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Dennis Patrick Curran
Dennis P. Curran (born June 10, 1953) is an American organic chemist and a professor of chemistry at University of Pittsburgh known for his research in the fields of organic chemistry, radical chemistry, and fluorous chemistry. Career and personal life Curran received his BS degree from Boston College in 1975 and his PhD degree from the University of Rochester in 1979 working under the direction of Andrew S. Kende. After postdoctoral studies with Barry Trost at the University of Wisconsin, he joined the University of Pittsburgh Department of Chemistry as an Assistant Professor in 1981. He became Associate Professor in 1986, Full Professor in 1988, and Distinguished Service Professor in 1995. He became the first Bayer Professor of Chemistry in 1996 and since 2019 is the Covestro Professor of Chemistry. Chemistry runs in Curran's family. His father, Dr. William V. Curran (1929-2019), was a 60-year member of the American Chemical Society and the inventor of the third-generatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Easton, Pennsylvania
Easton is a city in, and the county seat of, Northampton County, Pennsylvania, United States. The city's population was 28,127 as of the 2020 United States census, 2020 census. Easton is located at the confluence of the Lehigh River, a river that joins the Delaware River in Easton and serves as the city's eastern geographic boundary with Phillipsburg, New Jersey. Easton is the easternmost city in the Lehigh Valley, a region of that is Pennsylvania's third largest Metropolitan statistical area, metropolitan region with 861,889 residents as of the 2020 United States census, U.S. 2020 census. Of the Valley's three major cities, Allentown, Pennsylvania, Allentown, Bethlehem, Pennsylvania, Bethlehem, and Easton, Easton is the smallest with approximately one-fourth the population of Allentown, the Valley's largest city. The greater Easton area includes the city of Easton, three townships (Forks Township, Northampton County, Pennsylvania, Forks, Palmer Township, Northampton County, Pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radical Cyclization
Radical cyclization reactions are organic chemical transformations that yield cyclic products through radical intermediates. They usually proceed in three basic steps: selective radical generation, radical cyclization, and conversion of the cyclized radical to product. Introduction Radical cyclization reactions produce mono- or polycyclic products through the action of radical intermediates. Because they are intramolecular transformations, they are often very rapid and selective. Selective radical generation can be achieved at carbons bound to a variety of functional groups, and reagents used to effect radical generation are numerous. The radical cyclization step usually involves the attack of a radical on a multiple bond. After this step occurs, the resulting cyclized radicals are quenched through the action of a radical scavenger, a fragmentation process, or an electron-transfer reaction. Five- and six-membered rings are the most common products; formation of smaller and larger ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Chemists
The 1st century was the century spanning AD 1 ( I) through AD 100 ( C) according to the Julian calendar. It is often written as the or to distinguish it from the 1st century BC (or BCE) which preceded it. The 1st century is considered part of the Classical era, epoch, or historical period. The 1st century also saw the appearance of Christianity. During this period, Europe, North Africa and the Near East fell under increasing domination by the Roman Empire, which continued expanding, most notably conquering Britain under the emperor Claudius ( AD 43). The reforms introduced by Augustus during his long reign stabilized the empire after the turmoil of the previous century's civil wars. Later in the century the Julio-Claudian dynasty, which had been founded by Augustus, came to an end with the suicide of Nero in AD 68. There followed the famous Year of Four Emperors, a brief period of civil war and instability, which was finally brought to an end by Vespasian, ninth Roman em ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1953 Births
Events January * January 6 – The Asian Socialist Conference opens in Rangoon, Burma. * January 12 – Estonian émigrés found a government-in-exile in Oslo. * January 14 ** Marshal Josip Broz Tito is chosen President of Yugoslavia. ** The CIA-sponsored Robertson Panel first meets to discuss the UFO phenomenon. * January 15 – Georg Dertinger, foreign minister of East Germany, is arrested for spying. * January 19 – 71.1% of all television sets in the United States are tuned into ''I Love Lucy'', to watch Lucy give birth to Little Ricky, which is more people than those who tune into Dwight Eisenhower's inauguration the next day. This record has yet to be broken. * January 20 – Dwight D. Eisenhower is sworn in as the 34th President of the United States. * January 24 ** Mau Mau Uprising: Rebels in Kenya kill the Ruck family (father, mother, and six-year-old son). ** Leader of East Germany Walter Ulbricht announces that agriculture will be col ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Université Pierre Et Marie Curie
Pierre and Marie Curie University (french: link=no, Université Pierre-et-Marie-Curie, UPMC), also known as Paris 6, was a public research university in Paris, France, from 1971 to 2017. The university was located on the Jussieu Campus in the Latin Quarter of the 5th arrondissement of Paris, France. UPMC merged with Paris-Sorbonne University into a new combined Sorbonne University. It was ranked as the best university in France in medicine and health sciences by ''Times Higher Education'' in 2018. History Paris VI was one of the inheritors of the faculty of Sciences of the University of Paris, which was divided into several universities in 1970 after the student protests of May 1968. In 1971, the five faculties of the former University of Paris (Paris VI as the Faculty of Sciences) were split and then re-formed into thirteen universities by the Faure Law. The campus of Paris VI was built in the 1950s and 1960s, on a site previously occupied by wine storehouses. The Dean, Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blaise Pascal Chair
