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Dictyosteliidae
The dictyostelids (Dictyostelia/Dictyostelea, International Code of Zoological Nomenclature, ICZN, or Dictyosteliomycetes, ICBN) are a group of cellular slime molds, or social amoebae. Multicellular behavior When food (normally bacteria) is readily available dictyostelids behave as individual amoebae, which feed and divide normally. However, when the food supply is exhausted, they aggregate to form a multicellular assembly, called a pseudoplasmodium, Grex (biology), grex, or slug (not to be confused with the gastropoda, gastropod mollusca, mollusc called a slug). The grex has a definite anterior and posterior, responds to light and temperature gradients, and has the ability to migrate. Under the correct circumstances the grex matures forming a sorocarp (fruiting body) with a stalk supporting one or more Sorus, sori (balls of spores). These spores are inactive cells protected by resistant cell walls, and become new amoebae once food is available. In ''Acytostelium'', the soro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dictyosteliales
The dictyostelids (Dictyostelia/Dictyostelea, International Code of Zoological Nomenclature, ICZN, or Dictyosteliomycetes, ICBN) are a group of cellular slime molds, or social amoebae. Multicellular behavior When food (normally bacteria) is readily available dictyostelids behave as individual amoebae, which feed and divide normally. However, when the food supply is exhausted, they aggregate to form a multicellular assembly, called a pseudoplasmodium, Grex (biology), grex, or slug (not to be confused with the gastropoda, gastropod mollusca, mollusc called a slug). The grex has a definite anterior and posterior, responds to light and temperature gradients, and has the ability to migrate. Under the correct circumstances the grex matures forming a sorocarp (fruiting body) with a stalk supporting one or more Sorus, sori (balls of spores). These spores are inactive cells protected by resistant cell walls, and become new amoebae once food is available. In ''Acytostelium'', the soro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dictyostelium Discoideum
''Dictyostelium discoideum'' is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. Commonly referred to as slime mold, ''D. discoideum'' is a eukaryote that transitions from a collection of unicellular amoebae into a multicellular slug and then into a fruiting body within its lifetime. Its unique asexual lifecycle consists of four stages: vegetative, aggregation, migration, and culmination. The lifecycle of ''D. discoideum'' is relatively short, which allows for timely viewing of all stages. The cells involved in the lifecycle undergo movement, chemical signaling, and development, which are applicable to human cancer research. The simplicity of its lifecycle makes ''D. discoideum'' a valuable model organism to study genetic, cellular, and biochemical processes in other organisms. Natural habitat and diet In the wild, ''D. discoideum'' can be found in soil and moist leaf litter. Its primary diet consists of bacteria, such as ''Escherichia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dicty Signal Relay
''Dictyostelium discoideum'' is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. Commonly referred to as slime mold, ''D. discoideum'' is a eukaryote that transitions from a collection of unicellular amoebae into a multicellular slug and then into a fruiting body within its lifetime. Its unique asexual lifecycle consists of four stages: vegetative, aggregation, migration, and culmination. The lifecycle of ''D. discoideum'' is relatively short, which allows for timely viewing of all stages. The cells involved in the lifecycle undergo movement, chemical signaling, and development, which are applicable to human cancer research. The simplicity of its lifecycle makes ''D. discoideum'' a valuable model organism to study genetic, cellular, and biochemical processes in other organisms. Natural habitat and diet In the wild, ''D. discoideum'' can be found in soil and moist leaf litter. Its primary diet consists of bacteria, such as ''Escherichia c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dicty Life Cycle H01
''Dictyostelium discoideum'' is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. Commonly referred to as slime mold, ''D. discoideum'' is a eukaryote that transitions from a collection of unicellular amoebae into a multicellular slug and then into a fruiting body within its lifetime. Its unique asexual lifecycle consists of four stages: vegetative, aggregation, migration, and culmination. The lifecycle of ''D. discoideum'' is relatively short, which allows for timely viewing of all stages. The cells involved in the lifecycle undergo movement, chemical signaling, and development, which are applicable to human cancer research. The simplicity of its lifecycle makes ''D. discoideum'' a valuable model organism to study genetic, cellular, and biochemical processes in other organisms. Natural habitat and diet In the wild, ''D. discoideum'' can be found in soil and moist leaf litter. Its primary diet consists of bacteria, such as ''Escherichia c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dictyostelium Purpureum
