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Demoxytocin
Demoxytocin (INN) (brand names Sandopart, Odeax, Sandopral), also known as desaminooxytocin or deaminooxytocin, as well as 1-(3-mercaptopropanoic acid)oxytocin ( Mpa1.html" ;"title="/nowiki>Mpa1">/nowiki>Mpa1/nowiki>OT), is an oxytocic peptide drug that is used to induce labor, promote lactation, and to prevent and treat puerperal (postpartum) mastitis (breast inflammation). Demoxytocin is a synthetic analogue of oxytocin and has similar activities, but is more potent and has a longer half-life in comparison. Unlike oxytocin, which is given via intravenous injection, demoxytocin is administered as a buccal tablet formulation. The drug was first synthesized in 1960 and was introduced into clinical practice in 1971 by Sandoz. It is marketed in several European countries, including Italy, Czech Republic, and Poland. It has the amino acid sequence Mpa-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Mpa = β-mercaptopropionic acid), and is an analogue of oxytocin wherein the leading cysteine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merotocin
Merotocin (INN) (developmental code name FE-202767), also known as carba-1-(4-FBzlGly7)dOT, is a peptidic agonist of the oxytocin receptor that was derived from oxytocin. It is under development by Ferring Pharmaceuticals for the treatment of preterm mothers with lactation failure requiring lactation support, and is in phase II clinical trials for this indication. Merotocin is potent ( EC50 1000-fold over the related vasopressin receptors). See also * Carbetocin * Demoxytocin Demoxytocin ( INN) (brand names Sandopart, Odeax, Sandopral), also known as desaminooxytocin or deaminooxytocin, as well as 1-(3-mercaptopropanoic acid)oxytocin ( Mpa1.html" ;"title="/nowiki>Mpa1">/nowiki>Mpa1/nowiki>OT), is an oxytocic peptide dr ... * TC OT 39 * WAY-267,464 References External links Pipeline - Ferring PharmaceuticalsMerotocin - AdisInsight Oxytocin receptor agonists Cyclic peptides {{drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |