Countercurrent Chromatography
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Countercurrent Chromatography
Countercurrent chromatography (CCC, also counter-current chromatography) is a form of liquid–liquid chromatography that uses a liquid stationary phase that is held in place by inertia of the molecules composing the stationary phase accelerating toward the center of a centrifuge due to centripetal force and is used to separate, identify, and quantify the chemical components of a mixture. In its broadest sense, countercurrent chromatography encompasses a collection of related liquid chromatography techniques that employ two immiscible liquid phases without a solid support. The two liquid phases come in contact with each other as at least one phase is pumped through a column, a hollow tube or a series of chambers connected with channels, which contains both phases. The resulting dynamic mixing and settling action allows the components to be separated by their respective solubilities in the two phases. A wide variety of two-phase solvent systems consisting of at least two immiscible ...
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Lyman C
Lyman may refer to: Places Ukraine * Lyman, Ukraine United States * Lyman, Iowa * Lyman, Maine * Lyman, Mississippi * Lyman, Nebraska * Lyman, New Hampshire * Lyman, Oklahoma * Lyman, South Carolina * Lyman, South Dakota * Lyman County, South Dakota * Lyman, Utah * Lyman, Washington * Lyman, Wyoming Other uses * Lyman (crater), a lunar impact crater * Lyman (name) * Lyman series of hydrogen spectral lines See also * Liman (other) * Lyman High School (other) Lyman High School may refer to: * Lyman Memorial High School, Lebanon, Connecticut * Lyman High School (Florida), Longwood, Florida * Lyman High School (South Dakota), Presho, South Dakota * Lyman High School (Wyoming), Lyman, Wyoming See also ...
* {{disambiguation, geo ...
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Distribution Constant
The distribution constant (or partition ratio) (KD) is the equilibrium constant for the distribution of an analyte in two immiscible solvents.i is the concentration of A remaining after extracting Vaq millilitre The litre (international spelling) or liter (American English spelling) (SI symbols L and l, other symbol used: ℓ) is a metric unit of volume. It is equal to 1 cubic decimetre (dm3), 1000 cubic centimetres (cm3) or 0.001 cubic metre (m3). ...s of solution with the original concentration of sub>0 with ''i'' portions of the organic solvent, each with a volume of Vorg). References {{chromatography Chromatography ...
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Partition Coefficient
In the physical sciences, a partition coefficient (''P'') or distribution coefficient (''D'') is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquids. The partition coefficient generally refers to the concentration ratio of un-ionized species of compound, whereas the distribution coefficient refers to the concentration ratio of all species of the compound (ionized plus un-ionized). In the chemical and pharmaceutical sciences, both phases usually are solvents. Most commonly, one of the solvents is water, while the second is hydrophobic, such as 1-octanol. Hence the partition coefficient measures how hydrophilic ("water-loving") or hydrophobic ("water-fearing") a chemical substance is. Partition coefficients are useful in estimating the distribution of drugs within the body. Hydrophobic drugs with high octanol-water partition coefficients are m ...
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Mass Transfer
Mass transfer is the net movement of mass from one location (usually meaning stream, phase, fraction or component) to another. Mass transfer occurs in many processes, such as absorption, evaporation, drying, precipitation, membrane filtration, and distillation. Mass transfer is used by different scientific disciplines for different processes and mechanisms. The phrase is commonly used in engineering for physical processes that involve diffusive and convective transport of chemical species within physical systems. Some common examples of mass transfer processes are the evaporation of water from a pond to the atmosphere, the purification of blood in the kidneys and liver, and the distillation of alcohol. In industrial processes, mass transfer operations include separation of chemical components in distillation columns, absorbers such as scrubbers or stripping, adsorbers such as activated carbon beds, and liquid-liquid extraction. Mass transfer is often coupled to additional tr ...
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Partitioning Coefficient (Kd)
Partition may refer to: Computing Hardware * Disk partitioning, the division of a hard disk drive * Memory partition, a subdivision of a computer's memory, usually for use by a single job Software * Partition (database), the division of a database * Logical partition (LPAR), a subset of a computer's resources, virtualized as a separate computer Problems * Binary space partitioning * Partition problem, an NP-complete problem in computer science Mathematics * Partition (number theory), a way to write a number as a sum of other numbers * Multiplicative partition, a way to write a number as a product of other numbers * Partition of an interval * Partition of a set * Partition of unity, a certain kind of set of functions on a topological space * Plane partition * Graph partition Natural science * Partition function (quantum field theory) * Partition function (statistical mechanics) * Partition coefficient, a concept in organic chemistry Law and politics * Partition (law), t ...
