: Treating Disorders by Retraining the Brain". ''The Future Neural Therapeutics White Paper''. Retrieved 23.01.2025 from: https://brain.ieee.org/topics/neurotherapy-treating-disorders-by-retraining-the-brain/#:~:text=Neurotherapy%20trains%20a%20patient's%20brain,wave%20activity%20through%20positive%20reinforcement International Neuromodulation Society, Retrieved 23 January 2025 from: https://www.neuromodulation.com/ Val Danilov I (2023). "The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brai ...
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Neurosurgeon
Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty that focuses on the surgical treatment or rehabilitation of disorders which affect any portion of the nervous system including the brain, spinal cord, peripheral nervous system, and cerebrovascular system. Neurosurgery as a medical specialty also includes non-surgical management of some neurological conditions. Education and context In different countries, there are different requirements for an individual to legally practice neurosurgery, and there are varying methods through which they must be educated. In most countries, neurosurgeon training requires a minimum period of seven years after graduating from medical school. United Kingdom In the United Kingdom, students must gain entry into medical school. The MBBS qualification (Bachelor of Medicine, Bachelor of Surgery) takes four to six years depending on the student's route. The newly qualified physician must then comple ...
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Friedrich Goltz
Friedrich Leopold Goltz (14 August 1834 – 5 May 1902) was a German physiologist and nephew of the writer Bogumil Goltz. Biography Born in Posen (Poznań), Grand Duchy of Posen, he studied medicine at the University of Königsberg, and following two years of surgical training, served as a prosector of anatomy in Königsberg. In 1870 he succeeded A.W. Volkmann as professor of physiology at the University of Halle, followed by a professorship at the University of Straßburg (from 1872).Virtual Laboratory
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David Ferrier
Sir David Ferrier FRS (13 January 1843 – 19 March 1928) was a pioneering Scottish neurologist and psychologist. Ferrier conducted experiments on the brains of animals such as monkeys and in 1881 became the first scientist to be prosecuted under the Cruelty to Animals Act, 1876 which had been enacted following a major public debate over vivisection. Life Ferrier was born in Woodside, Aberdeen, the sixth child of David and Hannah; he was educated at Aberdeen Grammar School before studying for an MA at Aberdeen University (graduating in Classics in 1863), before studying psychophysiology in Germany and medicine at Edinburgh. As a medical student, he began to work as a scientific assistant to the influential free-thinking philosopher and psychologist Alexander Bain (1818–1903), one of the founders of associative psychology. Around 1860, psychology was finding its scientific foundation mainly in Germany, with the rigorous research of Hermann von Helmholtz (1821–1 ...
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Gustav Fritsch
Gustav Theodor Fritsch (5 March 1838 – 12 June 1927) was a German anatomist, anthropologist, traveller and physiologist from Cottbus. Fritsch studied natural science and medicine in Berlin, Breslau and Heidelberg. In 1874 he became an associate professor of physiology at the University of Berlin, where he was later appointed head of the histology, histological department at the physiological institute. He is known for his work with neuropsychiatrist Eduard Hitzig (1839–1907) involving the localization of brain function, localization of the motor areas of cerebral cortex, motor areas of the brain. In 1870, the two scientists probed the cerebral cortex of a dog to discover that electrical stimulation of different areas of the cerebrum caused involuntary muscular contractions of specific parts of the dog's body. Along with his medical studies, Fritsch was also known for his ethnography, ethnographical research in southern Africa (1863–66), during which time he traveled fr ...
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Eduard Hitzig
Eduard Hitzig (6 February 1838 – 20 August 1907) was a German neurologist and neuropsychiatrist of Jewish ancestryAndrew P. Wickens, ''A History of the Brain: From Stone Age Surgery to Modern Neuroscience'', Psychology Press (2014), p. 226 born in Berlin. Eduard was the son of Friedrich Hitzig and his grandfather had converted to Protestantism. He studied medicine at the Universities of Berlin and Würzburg under the instruction of famous men such as Emil Du Bois-Reymond (1818–1896), Rudolf Virchow (1821–1902), Moritz Heinrich Romberg (1795–1873), and Karl Friedrich Otto Westphal (1833–1890). He received his doctorate in 1862 and subsequently worked in Berlin and Würzburg. In 1875, he became director of the Burghölzli asylum, as well as professor of psychiatry at the University of Zurich. In 1885, Hitzig became a professor at the University of Halle where he remained until his retirement in 1903. Hitzig is remembered for his work concerning the interaction ...
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Motor Cortex
The motor cortex is the region of the cerebral cortex involved in the planning, motor control, control, and execution of voluntary movements. The motor cortex is an area of the frontal lobe located in the posterior precentral gyrus immediately anterior to the central sulcus. Components The motor cortex can be divided into three areas: 1. The primary motor cortex is the main contributor to generating neural impulses that pass down to the spinal cord and control the execution of movement. However, some of the other motor areas in the brain also play a role in this function. It is located on the anterior paracentral lobule on the medial surface. 2. The premotor cortex is responsible for some aspects of motor control, possibly including the preparation for movement, the sensory guidance of movement, the spatial guidance of reaching, or the direct control of some movements with an emphasis on control of proximal and trunk muscles of the body. Located anterior to the primary mo ...
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