Decade Of The Brain
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Decade Of The Brain
The Decade of the Brain was a designation for 1990–1999 by U.S. president George H. W. Bush as part of a larger effort involving the Library of Congress and the National Institute of Mental Health of the National Institutes of Health "to enhance public awareness of the benefits to be derived from brain research". The interagency initiative was conducted through a variety of activities including publications and programs aimed at introducing members of Congress, their staffs, and the general public to cutting-edge research on the human brain and encouraging public dialog on the ethical, philosophical, and humanistic implications of these discoveries. Inception During the 1980s, a renewed interest in the localization of neural phenomena to distinct anatomical regions of the brain led to a rapid uptick in more direct study of the brain and its psychological implications. In 1980, the Society for Neuroscience founded a committee dedicated to lobbying directly with the United Sta ...
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Decade Of The Brain
The Decade of the Brain was a designation for 1990–1999 by U.S. president George H. W. Bush as part of a larger effort involving the Library of Congress and the National Institute of Mental Health of the National Institutes of Health "to enhance public awareness of the benefits to be derived from brain research". The interagency initiative was conducted through a variety of activities including publications and programs aimed at introducing members of Congress, their staffs, and the general public to cutting-edge research on the human brain and encouraging public dialog on the ethical, philosophical, and humanistic implications of these discoveries. Inception During the 1980s, a renewed interest in the localization of neural phenomena to distinct anatomical regions of the brain led to a rapid uptick in more direct study of the brain and its psychological implications. In 1980, the Society for Neuroscience founded a committee dedicated to lobbying directly with the United Sta ...
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RIKEN Brain Science Institute
RIKEN Brain Science Institute (RIKEN-BSI) was established in 1997 as part of RIKEN, focusing on neuroscience research located in Wakō city, Saitama Prefecture in the greater Tokyo area, Japan. In 2018 RIKEN-BSI has been reorganized as RIKEN Center for Brain Science, a new center under RIKEN. Yasushi Miyashita became the first Director of RIKEN-CBS.The current director is Ryoichiro Kageyama (2021-). Overview of RIKEN-BSI Masao Ito, formerly a professor at the Faculty of Medicine of Tokyo University, joined RIKEN as the second director of the (former) International Frontier System and initiated the neuroscience research in RIKEN in 1989 after his retirement. It was first major move towards biological science in RIKEN, which had been dominated by physics and chemistry. In 1997, it was expanded to become BSI and Ito became the first director. Subsequently, it was led by the second director, Shun'ichi Amari and interim director Keiji Tanaka, and then currently by 1987 Nobel lau ...
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Brain Mapping
Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties onto spatial representations of the (human or non-human) brain resulting in maps. According to the definition established in 2013 by Society for Brain Mapping and Therapeutics (SBMT), brain mapping is specifically defined, in summary, as the study of the anatomy and function of the brain and spinal cord through the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology. Overview All neuroimaging is considered part of brain mapping. Brain mapping can be conceived as a higher form of neuroimaging, producing brain images supplemented by the result of additional (imaging or non-imaging) data processing or analysis, such as maps projecting (measures of) behavior onto brain regions (see fMRI). One such map, called a connectogram, depicts cortical regions around a circle, org ...
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BRAIN Initiative
The White House BRAIN Initiative (Brain Research through Advancing Innovative Neurotechnologies) is a collaborative, public-private research initiative announced by the Obama administration on April 2, 2013, with the goal of supporting the development and application of innovative technologies that can create a dynamic understanding of brain function. This activity is a Grand Challenge focused on revolutionizing our understanding of the human brain, and was developed by the White House Office of Science and Technology Policy (OSTP) as part of a broader White House Neuroscience Initiative. Inspired by the Human Genome Project, BRAIN aims to help researchers uncover the mysteries of brain disorders, such as Alzheimer's and Parkinson's diseases, depression, and traumatic brain injury (TBI). Participants in BRAIN and affiliates of the project include DARPA and IARPA as well as numerous private companies, universities, and other organizations in the United States, Australia, Canada, ...
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Decade Of The Mind
The Decade of the Mind Project is an international initiative to advance scientific understanding of how the mind and complex behaviors are related to the activity of human brains. The problem of explaining the mind is so complex as to require "big science" to make real progress. The effort stemmed from concerns in the scientific community that mind research (as opposed to simply brain research) had received inadequate support relative to its importance in human lives. The Project began with a conference of leading US scientists at George Mason University in May 2007 which led to The Decade of the Mind Manifesto, published as a letter to the editor in ''Science''. The Manifesto called for a new $4B US investment in research across the many disciplines of mind research over the decade from 2012 to 2022. Since the May 2007 meeting, the Decade of the Mind Project has held several other conferences across the United States and has been internationalised with a conference in Berlin, G ...
