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Dennis Drayna
Dennis T. Drayna (born 1952) is an American human geneticist known for his contributions to stuttering, human haemochromatosis, pitch, and taste. He is currently the Section Chief of Genetics of Communication Disorders at the U.S. National Institute for Deafness and Other Communication Disorders. Biography Drayna graduated from the University of Wisconsin in 1976, and obtained a Ph.D. from Harvard University in 1981. He performed his post-doctoral training at the Howard Hughes Medical Institute in the lab of Raymond White, where he created the first full length genetic linkage map of the human X chromosome. After completing his post-doctoral training, Drayna joined the scientific staff of Genentech in 1985, where, most notably, he cloned and sequenced cholesteryl ester transfer protein among other contributions. In 1992, Drayna left Genentech to co-found Mercator Genetics, a bio-technology company focused on commercializing human genomic discoveries. Here, Drayna discovered ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stuttering
Stuttering, also known as stammering, is a speech disorder in which the flow of speech is disrupted by involuntary repetitions and prolongations of sounds, syllables, words, or phrases as well as involuntary silent pauses or blocks in which the person who stutters is unable to produce sounds. The term ''stuttering'' is most commonly associated with involuntary sound repetition, but it also encompasses the abnormal hesitation or pausing before speech, referred to by people who stutter as ''blocks'', and the prolongation of certain sounds, usually vowels or semivowels. According to Watkins et al., stuttering is a disorder of "selection, initiation, and execution of motor sequences necessary for fluent speech production". arlson, N. (2013). Human Communication. In Physiology of behavior (11th ed., pp. 497–500). Boston: Allyn and Bacon./ref> For many people who stutter, repetition is the main concern. The term "stuttering" covers a wide range of severity, from barely perceptible imp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenylthiocarbamide
Phenylthiocarbamide (PTC), also known as phenylthiourea (PTU), is an organosulfur thiourea containing a phenyl ring. It has the unusual property that it either tastes very bitter or is virtually tasteless, depending on the genetic makeup of the taster. The ability to taste PTC is often treated as a dominant genetic trait, although inheritance and expression of this trait are somewhat more complex. PTC also inhibits melanogenesis and is used to grow transparent fish. About 70% of people can taste PTC, varying from a low of 58% for Indigenous Australians and indigenous peoples of New Guinea to 98% for indigenous peoples of the Americas. One study has found that non-smokers and those not habituated to coffee or tea have a statistically higher percentage of tasting PTC than the general population. PTC does not occur in food, but related chemicals do, and food choice is related to a person's ability to taste PTC. History The tested genetic taste phenomenon of PTC was discovere ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1952 Births
Year 195 ( CXCV) was a common year starting on Wednesday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Scrapula and Clemens (or, less frequently, year 948 ''Ab urbe condita''). The denomination 195 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * Emperor Septimius Severus has the Roman Senate deify the previous emperor Commodus, in an attempt to gain favor with the family of Marcus Aurelius. * King Vologases V and other eastern princes support the claims of Pescennius Niger. The Roman province of Mesopotamia rises in revolt with Parthian support. Severus marches to Mesopotamia to battle the Parthians. * The Roman province of Syria is divided and the role of Antioch is diminished. The Romans annexed the Syrian cities of Edessa and Nisibis. Severus re-establish his h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University Alumni
The list of Harvard University people includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see notable non-graduate alumni of Harvard. For a list of Harvard's presidents, see President of Harvard University. Eight President of the United States, Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Wisconsin–Madison Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Maryland, College Park
The University of Maryland, College Park (University of Maryland, UMD, or simply Maryland) is a public land-grant research university in College Park, Maryland. Founded in 1856, UMD is the flagship institution of the University System of Maryland. It is also the largest university in both the state and the Washington metropolitan area, with more than 41,000 students representing all fifty states and 123 countries, and a global alumni network of over 388,000. Together, its 12 schools and colleges offer over 200 degree-granting programs, including 92 undergraduate majors, 107 master's programs, and 83 doctoral programs. UMD is a member of the Association of American Universities and competes in intercollegiate athletics as a member of the Big Ten Conference. The University of Maryland's proximity to the nation's capital has resulted in many research partnerships with the federal government; faculty receive research funding and institutional support from many agencies, such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stuttering Foundation Of America
