Connectome (book)
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Connectome (book)
''Connectome: How the Brain's Wiring Makes Us Who We Are'' (2012) is a book by Sebastian Seung. It introduces basic concepts in neuroscience and then elaborates on the field of connectomics, i.e., how to scan, decode, compare, and understand patterns in brain connectivity. The book concludes with musings on cryonics and mind uploading. It was selected by ''The Wall Street Journal'' as Top Ten Nonfiction of 2012. Book outline Introduction Seung frames the idea of connectomics and argues that "You are more than your genes. You are your connectome." Ch. 1: Genius and Madness Seung introduces the 19th-century idea of phrenology and its modern-day counterpart, which he calls "neo-phrenology", i.e., the idea that sizes of brain regions play a role in intelligence (e.g., Einstein's enlarged inferior parietal lobule) or mental disorders (e.g., schizophrenia and autism). That said, Seung emphasizes that these size correlations only show up for large samples and can't necessarily predict ...
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Sebastian Seung
Hyunjune Sebastian Seung (English: /sung/ or əŋ ) is President at Samsung Electronics & Head of Samsung Research and Anthony B. Evnin Professor in the Princeton Neuroscience Institute and Department of Computer Science. Seung has done influential research in both computer science and neuroscience. He has helped pioneer the new field of connectomics, "developing new computational technologies for mapping the connections between neurons," and has been described as the cartographer of the brain. Since 2014, he has been a professor in computer science and neuroscience at Princeton University's Neuroscience Institute at the Jeff Bezos Center in Neural Dynamics, where he directs the Seung Labs. Before, he worked at the Massachusetts Institute of Technology as a full professor in computational neuroscience in the Department of Brain and Cognitive Sciences and as a professor in physics. In the industry, he was a research scientist at the Bell Labs and an Investigator of the Howard Hu ...
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Neurites
A neurite or neuronal process refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete. Neurite development The development of a neurite requires a complex interplay of both extracellular and intracellular signals. At every given point along a developing neurite, there are receptors detecting both positive and negative growth cues from every direction in the surrounding space. The developing neurite sums together all of these growth signals in order to determine which direction the neurite will ultimately grow towards. While not all of the growth signals are known, several have been identified and characterized. Among the known extracellular growth signals are netrin, a midline chemoattractant, and semaphorin, ephrin and colla ...
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Compact Disc
The compact disc (CD) is a Digital media, digital optical disc data storage format that was co-developed by Philips and Sony to store and play digital audio recordings. In August 1982, the first compact disc was manufactured. It was then released in October 1982 in Japan and branded as ''Compact Disc Digital Audio, Digital Audio Compact Disc''. The format was later adapted (as CD-ROM) for general-purpose data storage. Several other formats were further derived, including write-once audio and data storage (CD-R), rewritable media (CD-RW), Video CD (VCD), Super Video CD (SVCD), Photo CD, Picture CD, Compact Disc-Interactive (CD-i) and Enhanced Music CD. Standard CDs have a diameter of and are designed to hold up to 74 minutes of uncompressed stereo digital audio or about 650 mebibyte, MiB of data. Capacity is routinely extended to 80 minutes and 700 mebibyte, MiB by arranging data more closely on the same sized disc. The Mini CD has various diameters ranging from ; t ...
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HVC (avian Brain Region)
HVC (formerly, hyperstriatum ventrale, pars caudalis (HVc), and high vocal center) is a nucleus in the brain of the songbirds (order passeriformes) necessary for both the learning and the production of bird song. It is located in the lateral caudal nidopallium and has projections to both the Bird vocalization#Neuroanatomy, direct and the anterior forebrain pathways. It is notable that both of the other orders of birds that learn song, the hummingbirds and parrots, also seem to have structures similar to HVC. Since it is believed that all three of these groups independently derived the ability to learn song, it is believed that these other HVC-like structures are examples of homoplasy. Name HVC was originally called the hyperstriatum ventrale, pars caudalis (HVc). Later neuroanatomy revealed this name to be incorrect, however, and many researchers referred to it as the high vocal center due to its important function in vocal learning. When the nomenclature of the avian brain was off ...
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Santiago Ramón Y Cajal
Santiago Ramón y Cajal (; 1 May 1852 – 17 October 1934) was a Spanish neuroscientist, pathologist, and histologist specializing in neuroanatomy and the central nervous system. He and Camillo Golgi received the Nobel Prize in Physiology or Medicine in 1906. Ramón y Cajal was the first person of Spanish origin to win a scientific Nobel Prize. His original investigations of the microscopic structure of the brain made him a pioneer of modern neuroscience. Hundreds of his drawings illustrating the arborizations ("tree growing") of brain cells are still in use, since the mid-20th century, for educational and training purposes. Biography Santiago Ramón y Cajal was born on the 1st of May 1852 in the town of Petilla de Aragón, Navarre, Spain. As a child he was transferred many times from one school to another because of behavior that was declared poor, rebellious, and showing an anti-authoritarian attitude. An extreme example of his precociousness and rebelliousness at the age of ...
