Credé's Prophylaxis
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Credé's Prophylaxis
Credé procedure is the practice of washing a newborn's eyes with a 2% silver nitrate solution to protect against neonatal conjunctivitis caused by ''Neisseria gonorrhoeae''. The Credé procedure was developed by the German physician Carl Siegmund Franz Credé who implemented it in his hospital in Leipzig in 1880. Between 1881 and 1883, Credé published three papers in '' Archiv für Gynäkologie'', each titled "Die Verhütung der Augenentzündung der Neugeborenen" (Prevention of inflammatory eye disease in the newborn), describing his method and its results. The original procedure called for a 2% silver nitrate solution administered immediately after birth; however, this was eventually reduced to a 1% silver nitrate solution to reduce chemical irritation to the newborn's eyes. In the 1980s, silver nitrate was replaced by erythromycin and tetracycline Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used t ...
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Neonatal Conjunctivitis
Neonatal conjunctivitis is a form of conjunctivitis (inflammation of the outer eye) which affects newborn babies following birth. It is typically due to neonatal bacterial infection, although can also be non-infectious (e.g. chemical exposure). Infectious neonatal conjunctivitis is typically contracted during vaginal delivery from exposure to bacteria from the birth canal, most commonly ''Neisseria gonorrhoeae'' or ''Chlamydia trachomatis''. Antibiotic ointment is typically applied to the newborn's eyes within 1 hour of birth as prevention for gonococcal ophthalmia. This practice is recommended for all newborns and most hospitals in the United States are required by state law to apply eye drops or ointment soon after birth to prevent the disease. If left untreated, neonatal conjunctivitis can cause blindness. Signs and symptoms Neonatal conjunctivitis by definition presents during the first month of life. Signs and symptoms include: * Pain and tenderness in the eyeball * Conjunc ...
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Neisseria Gonorrhoeae
''Neisseria gonorrhoeae'', also known as ''gonococcus'' (singular), or ''gonococci'' (plural), is a species of Gram-negative diplococci bacteria isolated by Albert Ludwig Sigesmund Neisser, Albert Neisser in 1879. It causes the sexually transmitted infection, sexually transmitted genitourinary infection gonorrhea as well as other forms of gonococcal disease including disseminated gonococcemia, septic arthritis, and gonococcal ophthalmia neonatorum. It is oxidase test, oxidase positive and aerobic, and it survives phagocyte, phagocytosis and grows inside neutrophils. Microbiological culture, Culturing it requires carbon dioxide supplementation and enriched agar (chocolate agar) with various antibiotics (Thayer–Martin agar, Thayer–Martin). It exhibits antigenic variation through genetic recombination of its pilus, pili and surface proteins that interact with the immune system. Sexual transmission is through vaginal, anal, or oral sex. Sexual transmission may be prevented throu ...
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Carl Siegmund Franz Credé
Carl Siegmund Franz Credé (23 December 1819 – 14 March 1892) was a German gynecologist and obstetrician born in Berlin. In 1842 he received his doctorate from the University of Berlin. In 1852 he became director of the "Berlin School of Midwives" and chief physician of the maternity division at the Berlin Charité. Later he was appointed professor of obstetrics and director of the maternity hospital in Leipzig. In Berlin and Leipzig, Credé established out-patient gynecology clinics. He was the father of surgeon Benno Credé (1847–1929) and a father-in-law to gynecologist Christian Gerhard Leopold (1846–1912). Among his better known students at Leipzig was gynecologist Johann Friedrich Ahlfeld (1843–1929). Carl Credé is famous for introducing the use of silver nitrate eyedrops as an antiseptic for the prevention of ophthalmia neonatorum in newborns. He used a 2% silver nitrate solution, and first demonstrated its effectiveness in the early 1880s. During a three-y ...
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Leipzig
Leipzig ( , ; Upper Saxon: ) is the most populous city in the German state of Saxony. Leipzig's population of 605,407 inhabitants (1.1 million in the larger urban zone) as of 2021 places the city as Germany's eighth most populous, as well as the second most populous city in the area of the former East Germany after (East) Berlin. Together with Halle (Saale), the city forms the polycentric Leipzig-Halle Conurbation. Between the two cities (in Schkeuditz) lies Leipzig/Halle Airport. Leipzig is located about southwest of Berlin, in the southernmost part of the North German Plain (known as Leipzig Bay), at the confluence of the White Elster River (progression: ) and two of its tributaries: the Pleiße and the Parthe. The name of the city and those of many of its boroughs are of Slavic origin. Leipzig has been a trade city since at least the time of the Holy Roman Empire. The city sits at the intersection of the Via Regia and the Via Imperii, two important medieval trad ...