The Blaise Pascal Chairs (Chaires Internationales de Recherché Blaise Pascal), established in 1996 by the Government of the Île-de-France Region for internationally acclaimed foreign scientists in all disciplines. A scientific committee annually selects the most outstanding candidates from all over the world. Since their inception a number of famous scientists have been Blaise Pascal Chair laureates: Gérard Debreu (UC Berkeley, 1983 Nobel Prize in Economics), Ahmed Zewail (Caltech, 1999 Nobel Prize in Chemistry), Igor Mel'čuk (University of Montreal, the world leading researcher in linguistics), George Smoot (LBL, 2006 Nobel Prize in experimental Astrophysics), Robert Langlands (UBC, 1996 Wolf Prize, one of the most influential mathematicians of the 20th century), outstanding theoretical physicists Gabriele Veneziano (CERN/College de France), Alexander Zamolodchikov Alexander Borisovich Zamolodchikov (russian: Алекса́ндр Бори́сович Замоло́дчико ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moses Gomberg
Moses Gomberg (February 8, 1866 – February 12, 1947) was a chemistry professor at the University of Michigan. He was elected to the National Academy of Sciences and served as president of the American Chemical Society. Early life and education He was born in Yelisavetgrad, Russian Empire to a Jewish merchant family. His father was Hershko (Hirsh) Gomberg and his mother was Maryam-Ethel Reznikova. In 1884, the family emigrated to Chicago to escape the pogroms following the assassination of Czar Alexander II. In Chicago he worked at the Stock Yards while attending Lake High School. In 1886, Moses entered the University of Michigan, where he obtained his B.Sc. in 1890 and his doctorate in 1894 under the supervision of A. B. Prescott. His thesis, titled "''Trimethylxanthine and Some of its Derivatives''", dealt with the derivatization of caffeine. Career Appointed an instructor in 1893, Gomberg worked at the University of Michigan for the duration of his professional academic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Syntheses
''Organic Syntheses'' is a peer-reviewed scientific journal that was established in 1921. It publishes detailed and checked procedures for the synthesis of organic compounds. A unique feature of the review process is that all of the data and experiments reported in an article must be successfully repeated in the laboratory of a member of the editorial board as a check for reproducibility prior to publication. The journal is published by Organic Syntheses, Inc., a non-profit corporation. An annual print version is published by John Wiley & Sons on behalf of Organic Syntheses, Inc. History Prior to World War I, work on synthetic organic chemistry in the United States had been quite limited, and most of the reagents used in laboratories had to be imported from Europe. When export stoppages and trade embargoes cut off this source, Clarence Derick, a professor of chemistry at University of Illinois at Urbana-Champaign, began an effort to synthesize these needed chemicals in industr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of ''Camptotheca acuminata'' (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the treatment of gastrointestinal tumors. CPT showed anticancer activity in preliminary clinical trials, especially against breast, ovarian, colon, lung, and stomach cancers. However, it has low solubility and adverse effects have been reported when used therapeutically, so synthetic and medicinal chemists have developed numerous syntheses of camptothecin and various derivatives to increase the benefits of the chemical, with good results. Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atom Economy
Atom economy (atom efficiency/percentage) is the conversion efficiency of a chemical process in terms of all atoms involved and the desired products produced. The simplest definition was introduced by Barry Trost in 1991 and is equal to the ratio between the mass of desired product to the total mass of products, expressed as a percentage. The concept of atom economy (AE) and the idea of making it a primary criterion for improvement in chemistry, is a part of the green chemistry movement that was championed by Paul Anastas from the early 1990s. Atom economy is an important concept of green chemistry philosophy, and one of the most widely used metrics for measuring the "greenness" of a process or synthesis. Good atom economy means most of the atoms of the reactants are incorporated in the desired products and only small amounts of unwanted byproducts are formed, reducing the economic and environmental impact of waste disposal. Atom economy can be written as: :\text = \frac \tim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morris S
Morris may refer to: Places Australia *St Morris, South Australia, place in South Australia Canada * Morris Township, Ontario, now part of the municipality of Morris-Turnberry * Rural Municipality of Morris, Manitoba ** Morris, Manitoba, a town mostly surrounded by the municipality * Morris (electoral district), Manitoba (defunct) * Rural Municipality of Morris No. 312, Saskatchewan United States ;Communities * Morris, Alabama, a town * Morris, Connecticut, a town * Morris, Georgia, an unincorporated community * Morris, Illinois, a city * Morris, Indiana, an unincorporated community * Morris, Minnesota, a city * Morristown, New Jersey, a town * Morris (town), New York ** Morris (village), New York * Morris, Oklahoma, a city * Morris, Pennsylvania, an unincorporated community * Morris, West Virginia, an unincorporated community * Morris, Kanawha County, West Virginia, a ghost town * Morris, Wisconsin, a town * Morris Township (other) ;Counties and other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kharasch Addition
The Kharasch addition is an organic reaction and a metal-catalysed free radical addition of CXCl3 compounds (X = Cl, Br, H) to alkenes. The reaction is used to append trichloromethyl or dichloromethyl groups to terminal alkenes. The method has attracted considerable interest, but it is of limited value because of narrow substrate scope and demanding conditions. The basic reaction proceeds through the CXCl2 free radical. Examples of organohalides are carbon tetrachloride and chloroform. Radicals are often generated by abstraction of a halide radical my a metal ion. The addition is an anti-Markovnikov addition In organic chemistry, Markovnikov's rule or Markownikoff's rule describes the outcome of some addition reactions. The rule was formulated by Russian chemist Vladimir Markovnikov in 1870. Explanation The rule states that with the addition of a .... Early work linked the addition to olefin polymerization and is therefore considered a first step into what was to becom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