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Brodmann Areas
A Brodmann area is a region of the cerebral cortex, in the human or other primate brain, defined by its cytoarchitecture, or histological structure and organization of cells. History Brodmann areas were originally defined and numbered by the German anatomist Korbinian Brodmann based on the cytoarchitectural organization of neurons he observed in the cerebral cortex using the Nissl method of cell staining. Brodmann published his maps of cortical areas in humans, monkeys, and other species in 1909, along with many other findings and observations regarding the general cell types and laminar organization of the mammalian cortex. The same Brodmann area number in different species does not necessarily indicate homologous areas. A similar, but more detailed cortical map was published by Constantin von Economo and Georg N. Koskinas in 1925. Present importance Brodmann areas have been discussed, debated, refined, and renamed exhaustively for nearly a century and remain the most wid ...
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Korbinian Brodmann
Korbinian Brodmann (17 November 1868 – 22 August 1918) was a German neurologist who became famous for mapping the cerebral cortex and defining 52 distinct regions, known as Brodmann areas, based on their cytoarchitectonic (histological) characteristics. Life and career Brodmann was born in Liggersdorf, Province of Hohenzollern. He studied medicine in Munich, Würzburg, Berlin, and Freiburg, where he received his medical diploma in 1895. Subsequently he studied at the Medical School in the University of Lausanne in Switzerland, and then worked in the University Clinic in Munich. He received a doctor of medicine degree from the University of Leipzig in 1898, with a thesis on chronic ependymal sclerosis. From 1900 to 1901, Brodmann also worked in the Psychiatric Clinic at the University of Jena, with Ludwig Binswanger, and in the Municipal Mental Asylum in Frankfurt. There, he met Alois Alzheimer, who was influential in his decision to pursue basic neuroscience research. Fol ...
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Intelligence Amplification
Intelligence amplification (IA) (also referred to as cognitive augmentation, machine augmented intelligence and enhanced intelligence) refers to the effective use of information technology in augmenting human intelligence. The idea was first proposed in the 1950s and 1960s by cybernetics and early computer pioneers. IA is sometimes contrasted with AI (artificial intelligence), that is, the project of building a human-like intelligence in the form of an autonomous technological system such as a computer or robot. AI has encountered many fundamental obstacles, practical as well as theoretical, which for IA seem moot, as it needs technology merely as an extra support for an autonomous intelligence that has already proven to function. Moreover, IA has a long history of success, since all forms of information technology, from the abacus to writing to the Internet, have been developed basically to extend the information processing capabilities of the human mind (see extended mind and d ...
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Artificial Intelligence
Artificial intelligence (AI) is intelligence—perceiving, synthesizing, and inferring information—demonstrated by machines, as opposed to intelligence displayed by animals and humans. Example tasks in which this is done include speech recognition, computer vision, translation between (natural) languages, as well as other mappings of inputs. The ''Oxford English Dictionary'' of Oxford University Press defines artificial intelligence as: the theory and development of computer systems able to perform tasks that normally require human intelligence, such as visual perception, speech recognition, decision-making, and translation between languages. AI applications include advanced web search engines (e.g., Google), recommendation systems (used by YouTube, Amazon and Netflix), understanding human speech (such as Siri and Alexa), self-driving cars (e.g., Tesla), automated decision-making and competing at the highest level in strategic game systems (such as chess and Go). ...
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Sydney Brenner
Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work on the genetic code, and other areas of molecular biology while working in the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, England. He established the roundworm ''Caenorhabditis elegans'' as a model organism for the investigation of developmental biology, and founded the Molecular Sciences Institute in Berkeley, California, United States.''The Science Times Book of the Brain'' 1998. Edited by Nicholas Wade. The Lyons Press Horace Freeland Judson ''The Eighth Day of Creation'' (1979), pp. 10–11 ''Makers of the Revolution in Biology''; Penguin Books 1995, first published by Jonathan Cape, 1977; ."Sydney Brenner: A Biography" by Errol Friedberg, pub. CSHL Press October 2010, . Education and early life Br ...
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Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ...
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Hard Drive
A hard disk drive (HDD), hard disk, hard drive, or fixed disk is an electro-mechanical data storage device that stores and retrieves digital data using magnetic storage with one or more rigid rapidly rotating platters coated with magnetic material. The platters are paired with magnetic heads, usually arranged on a moving actuator arm, which read and write data to the platter surfaces. Data is accessed in a random-access manner, meaning that individual blocks of data can be stored and retrieved in any order. HDDs are a type of non-volatile storage, retaining stored data when powered off. Modern HDDs are typically in the form of a small rectangular box. Introduced by IBM in 1956, HDDs were the dominant secondary storage device for general-purpose computers beginning in the early 1960s. HDDs maintained this position into the modern era of servers and personal computers, though personal computing devices produced in large volume, like cell phones and tablets, rely on ...
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