E64
E64 may refer to: * BMW E64, a car model in the BMW 6 Series * European route E64, a series of roads in Italy, part of the United Nations International E-road network * E-64, an epoxide which can irreversibly inhibit a wide range of cysteine peptidases * King's Indian Defence, Encyclopaedia of Chess Openings code * Tsugaru Expressway The is a two-lane expressway, two-lane national Expressways of Japan, expressway in Aomori Prefecture, Japan. The expressway connects the prefecture's capital, Aomori, Aomori, Aomori, and the Tōhoku Expressway to the municipalities of Goshogawara ...

BMW E64
The second generation of the BMW 6 Series consists of the BMW E63 (coupe version) and BMW E64 (convertible version) grand tourers. The E63/E64 generation was produced by BMW from 2003 to 2010 and is often collectively referred to as the E63. The E63 uses a shortened version of the E60 5 Series chassis and subsequently shares many features. The car initially drew criticism, due to its controversial styling and complicated iDrive system. The M6 model was introduced in 2005 in coupé and convertible body styles. It is powered by the S85 V10 engine shared with the E60 M5, and most M6s were produced with a 7-speed automated manual transmission ("SMG III"). In March 2011, the BMW 6 Series (F06/F12/F13) began production as the successor to the E63. Development and launch The exterior was designed by Adrian van Hooydonk, based on the 1999 BMW Z9 concept car designed by the then BMW Design Chief Chris Bangle. The controversial rear styling, first seen on the E65 7 Series, was ...
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European Route E64
European route E 64 is a series of roads in Italy, part of the United Nations International E-road network. It runs from Turin to Brescia, both in Italy. Firstly it leaves Turin (in Piedmont), heading northeast into Lombardy and passing through Milan. It then continues north-east until it reaches its final destination of Brescia. Connections with other E-roads * At Turin, it connects to the E 70, the E 612, and the E 717. * Upon reaching Milan, it makes a connection to both the E 35 and the E 62. * When it finishes at Brescia Brescia (, locally ; lmo, link=no, label= Lombard, Brèsa ; lat, Brixia; vec, Bressa) is a city and ''comune'' in the region of Lombardy, Northern Italy. It is situated at the foot of the Alps, a few kilometers from the lakes Garda and Iseo ..., it links with European Route E 70. External links UN Economic Commission for Europe: Overall Map of E-road Network (2007) 64 E064 {{Italy-road-stub ...
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King's Indian Defence
The King's Indian Defence is a common chess opening. It is defined by the following moves: :1. d4 Nf6 :2. c4 g6 Black intends to follow up with 3...Bg7 and 4...d6 (the Grünfeld Defence arises when Black plays 3...d5 instead, and is considered a separate opening). White's major third move options are 3.Nc3, 3.Nf3 or 3.g3, with both the King's Indian and Grünfeld playable against these moves. The ''Encyclopaedia of Chess Openings'' classifies the King's Indian Defence under the codes E60 through E99. The King's Indian is a hypermodern opening, where Black deliberately allows White control of the with its pawns, with the view to subsequently challenge it. In the most critical lines of the King's Indian, White erects an imposing pawn centre with Nc3 followed by e4. Black stakes out its own claim to the centre with the Benoni-style ...c5, or ...e5. If White resolves the central pawn tension with d5, then Black follows with either ...b5 and queenside play, or ...f5 and an ...
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E-64
E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases. The compound was first isolated and identified from ''Aspergillus japonicus'' in 1978. It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain. The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause. Structure and mechanism of inhibition E-64 possesses a ''trans''-epoxysuccinic acid group coupled to a modified dipeptide. The covalent attachment of E-64 to the active site cysteine occurs via nucleophillic attack from the thiol In organic chemistry, a thiol (; ), or thiol derivative, is any organosulfur compound of the form , where R represents an alkyl or other organic substituent. The functional group itself is referred to as either a thiol group or a sulfh ...
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