The Stuttering Foundation of America provides free online resources, services and support to those who stutter and their families, as well as support for research into the causes of stuttering. A 501(c)(3) nonprofit organization, The Stuttering Foundation was established by Malcolm Fraser, the co-founder of Genuine Parts Company, in 1947 in Memphis, Tennessee. The Stuttering Foundation provides a toll-free helpline, free printed and online resources including books, pamphlets, videos, posters, referral services, support and information for people who stutter and their families, and research into the causes of stuttering. Today, Malcolm Fraser's daughter, Jane Fraser, is president of the Foundation. In 2007, Fraser was named the Nonprofit Executive of the Year by ''The NonProfit Times''. The Foundation sponsors educational conferences, workshops and symposia, and week-long intensive training workshops for speech-language pathologists. History In 1947, Malcolm Fraser, a young man ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Menthol Cigarette
A menthol cigarette is a cigarette flavored with the compound menthol. Menthol cigarettes have been banned in several countries, including Brazil, Canada, Ethiopia, Turkey, Moldova, the European Union, the United Kingdom and the US states of Massachusetts and California, even though experts note that menthols are not harder to quit and are not more harmful than regular cigarettes. Some countries still allow menthol and capsule filter tips that are sold separately. Origins and history Menthol cigarettes were first developed by Lloyd "Spud" Hughes of Mingo Junction, Ohio, in 1924, though the idea did not become popular until the Axton-Fisher Tobacco Co. acquired the patent in 1927, marketing them nationwide as "Spud Menthol Cooled Cigarettes". Spud brand menthol cigarettes went on to become the fifth most popular brand in the US by 1932, and it remained the only menthol cigarette on the market until the Brown & Williamson Tobacco Company created the Kool brand in 1933. For ove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HFE Hereditary Haemochromatosis
Hereditary haemochromatosis type 1 (HFE-related Hemochromatosis) is a genetic disorder characterized by excessive intestinal absorption of dietary iron, resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron, with the exception of menstruation which, for the average woman, results in a loss of 3.2 mg of iron. Excess iron accumulates in tissues and organs, disrupting their normal function. The most susceptible organs include the liver, heart, pancreas, skin, joints, gonads, thyroid and pituitary gland; patients can present with cirrhosis, polyarthropathy, hypogonadism, heart failure, or diabetes.https://www.cdc.gov/genomics/disease/hemochromatosis.htm. Centers for Disease Control and Prevention There are 5 types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 and 5, all caused by mutated genes. Hereditary hemochromatosis is the most frequent, and unique related to the HFE gene. It is most com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iron Overload
Iron overload or hemochromatosis (also spelled ''haemochromatosis'' in British English) indicates increased total accumulation of iron in the body from any cause and resulting organ damage. The most important causes are hereditary haemochromatosis (HH or HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions. Signs and symptoms Organs most commonly affected by hemochromatosis include the liver, heart, and endocrine glands. Hemochromatosis may present with the following clinical syndromes: * liver: chronic liver disease and cirrhosis of the liver. * heart: heart failure, cardiac arrhythmia. * hormones: diabetes (see below) and hypogonadism (insufficiency of the sex hormone producing glands) which leads to low sex drive and/or loss of fertility in men and loss of menstrual cycle in women. * metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in the pancreas lead ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholesterylester Transfer Protein
Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or Chylomicrons and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride. Genetics The ''CETP'' gene is located on the sixteenth chromosome (16q21). Protein Fold The crystal structure of CETP is that of dimer of two TUbular LIPid (TULIP) binding domains. Each domain consists of a core of 6 elements: 4 beta-sheets forming an extended superhelix; 2 flanking elements that tend to include some alpha helix. The sheets wrap around the helices to produce a cylinder 6 x 2.5 x 2.5 nm. CETP contains two of these domains that interact head-to-head v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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