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Archiv Für Gynäkologie
Archiv Produktion is a classical music record label of German origin. It originated in 1949 as a classical label for the Deutsche Grammophon Gesellschaft (DGG), and in 1958 Archiv was established as a subsidiary of DGG, specialising in recordings of Early and Baroque music. It has since developed a particular focus on "historically informed performance" and the work of artists of the Early music revival movement of the 20th and 21st centuries. The first head of Archiv Produktion, serving in the position from 1948 to 1957, was Fred Hamel, a musicologist who set out the early Archiv Produktion releases according to 12 research periods, from Gregorian Chant to Mannheim and Vienna. Hamel's successor 1958-1968 Hans Hickmann was a professor at the University of Hamburg who focused on Bach and Handel. The next director was Andreas Holschneider (1931–2019) from 1970-1991. In December 1991 Holschneider gave an interview to ''Gramophone'' where he defended the entry of Archiv Produ ...
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Erythromycin
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. This includes respiratory tract infections, skin infections, chlamydia infections, pelvic inflammatory disease, and syphilis. It may also be used during pregnancy to prevent Group B streptococcal infection in the newborn, as well as to improve delayed stomach emptying. It can be given intravenously and by mouth. An eye ointment is routinely recommended after delivery to prevent eye infections in the newborn. Common side effects include abdominal cramps, vomiting, and diarrhea. More serious side effects may include ''Clostridium difficile'' colitis, liver problems, prolonged QT, and allergic reactions. It is generally safe in those who are allergic to penicillin. Erythromycin also appears to be safe to use during pregnancy. While generally regarded as safe during breastfeeding, its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in th ...
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Tetracycline
Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used to treat a number of infections, including Acne vulgaris, acne, cholera, brucellosis, plague (disease), plague, malaria, and syphilis. Common side effects include vomiting, diarrhea, rash, and loss of appetite. Other side effects include poor tooth development if used by children less than eight years of age, kidney problems, and sunburning easily. Use during pregnancy may harm the baby. It works by inhibiting protein synthesis in bacteria. Tetracycline was patented in 1953 and came into commercial use in 1978. It is on the World Health Organization's List of Essential Medicines. Tetracycline is available as a generic medication. Tetracycline was originally made from bacteria of the genus ''Streptomyces''. Medical uses Spectrum of activity Tetracyclines have a broad spectrum of antibiotic action. Originally, they possessed some level of bacteriostatic acti ...
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Chlamydia Trachomatis
''Chlamydia trachomatis'' (), commonly known as chlamydia, is a bacterium that causes chlamydia, which can manifest in various ways, including: trachoma, lymphogranuloma venereum, nongonococcal urethritis, cervicitis, salpingitis, pelvic inflammatory disease. ''C. trachomatis'' is the most common infectious cause of blindness and the most common sexually transmitted bacterium. Different types of ''C. trachomatis'' cause different diseases. The most common strains cause disease in the genital tract, while other strains cause disease in the eye or lymph nodes. Like other ''Chlamydia'' species, the ''C. trachomatis'' life cycle consists of two morphologically distinct life stages: elementary bodies and reticulate bodies. Elementary bodies are spore-like and infectious, whereas reticulate bodies are in the replicative stage and are seen only within host cells. Description ''Chlamydia trachomatis'' is a gram-negative bacterium that can replicate only within a host cell. Over the cour ...
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Obstetrical Procedures
Obstetrics is the field of study concentrated on pregnancy, childbirth and the postpartum period. As a medical specialty, obstetrics is combined with gynecology under the discipline known as obstetrics and gynecology (OB/GYN), which is a surgical field. Main areas Prenatal care Prenatal care is important in screening for various complications of pregnancy. This includes routine office visits with physical exams and routine lab tests along with telehealth care for women with low-risk pregnancies: Image:Ultrasound_image_of_a_fetus.jpg, 3D ultrasound of fetus (about 14 weeks gestational age) Image:Sucking his thumb and waving.jpg, Fetus at 17 weeks Image:3dultrasound 20 weeks.jpg, Fetus at 20 weeks First trimester Routine tests in the first trimester of pregnancy generally include: * Complete blood count * Blood type ** Rh-negative antenatal patients should receive RhoGAM at 28 weeks to prevent Rh disease. * Indirect Coombs test (AGT) to assess risk of hemolytic d ...
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