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Desmosterol
Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. 24-dehydrocholesterol reductase catalyses the reduction of desmosterol to cholesterol. It is accumulated in desmosterolosis. In 2014, it was named the Molecule of the Year 2012 by the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR). See also * Triparanol Triparanol (, ; brand name and development code MER/29, as well as many other brand names) was the first synthetic cholesterol-lowering drug. It was patented in 1959 and introduced in the United States in 1960. The developmental code name of trip ... References Cholestanes {{steroid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desmosterolosis
Desmosterolosis in medicine and biology is a defect in cholesterol biosynthesis. It results in an accumulation of desmosterol and a variety of associated symptom Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showin ...s. Only two cases have been reported as of 2007. The condition is due to inactivating mutations in 24-dehydrocholesterol reductase. Certain anticholesterolemic and antiestrogenic drugs such as triparanol, ethamoxytriphetol, and clomifene have been found to inhibit conversion of desmosterol into cholesterol and to induce desmosterolosis, for instance cataracts. References External links Cholesterol and steroid metabolism disorders {{Endocrine-disease-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triparanol
Triparanol (, ; brand name and development code MER/29, as well as many other brand names) was the first synthetic cholesterol-lowering drug. It was patented in 1959 and introduced in the United States in 1960. The developmental code name of triparanol, MER/29, became so well known that it became the registered trade name of the drug. It was withdrawn in 1962 due to severe adverse effects such as nausea and vomiting, vision loss due to irreversible cataracts, alopecia, skin disorders (e.g., dryness, itching, peeling, and "fish-scale" texture), and accelerated atherosclerosis. It is now considered to be obsolete. The drug acts by inhibiting 24-dehydrocholesterol reductase, which catalyzes the final step of cholesterol biosynthesis, the conversion of desmosterol into cholesterol. Although effective in reducing cholesterol levels, this results in tissue accumulation of desmosterol, which in turn is responsible for the side effects of triparanol. Unlike statins, triparanol does no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholesterol
Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membranes. When chemically isolated, it is a yellowish crystalline solid. Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as '' Mycoplasma'', which require cholesterol for growth. François Poulletier de la Salle first identified cholesterol in solid form in gallstones in 1769. However, it was not until 1815 that chemist Michel Eugène Chevreul named the compound "cholesterine". Etymology The word "cholesterol" comes from the Ancient Greek ''chole-'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecule Of The Year
The Breakthrough of the Year is an annual award for the most significant development in scientific research made by the AAAS journal '' Science,'' an academic journal covering all branches of science. Originating in 1989 as the ''Molecule of the Year'', and inspired by '' Time'' Man of the Year, it was renamed the Breakthrough of the Year in 1996. Molecule of the Year * 1989 PCR and DNA polymerase * 1990 the manufacture of synthetic diamonds * 1991 buckminsterfullerene * 1992 nitric oxide * 1993 p53 * 1994 DNA repair enzyme Breakthrough of the Year * 1996: Understanding HIV * 1997: Dolly the sheep, the first mammal to be cloned from adult cells * 1998: Accelerating universe * 1999: Prospective stem-cell therapies * 2000: Full genome sequencing * 2001: Nanocircuits or Molecular circuit * 2002: RNA interference * 2003: Dark energy * 2004: ''Spirit'' rover landed on Mars * 2005: Evolution in action * 2006: Proof of the Poincaré conjecture * 2007: Human geneti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ISMCBBPR
The Breakthrough of the Year is an annual award for the most significant development in scientific research made by the AAAS journal '' Science,'' an academic journal covering all branches of science. Originating in 1989 as the ''Molecule of the Year'', and inspired by '' Time'' Man of the Year, it was renamed the Breakthrough of the Year in 1996. Molecule of the Year * 1989 PCR and DNA polymerase * 1990 the manufacture of synthetic diamonds * 1991 buckminsterfullerene * 1992 nitric oxide * 1993 p53 * 1994 DNA repair enzyme Breakthrough of the Year * 1996: Understanding HIV * 1997: Dolly the sheep, the first mammal to be cloned from adult cells * 1998: Accelerating universe * 1999: Prospective stem-cell therapies * 2000: Full genome sequencing * 2001: Nanocircuits or Molecular circuit * 2002: RNA interference * 2003: Dark energy * 2004: ''Spirit'' rover landed on Mars * 2005: Evolution in action * 2006: Proof of the Poincaré conjecture * 2007: Human genetic v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