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Surface-to-volume Ratio
The surface-area-to-volume ratio, also called the surface-to-volume ratio and variously denoted sa/vol or SA:V, is the amount of surface area per unit volume of an object or collection of objects. SA:V is an important concept in science and engineering. It is used to explain the relation between structure and function in processes occurring through the surface ''and'' the volume. Good examples for such processes are processes governed by the heat equation, i.e., diffusion and heat transfer by conduction. SA:V is used to explain the diffusion of small molecules, like oxygen and carbon dioxide between air, blood and cells, water loss by animals, bacterial morphogenesis, organism's thermoregulation, design of artificial bone tissue, artificial lungs and many more biological and biotechnological structures. For more examples see Glazier. The relation between SA:V and diffusion or heat conduction rate is explained from flux and surface perspective, focusing on the surface of a body a ...
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Immiscible
Miscibility () is the property of two chemical substance, substances to mix in all mixing ratio, proportions (that is, to fully dissolution (chemistry), dissolve in each other at any concentration), forming a homogeneity and heterogeneity, homogeneous mixture (a Solution (chemistry), solution). The term is most often applied to liquids but also applies to solids and gases. For example, water and ethanol are miscible because they mix in all proportions. By contrast, substances are said to be immiscible if there are certain proportions in which the mixture does not form a solution. For one example, oil is not soluble in water, so these two solvents are immiscible. As another example, butanone (methyl ethyl ketone) is significantly soluble in water, but these two solvents are also immiscible because in some proportions the mixture will separate into two Phase (matter), phases. Organic compounds In organic compounds, the Concentration#Mass percentage (fraction), weight percent of h ...
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Normal Phase Chromatography
High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorption, adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out of the column. HPLC has been used for manufacturing (''e.g.'', during the production process of pharmaceutical and biological products), legal (''e.g.'', detecting performance enhancement drugs in urine), research (''e.g.'', separating the components of a complex biological sample, or of similar synthetic chemicals from each other), and medical (''e.g.'', detecting vitamin D levels in blood serum) purpo ...
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Adsorption
Adsorption is the adhesion of atoms, ions or molecules from a gas, liquid or dissolved solid to a surface. This process creates a film of the ''adsorbate'' on the surface of the ''adsorbent''. This process differs from absorption, in which a fluid (the ''absorbate'') is dissolved by or permeates a liquid or solid (the ''absorbent''). Adsorption is a '' surface phenomenon'', while absorption involves the whole volume of the material, although adsorption does often precede absorption. The term ''sorption'' encompasses both processes, while ''desorption'' is the reverse of it. Like surface tension, adsorption is a consequence of surface energy. In a bulk material, all the bonding requirements (be they ionic, covalent or metallic) of the constituent atoms of the material are fulfilled by other atoms in the material. However, atoms on the surface of the adsorbent are not wholly surrounded by other adsorbent atoms and therefore can attract adsorbates. The exact nature of the bon ...
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Silica Gel
Silica gel is an amorphous and porous form of silicon dioxide (silica), consisting of an irregular tridimensional framework of alternating silicon and oxygen atoms with nanometer-scale voids and pores. The voids may contain water or some other liquids, or may be filled by gas or vacuum. In the last case, the material is properly called silica xerogel. Silica xerogel with an average pore size of 2.4 nanometers has a strong affinity for water molecules and is widely used as a desiccant. It is hard and translucent, but considerably softer than massive silica glass or quartz; and remains hard when saturated with water. Silica xerogel is usually commercialized as coarse granules or beads, a few millimeters in diameter. Some grains may contain small amounts of indicator substance that changes color when they have absorbed some water. Small paper envelopes containing silica xerogel pellets, usually with a "do not eat" warning, are often included in dry food packages to absorb any h ...
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Microporous Material
A microporous material is a material containing pores with diameters less than 2 nm. Examples of microporous materials include zeolites and metal-organic frameworks. Porous materials are classified into several kinds by their size. The recommendations of a panel convened by the International Union of Pure and Applied Chemistry (IUPAC) are: See page 1745. *Microporous materials have pore diameters of less than 2 nm. *Mesoporous materials have pore diameters between 2 nm and 50 nm. *Macroporous materials have pore diameters of greater than 50 nm. Micropores may be defined differently in other contexts. For example, in the context of porous aggregations such as soil, micropores are defined as cavities with sizes less than 30 μm. Uses in laboratories Microporous materials are often used in laboratory environments to facilitate contaminant-free exchange of gases. Mold spores, bacteria, and other airborne contaminants will become trapped, while gases are ...
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