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Digital Microfluidics
Digital microfluidics (DMF) is a platform for lab-on-a-chip systems that is based upon the manipulation of microdroplets. Droplets are dispensed, moved, stored, mixed, reacted, or analyzed on a platform with a set of insulated electrodes. Digital microfluidics can be used together with analytical analysis procedures such as mass spectrometry, colorimetry, electrochemical, and electrochemiluminescense. Overview ] In analogy to digital microelectronics, digital microfluidic operations can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. And in contrast to continuous-flow microfluidics, digital microfluidics works much the same way as traditional bench-top protocols, only with much smaller volumes and much higher automation. Thus a wide range of established chemical procedures and protocols can be seamlessly transferred to a nanoliter droplet format. Electrowetting, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polydimethylsiloxane
Polydimethylsiloxane (PDMS), also known as dimethylpolysiloxane or dimethicone, belongs to a group of polymeric organosilicon compounds that are commonly referred to as silicones. PDMS is the most widely used silicon-based organic polymer, as its versatility and properties lead to many applications. It is particularly known for its unusual rheological (or flow) properties. PDMS is optically clear and, in general, inert, non-toxic, and non-flammable. It is one of several types of silicone oil (polymerized siloxane). Its applications range from contact lenses and medical devices to elastomers; it is also present in shampoos (as it makes hair shiny and slippery), food (antifoaming agent), caulk, lubricants and heat-resistant tiles. Structure The chemical formula of PDMS is , where ''n'' is the number of repeating monomer units.Mark, J. E.; Allcock, H. R.; West, R. “Inorganic Polymers” Prentice Hall, Englewood, NJ: 1992. . Industrial synthesis can begin from dimethyldichloro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digital Microfluidics
Digital microfluidics (DMF) is a platform for lab-on-a-chip systems that is based upon the manipulation of microdroplets. Droplets are dispensed, moved, stored, mixed, reacted, or analyzed on a platform with a set of insulated electrodes. Digital microfluidics can be used together with analytical analysis procedures such as mass spectrometry, colorimetry, electrochemical, and electrochemiluminescense. Overview ] In analogy to digital microelectronics, digital microfluidic operations can be combined and reused within hierarchical design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. And in contrast to continuous-flow microfluidics, digital microfluidics works much the same way as traditional bench-top protocols, only with much smaller volumes and much higher automation. Thus a wide range of established chemical procedures and protocols can be seamlessly transferred to a nanoliter droplet format. Electrowetting, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EWOD
Electrowetting is the modification of the wetting properties of a surface (which is typically hydrophobic) with an applied electric field. History The electrowetting of mercury and other liquids on variably charged surfaces was probably first explained by Gabriel Lippmann in 1875 and was certainly observed much earlier. A. N. Frumkin used surface charge to change the shape of water drops in 1936. The term electrowetting was first introduced in 1981 by G. Beni and S. Hackwood to describe an effect proposed for designing a new type of display device for which they received a patent. The use of a "fluid transistor" in microfluidic circuits for manipulating chemical and biological fluids was first investigated by J. Brown in 1980 and later funded in 1984–1988 under NSF Grants 8760730 & 8822197, employing insulating dielectric and hydrophobic layer(s) (EWOD), immiscible fluids, DC or RF power; and mass arrays of miniature interleaved (saw tooth) electrodes with large or matching Indi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vacuum Permittivity
Vacuum permittivity, commonly denoted (pronounced "epsilon nought" or "epsilon zero"), is the value of the absolute dielectric permittivity of classical vacuum. It may also be referred to as the permittivity of free space, the electric constant, or the distributed capacitance of the vacuum. It is an ideal (baseline) physical constant. Its CODATA value is: : ( farads per meter), with a relative uncertainty of It is a measure of how dense of an electric field is "permitted" to form in response to electric charges, and relates the units for electric charge to mechanical quantities such as length and force. For example, the force between two separated electric charges with spherical symmetry (in the vacuum of classical electromagnetism) is given by Coulomb's law: :F_\text = \frac \frac Here, ''q''1 and ''q''2 are the charges, ''r'' is the distance between their centres, and the value of the constant fraction 1/4 \pi \varepsilon_0 (known as the Coulomb constant, ''k''e) is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Permittivity
In electromagnetism, the absolute permittivity, often simply called permittivity and denoted by the Greek letter ''ε'' ( epsilon), is a measure of the electric polarizability of a dielectric. A material with high permittivity polarizes more in response to an applied electric field than a material with low permittivity, thereby storing more energy in the material. In electrostatics, the permittivity plays an important role in determining the capacitance of a capacitor. In the simplest case, the electric displacement field D resulting from an applied electric field E is :\mathbf = \varepsilon \mathbf. More generally, the permittivity is a thermodynamic function of state. It can depend on the frequency, magnitude, and direction of the applied field. The SI unit for permittivity is farad per meter (F/m). The permittivity is often represented by the relative permittivity ''ε''r which is the ratio of the absolute permittivity ''ε'' and the vacuum permittivity ''ε''0 :\kappa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EWOD Unbold
