Diosmectite
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Diosmectite
Diosmectite (brand names Smecta, Smecdral) is a natural silicate of aluminium and magnesium used as an intestinal adsorbent in the treatment of several gastrointestinal diseases, including infectious and non-infectious acute and chronic diarrhoea, including irritable bowel syndrome diarrhea subtype. Other uses include: chronic diarrhea caused by radiation-induced, chemotherapy-induced, and HIV/AIDS-associated chronic diarrhea. It is insoluble in water. It is usually taken orally as a suspension in warm water. In the field of geology, it is more commonly known as montmorillonite. Diosmectite is a contraction of " dioctahedral smectite A smectite (from ancient Greek ''σμηκτός'' smektos 'lubricated'; ''σμηκτρίς'' smektris 'walker's earth', 'fuller's earth'; rubbing earth; earth that has the property of cleaning) is a mineral mixtures of various swelling sheet sil ...". Mechanism of action Its effectiveness in improving stool consistency is the result of its abilit ...
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Diarrhoea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin with loss of the normal stretchiness of the skin and irritable behaviour. This can progress to decreased urination, loss of skin color, a fast heart rate, and a decrease in responsiveness as it becomes more severe. Loose but non-watery stools in babies who are exclusively breastfed, however, are normal. The most common cause is an infection of the intestines due to either a virus, bacterium, or parasite—a condition also known as gastroenteritis. These infections are often acquired from food or water that has been contaminated by feces, or directly from another person who is infected. The three types of diarrhea are: short duration watery diarrhea, short duration bloody diarrhea, and persistent diarrhea (lasting more than two weeks, ...
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Medicinal Clay
The use of medicinal clay in folk medicine goes back to prehistoric times. Indigenous peoples around the world still use clay widely, which is related to geophagy. The first recorded use of medicinal clay goes back to ancient Mesopotamia. A wide variety of clays are used for medicinal purposes—primarily for external applications, such as the clay baths in health spas ( mud therapy). Among the clays most commonly used are kaolin and the smectite clays such as bentonite, montmorillonite, and Fuller's earth. History Ancient Egypt and Mesopotamia The first recorded use of medicinal clay is on Mesopotamian clay tablets around 2500 B.C. Also, ancient Egyptians used clay. The Pharaohs’ physicians used the material as anti-inflammatory agents and antiseptics. It was used as a preservative for making mummies and is also reported that Cleopatra used clays to preserve her complexion. The Ebers Papyrus of about 1550 BC (but containing the tradition going back many centuries earlier ...
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Silicate
In chemistry, a silicate is any member of a family of polyatomic anions consisting of silicon and oxygen, usually with the general formula , where . The family includes orthosilicate (), metasilicate (), and pyrosilicate (, ). The name is also used for any salt of such anions, such as sodium metasilicate; or any ester containing the corresponding chemical group, such as tetramethyl orthosilicate. The name "silicate" is sometimes extended to any anions containing silicon, even if they do not fit the general formula or contain other atoms besides oxygen; such as hexafluorosilicate .Most commonly, silicates are encountered as silicate minerals. For diverse manufacturing, technological, and artistic needs, silicates are versatile materials, both natural (such as granite, gravel, and garnet) and artificial (such as Portland cement, ceramics, glass, and waterglass). Structural principles In all silicates, silicon atom occupies the center of an idealized tetrahedron whose c ...
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Montmorillonite
Montmorillonite is a very soft phyllosilicate group of minerals that form when they precipitate from water solution as microscopic crystals, known as clay. It is named after Montmorillon in France. Montmorillonite, a member of the smectite group, is a 2:1 clay, meaning that it has two tetrahedral sheets of silica sandwiching a central octahedral sheet of alumina. The particles are plate-shaped with an average diameter around 1 μm and a thickness of 0.96 nm; magnification of about 25,000 times, using an electron microscope, is required to "see" individual clay particles. Members of this group include, amongst others, saponite, nontronite, beidellite, and hectorite. Montmorillonite is a subclass of smectite, a 2:1 phyllosilicate mineral characterized as having greater than 50% octahedral charge; its cation exchange capacity is due to isomorphous substitution of Mg for Al in the central alumina plane. The substitution of lower valence cations in such instances leaves the n ...