''Dictyostelium purpureum'' is a species of ''Dictyostelium''. ''Dictyostelium purpureum'' is a distinct species from ''D. discoideum'', although it belongs in the same phenotypic grouping. Like ''D. discoideum'', it exhibits a robust multicellular life cycle, and shares some of the early signaling molecules with ''D. discoideum''. Both species spend vegetative growth preying on bacteria in the soil, and when starved, aggregate to enter multicellular development that culminates into a fruiting body with resistant viable spores (''D. purpureum'' is so named for its strikingly purple spores), and supporting stalk structures. Altruism Wild strains of ''D. purpureum'' were taken from the Houston Arboretum to a lab where they were cultured in dishes. In each of 14 experiments, a pair of strains were placed in a dish in equal proportion, and one of the strains in each pair was labeled with a fluorescent dye. Food was withheld, causing the microbes in each dish to form dozens of slugs a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phospholipase
A phospholipase is an enzyme that hydrolyzes phospholipids into fatty acids and other lipophilic substances. Acids trigger the release of bound calcium from cellular stores and the consequent increase in free cytosolic Ca2+, an essential step in calcium signaling to regulate intracellular processes. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze: *Phospholipase A **Phospholipase A1 – cleaves the ''sn''-1 acyl chain (where ''sn'' refers to stereospecific numbering). **Phospholipase A2 – cleaves the ''sn''-2 acyl chain, releasing arachidonic acid. * Phospholipase B – cleaves both ''sn''-1 and ''sn''-2 acyl chains; this enzyme is also known as a lysophospholipase. *Phospholipase C – cleaves before the phosphate, releasing diacylglycerol and a phosphate-containing head group. PLCs play a central role in signal transduction, releasing the second messenger inositol triphosphate. * Phospholipase D †... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adenylate Cyclase
Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: :ATP = 3′,5′-cyclic AMP + diphosphate It has key regulatory roles in essentially all cells. It is the most polyphyletic known enzyme: six distinct classes have been described, all catalyzing the same reaction but representing unrelated gene families with no known sequence or structural homology. The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). AC-III occurs widely in eukaryotes and has important roles in many human tissues. All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate.Magnesium ions are generally required and appear to be closely involved in the enzymatic mechanism. The cAMP produced by AC t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G-protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their activity is regulated by factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to the larger group of enzymes called GTPases. There are two classes of G proteins. The first function as monomeric small GTPases (small G-proteins), while the second function as heterotrimeric G protein complexes. The latter class of complexes is made up of ''alpha'' (α), ''beta'' (β) and ''gamma'' (γ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex . Heterotrimeric G proteins located within the cell are activa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Adenosine Monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. History Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). Synthesis Cyclic adenosine monophosphate, AMP is synthesized from Adenosine triphosphate, ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. Adenylate cyclase is ''activated'' by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs alpha subunit, Gs)-protein-coupled recep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DictyBase
dictyBase is an online bioinformatics database for the model organism ''Dictyostelium discoideum ''Dictyostelium discoideum'' is a species of soil-dwelling amoeba belonging to the phylum Amoebozoa, infraphylum Mycetozoa. Commonly referred to as slime mold, ''D. discoideum'' is a eukaryote that transitions from a collection of unicellular ...''. Tools dictyBase offers many ways of searching and retrieving data from the database: * dictyMart - a tool for retrieving varied information on many genes (or the sequences of those genes). * Genome Browser - browse the genes of ''D. discoideum'' in their genomic context. References External links dictyBase Developmental biology Model organism databases Mycetozoa {{Database-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Programmed Cell Death
Programmed cell death (PCD; sometimes referred to as cellular suicide) is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. PCD is carried out in a biological process, which usually confers advantage during an organism's lifecycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. PCD serves fundamental functions during both plant and animal tissue development. Apoptosis and autophagy are both forms of programmed cell death. Necrosis is the death of a cell caused by external factors such as trauma or infection and occurs in several different forms. Necrosis was long seen as a non-physiological process that occurs as a result of infection or injury, but in the 2000s, a form of programmed necrosis, called necroptosis, was recognized as an alternative form of programmed cell death. It is hypothesized that necroptosis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