Electrowetting is the modification of the wetting properties of a surface (which is typically hydrophobic) with an applied electric field. History The electrowetting of mercury and other liquids on variably charged surfaces was probably first explained by Gabriel Lippmann in 1875 and was certainly observed much earlier. A. N. Frumkin used surface charge to change the shape of water drops in 1936. The term electrowetting was first introduced in 1981 by G. Beni and S. Hackwood to describe an effect proposed for designing a new type of display device for which they received a patent. The use of a "fluid transistor" in microfluidic circuits for manipulating chemical and biological fluids was first investigated by J. Brown in 1980 and later funded in 1984–1988 under NSF Grants 8760730 & 8822197, employing insulating dielectric and hydrophobic layer(s) (EWOD), immiscible fluids, DC or RF power; and mass arrays of miniature interleaved (saw tooth) electrodes with large or matching Indi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrophobicity
In chemistry, hydrophobicity is the physical property of a molecule that is seemingly repelled from a mass of water (known as a hydrophobe). In contrast, hydrophiles are attracted to water. Hydrophobic molecules tend to be nonpolar and, thus, prefer other neutral molecules and nonpolar solvents. Because water molecules are polar, hydrophobes do not dissolve well among them. Hydrophobic molecules in water often cluster together, forming micelles. Water on hydrophobic surfaces will exhibit a high contact angle. Examples of hydrophobic molecules include the alkanes, oils, fats, and greasy substances in general. Hydrophobic materials are used for oil removal from water, the management of oil spills, and chemical separation processes to remove non-polar substances from polar compounds. Hydrophobic is often used interchangeably with lipophilic, "fat-loving". However, the two terms are not synonymous. While hydrophobic substances are usually lipophilic, there are exceptions, suc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contact Angle
The contact angle is the angle, conventionally measured through the liquid, where a liquid–vapor interface meets a solid surface. It quantifies the wettability of a solid surface by a liquid via the Young equation. A given system of solid, liquid, and vapor at a given temperature and pressure has a unique equilibrium contact angle. However, in practice a dynamic phenomenon of contact angle hysteresis is often observed, ranging from the advancing (maximal) contact angle to the receding (minimal) contact angle. The equilibrium contact is within those values, and can be calculated from them. The equilibrium contact angle reflects the relative strength of the liquid, solid, and vapour molecular interaction. The contact angle depends upon the medium above the free surface of the liquid, and the nature of the liquid and solid in contact. It is independent of the inclination of solid to the liquid surface. It changes with surface tension and hence with the temperature and purity of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surface Tension
Surface tension is the tendency of liquid surfaces at rest to shrink into the minimum surface area possible. Surface tension is what allows objects with a higher density than water such as razor blades and insects (e.g. water striders) to float on a water surface without becoming even partly submerged. At liquid–air interfaces, surface tension results from the greater attraction of liquid molecules to each other (due to cohesion) than to the molecules in the air (due to adhesion). There are two primary mechanisms in play. One is an inward force on the surface molecules causing the liquid to contract. Second is a tangential force parallel to the surface of the liquid. This ''tangential'' force is generally referred to as the surface tension. The net effect is the liquid behaves as if its surface were covered with a stretched elastic membrane. But this analogy must not be taken too far as the tension in an elastic membrane is dependent on the amount of deformation of the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photoelectrowetting
Photoelectrowetting is a modification of the wetting properties of a surface (typically a hydrophobic surface) using incident light. Working principle Whereas ordinary electrowetting is observed in surfaces consisting of a liquid/ insulator/ conductor stack, photoelectrowetting can be observed by replacing the conductor with a semiconductor to form a liquid/insulator/semiconductor stack. This has electrical and optical properties similar to the metal/insulator/semiconductor stack used in metal-oxide-semiconductor field effect transistors (MOSFETs) and charge-coupled devices (CCDs). Replacing the conductor with a semiconductor results in asymmetrical electrowetting behavior (in terms of voltage polarity), depending on the semiconductor doping type and density. Incident light above the semiconductor's band gap creates photo-induced carriers via electron-hole pair generation in the depletion region of the underlying semiconductor. This leads to a modification of the capacitance o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Photoconductivity
Photoconductivity is an optical and electrical phenomenon in which a material becomes more electrically conductive due to the absorption of electromagnetic radiation such as visible light, ultraviolet light, infrared light, or gamma radiation. When light is absorbed by a material such as a semiconductor, the number of free electrons and holes increases, resulting in increased electrical conductivity. To cause excitation, the light that strikes the semiconductor must have enough energy to raise electrons across the band gap, or to excite the impurities within the band gap. When a bias voltage and a load resistor are used in series with the semiconductor, a voltage drop across the load resistors can be measured when the change in electrical conductivity of the material varies the current through the circuit. Classic examples of photoconductive materials include: * photographic film: Kodachrome, Fujifilm, Agfachrome, Ilford, ''etc.'', based on silver sulfide and silver bromide. * th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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