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Alcoholism
Alcoholism is, broadly, any drinking of alcohol (drug), alcohol that results in significant Mental health, mental or physical health problems. Because there is disagreement on the definition of the word ''alcoholism'', it is not a recognized diagnostic entity. Predominant diagnostic classifications are alcohol use disorder (DSM-5) or alcohol dependence (ICD-11); these are defined in their respective sources. Excessive alcohol use can damage all organ systems, but it particularly affects the brain, heart, liver, pancreas and immune system. Alcoholism can result in mental illness, delirium tremens, Wernicke–Korsakoff syndrome, Heart arrhythmia, irregular heartbeat, an impaired immune response, liver cirrhosis and alcohol and cancer, increased cancer risk. Drinking during pregnancy can result in fetal alcohol spectrum disorders. Women are generally more sensitive than men to the harmful effects of alcohol, primarily due to their smaller body weight, lower capacity to metaboli ...
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Rett Syndrome
Rett syndrome (RTT) is a genetic disorder that typically becomes apparent after 6–18 months of age and almost exclusively in females. Symptoms include impairments in language and coordination, and repetitive movements. Those affected often have slower growth, difficulty walking, and a smaller head size. Complications of Rett syndrome can include seizures, scoliosis, and sleeping problems. The severity of the condition is variable. Rett syndrome is due to a genetic mutation in the MECP2 gene, on the X chromosome. It almost always occurs as a new mutation, with less than one percent of cases being inherited from a person's parents. It occurs almost exclusively in girls; boys who have a similar mutation typically die shortly after birth. Diagnosis is based on the symptoms and can be confirmed with genetic testing. There is no known cure for Rett syndrome. Treatment is directed at improving symptoms. Anticonvulsants may be used to help with seizures. Special education, ph ...
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Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most common type of motor neuron diseases. Early symptoms of ALS include stiff muscles, muscle twitches, and gradual increasing weakness and muscle wasting. ''Limb-onset ALS'' begins with weakness in the arms or legs, while ''bulbar-onset ALS'' begins with difficulty speaking or swallowing. Half of the people with ALS develop at least mild difficulties with thinking and behavior, and about 15% develop frontotemporal dementia. Most people experience pain. The affected muscles are responsible for chewing food, speaking, and walking. Motor neuron loss continues until the ability to eat, speak, move, and finally the ability to breathe is lost. ALS eventually causes paralysis and early death, usually from respiratory failure. Most cases of ALS (a ...
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Huntington's Disease
Huntington's disease (HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea. As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. Mental abilities generally decline into dementia. The specific symptoms vary somewhat between people. Symptoms usually begin between 30 and 50 years of age but can start at any age. The disease may develop earlier in each successive generation. About eight percent of cases start before the age of 20 years, and are known as ''juvenile HD'', which typically present with the slow movement symptoms of Parkinson's d ...
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Antipsychotic
Antipsychotics, also known as neuroleptics, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay together with mood stabilizers in the treatment of bipolar disorder. Prior research has shown that use of any antipsychotic is associated with smaller brain tissue volumes, including white matter reduction and that this brain shrinkage is dose dependent and time dependent. A more recent controlled trial suggests that second generation antipsychotics combined with intensive psychosocial therapy may potentially prevent pallidal brain volume loss in first episode psychosis. The use of antipsychotics may result in many unwanted side effects such as Extrapyramidal symptoms, involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. ...
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Antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, headaches, sexual dysfunction, and emotional blunting. There is a slight increased risk of suicidal thinking and behavior when taken by children, adolescents, and young adults. Discontinuation syndrome may occur after stopping any antidepressant which resembles recurrent depression. Some research regarding the effectiveness of antidepressants for depression in adults has found benefits, whilst other research has not. Evidence of benefit in children and adolescents is unclear. The twenty-one most commonly prescribed antidepressant medications are more effective than placebo for the short-term (acute) treatments of adults with major depressive disorder. There is debate in the medical community about how much of the observed effects of antidep ...
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Neural Development
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals. Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders including limb paresis and paralysis, balance and vision disorders, and seizures, and in humans other disorders such as Rett syndrome, Down syndrome and intellectual disability. Overview of vertebrate brain development The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes speci ...
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