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Geophagy
Geophagia (), also known as geophagy (), is the intentional practice of eating earth or soil-like substances such as clay, chalk, or termite mounds. It is a behavioural adaptation that occurs in many non-human animals and has been documented in more than 100 primate species. Geophagy in non-human primates is primarily used for protection from parasites, minerals supplements and helps metabolize toxic compounds from leaves. Geophagy also occurs in humans and is most commonly reported among children and pregnant women. Human geophagia is a form of pica – the craving and purposive consumption of non-food items – and is classified as an eating disorder in the '' Diagnostic and Statistical Manual of Mental Disorders'' (DSM) if not socially or culturally appropriate. Sometimes geophagy is a consequence of carrying a hookworm infection. Although its etiology remains unknown, geophagy has many potential adaptive health benefits as well as negative consequences. Animals Geophag ...
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Antigens
In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. The term ''antigen'' originally referred to a substance that is an antibody generator. Antigens can be proteins, peptides (amino acid chains), polysaccharides (chains of monosaccharides/simple sugars), lipids, or nucleic acids. Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. Diverse antigen receptors are made by cells of the immune system so that each cell has a specificity for a single antigen. Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as clonal selection. In most cases, an antibody can only react to and bind one specific antigen; in some instances, however, antibodies may cross-react and bind more than one antigen. ...
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Lumen (anatomy)
In biology, a lumen (plural lumina) is the inside space of a tubular structure, such as an artery or intestine. It comes . It can refer to: *The interior of a vessel, such as the central space in an artery, vein or capillary through which blood flows. *The interior of the gastrointestinal tract *The pathways of the bronchi in the lungs *The interior of renal tubules and urinary collecting ducts *The pathways of the female genital tract, starting with a single pathway of the vagina, splitting up in two lumina in the uterus, both of which continue through the Fallopian tubes In cell biology, a lumen is a membrane-defined space that is found inside several organelles, cellular components, or structures: * thylakoid, endoplasmic reticulum, Golgi apparatus, lysosome, mitochondrion, or microtubule Transluminal procedures ''Transluminal procedures'' are procedures occurring through lumina, including: * Natural orifice transluminal endoscopic surgery in the lumina of, for exa ...
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Smectite
A smectite (from ancient Greek ''σμηκτός'' smektos 'lubricated'; ''σμηκτρίς'' smektris 'walker's earth', 'fuller's earth'; rubbing earth; earth that has the property of cleaning) is a mineral mixtures of various swelling sheet silicates (phyllosilicates), which have a three-layer 2:1 (TOT) structure and belong to the clay minerals. Smectites mainly consist of montmorillonite, but can often contain secondary minerals such as quartz and calcite. Terminology In clay mineralogy, smectite is synonym of montmorillonite (also the name of a pure clay mineral phase) to indicate a class of swelling clays. The term smectite is commonly used in Europe and in the UK while the term montmorillonite is preferred in North America, but both terms are equivalent and can be used interchangeably. For industrial and commercial applications, the term bentonite is mostly used in place of smectite or montmorillonite. Mineralogical structure The 2:1 layer (TOT) structure consists of tw ...
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Insoluble
In chemistry, solubility is the ability of a substance, the solute, to form a solution with another substance, the solvent. Insolubility is the opposite property, the inability of the solute to form such a solution. The extent of the solubility of a substance in a specific solvent is generally measured as the concentration of the solute in a saturated solution, one in which no more solute can be dissolved. At this point, the two substances are said to be at the solubility equilibrium. For some solutes and solvents, there may be no such limit, in which case the two substances are said to be "miscible in all proportions" (or just "miscible"). The solute can be a solid, a liquid, or a gas, while the solvent is usually solid or liquid. Both may be pure substances, or may themselves be solutions. Gases are always miscible in all proportions, except in very extreme situations,J. de Swaan Arons and G. A. M. Diepen (1966): "Gas—Gas Equilibria". ''Journal of Chemical Physics'', ...
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Aluminium
Aluminium (aluminum in American and Canadian English) is a chemical element with the symbol Al and atomic number 13. Aluminium has a density lower than those of other common metals, at approximately one third that of steel. It has a great affinity towards oxygen, and forms a protective layer of oxide on the surface when exposed to air. Aluminium visually resembles silver, both in its color and in its great ability to reflect light. It is soft, non-magnetic and ductile. It has one stable isotope, 27Al; this isotope is very common, making aluminium the twelfth most common element in the Universe. The radioactivity of 26Al is used in radiodating. Chemically, aluminium is a post-transition metal in the boron group; as is common for the group, aluminium forms compounds primarily in the +3 oxidation state. The aluminium cation Al3+ is small and highly charged; as such, it is polarizing, and bonds aluminium forms tend towards covalency. The strong affinity tow ...
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HIV/AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to ch ...
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