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Digitalis Obscura
''Digitalis obscura'', commonly called willow-leaved foxglove or dusty foxglove or spanish rusty foxglove, is a flowering plant native to regions in Spain and Morocco. It is also grown as an ornamental flower. This foxglove is a woody perennial plant belonging to the family Plantaginaceae. Along with the other foxgloves it used to be placed in the figwort family, Scrophulariaceae; however, recent genetic research has moved the genus ''Digitalis'' to a larger family. It is similar to many of the foxglove species in its high toxicity and medicinal use as a source for the heart-regulating drug digoxin. Its strikingly distinctive amber- to copper-coloured flowers give the species its name and help distinguish it from other members of the genus. Distribution ''Digitalis obscura'' is native to the western Mediterranean in eastern and southern Spain and northern Morocco, where it is found growing in dry, open woods and often on limestone. ''Digitalis obscura'' subsp. ''laciniata'' is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carl Linnaeus
Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the modern system of naming organisms. He is known as the "father of modern taxonomy". Many of his writings were in Latin; his name is rendered in Latin as and, after his 1761 ennoblement, as . Linnaeus was born in Råshult, the countryside of Småland, in southern Sweden. He received most of his higher education at Uppsala University and began giving lectures in botany there in 1730. He lived abroad between 1735 and 1738, where he studied and also published the first edition of his ' in the Netherlands. He then returned to Sweden where he became professor of medicine and botany at Uppsala. In the 1740s, he was sent on several journeys through Sweden to find and classify plants and animals. In the 1750s and 1760s, he continued to collect an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hummingbird
Hummingbirds are birds native to the Americas and comprise the biological family Trochilidae. With about 361 species and 113 genera, they occur from Alaska to Tierra del Fuego, but the vast majority of the species are found in the tropics around the equator. They are small birds, with most species measuring in length. The smallest extant hummingbird species is the bee hummingbird, which weighs less than . The largest hummingbird species is the giant hummingbird, weighing . They are specialized for feeding on flower nectar, but all species also consume flying insects or spiders. Hummingbirds split from their sister group, the swifts and treeswifts, around 42 million years ago. The common ancestor of extant hummingbirds is estimated to have lived 22 million years ago in South America. They are known as hummingbirds because of the humming sound created by their beating wings, which flap at high frequencies audible to humans. They hover in mid-air at rapid wing-flapping rate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Arrest
Cardiac arrest is when the heart suddenly and unexpectedly stops beating. It is a medical emergency that, without immediate medical intervention, will result in sudden cardiac death within minutes. Cardiopulmonary resuscitation (CPR) and possibly defibrillation are needed until further treatment can be provided. Cardiac arrest results in a rapid loss of consciousness, and breathing may be abnormal or absent. While cardiac arrest may be caused by heart attack or heart failure, these are not the same, and in 15 to 25% of cases, there is a non-cardiac cause. Some individuals may experience chest pain, shortness of breath, nausea, an elevated heart rate, and a light-headed feeling immediately before entering cardiac arrest. The most common cause of cardiac arrest is an underlying heart problem like coronary artery disease that decreases the amount of oxygenated blood supplying the heart muscle. This, in turn, damages the structure of the muscle, which can alter its function. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aglycones
An aglycone (aglycon or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for c ... would be a steroid molecule. Detection A way to identify aglycone is proposed to extract it from Agave spp. by using H-NMR and Heteronuclear multiple bond correlation (HMBC) experiments. The HMBC experiment can be combined with other techniques such as mass spectrometry to further examine the structure and the function of aglycone. Samples of glycones and glycosides from limonoids can be simultaneously quantified through a high performance liquid chromatography (HPLC) method, where a binary solvent system and a diode array detector separate and detect th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gitoxin
Gitoformate (INN, or pentaformylgitoxin, trade name Dynocard) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Produced by Madaus, it is not available in the US, and does not seem to be available in Europe either. Chemistry Gitoformate is a derivative of the glycoside gitoxin, with five of the six free hydroxyl groups formylated, one on the aglycon An aglycone (aglycon or genin) is the compound remaining after the glycosyl group on a glycoside is replaced by a hydrogen atom. For example, the aglycone of a cardiac glycoside Cardiac glycosides are a class of organic compounds that increase ... and four on the sugar. Gitoxin, a cardiac glycoside from the woolly foxglove (''Digitalis lanata''), has an aglycon of the cardenolide type named gitoxigenin, which is also the aglycon of lanatoside B, another ''Digitalis lanata'' glycoside. References Cardenolides Formate este ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digitonin
Digitonin is a steroidal saponin (saraponin) obtained from the foxglove plant ''Digitalis purpurea''. Its aglycone is digitogenin, a spirostan steroid. It has been investigated as a detergent, as it effectively water-solubilizes lipids. As such, it has several potential membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. Digitonin is sometimes confused with the cardiac drugs digoxin and digitoxin; all three can be extracted from the same source. Chemical properties * Critical micelle concentration = < 0.5 mM * Average micellar weight = 70000 * Aggregation number An aggregation number is a description of the number of molecules present in a micelle once the critical micelle concentration (CMC) has been reached. In more detail, ...
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Digitalin
Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart disease, heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and blood pressure, reducing heart rate, and somewhat extending the time frame of the contraction. Digoxin is taken by mouth or by intravenous, injection into a vein. Digoxin has a half life of approximately 36 hours given at average doses in patients with normal renal function. It is excreted mostly unchanged in the urine. Common side effects include gynecomastia, breast enlargement with other side effects generally due to an excessive dose. These side effects may include loss of appetite, nausea, trouble seeing, confusion, and an Heart arrhythmia, irregular heartbeat. Greater care is require ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digitoxin
Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting. Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective. Medical uses Digitoxin is used for the treatment of heart failure, especially in people with impaired kidney function. It is also used to treat certain kinds of heart arrhythmia, such as atrial fibrillation. Contraindications Contraindications include * problems with the heart rhythm, such as severe bradycardia (slow heartbeat), ventricular tachycardia (fast heartbeat caused ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiac Glycosides
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump. Their beneficial medical uses are as treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used. Most commonly found as secondary metabolites in several plants such as foxglove plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment. Classification General structure The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar (glycoside) and an R group. The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity. Cardiac glycosi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Province Of Granada
Granada is a province of southern Spain, in the eastern part of the autonomous community of Andalusia. It is bordered by the provinces of Albacete, Murcia, Almería, Jaén, Córdoba, Málaga, and the Mediterranean Sea (along the Costa Tropical). Its capital city is also called Granada. The province covers an area of . Its population was 921,338 , of whom about 30% live in the capital, and its average population density is . It contains 170 municipalities. Geography The tallest mountain in the Iberian Peninsula, Mulhacén, is located in Granada. It measures . The next highest mountains in the province are Veleta () and Alcazaba (). The river Genil, which rises in Granada, is one of the main tributaries of the Guadalquivir. Other important rivers include the Fardes, Monachil, Guadalfeo, Dílar, Ízbor, Verde and Darro. Granada shares the Sierra Nevada National Park (in the Sierra Nevada mountain range) with Almería province. Another important range is the Sierra de Baza. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
