Combretol
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Combretol
Combretol is an O-methylated flavonol, a type of flavonoid. It is the 3,7,3',4',5'-O-methylation of myricetin and can be extracted from ''Combretum quadrangulare'' and from ''Rhodomyrtus tomentosa ''Rhodomyrtus tomentosa'' also known as rose myrtle, is a flowering plant in the family Myrtaceae, native to southern and southeastern Asia, from India, east to southern China, Hong Kong, Taiwan and the Philippines, and south to Malaysia and S ...''. References O-methylated flavonols Methoxy compounds {{aromatic-stub ...
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Combretum Quadrangulare
''Combretum quadrangulare'' is a small tree of the family Combretaceae, up to 10 m high. The tree grows wildly or is planted in Vietnam, Cambodia, Laos, Myanmar and Thailand. The tree is planted along the banks of rivers or arroyos for firing. It is found throughout Thailand especially in open, wet places. Therapeutic uses of this plant in the country are for anthelmintics (the parts used were seeds, roots and leaves) and curing venereal disease (the parts used are roots and wood). Studies of the chemical constituents of this plant have revealed that alcoholic and other extracts from the roots and seeds could kill earthworms. Extracts from seeds display antibacterial properties. Description Tree, 5-10m high: young branchlets acutely quad-rangular or very narrowly quadrialate. Leaves simple, opposite, elliptic or obovate, 3–8 cm wide, 6–16 cm long: petiole acutely ridged. Inflorescence in terminal and axillary spike; flower small, yellowish white. Fruit dry, thi ...
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O-methylated Flavonol
The O-methylated flavonoids or methoxyflavonoids are flavonoids with methylations on hydroxyl groups (methoxy bonds). O-methylation has an effect on the solubility of flavonoids. Enzymes O-methylated flavonoids formation implies the presence of specific O-methyltransferase (OMT) enzymes which accept a variety of substrates. Those enzymes mediate the O-methylation on a specific hydroxyl group, like on 4' (example in ''Catharanthus roseus'') or 3' (example in rice) positions. Those positions can be ortho, meta, para and there can be a special 3-O-methyltransferase for the 3-OH position. Calamondin orange ('' Citrus mitis'') exhibits all of those activities. Plant enzymes * Apigenin 4'-O-methyltransferase * 8-hydroxyquercetin 8-O-methyltransferase * Isoflavone 4'-O-methyltransferase * Isoflavone 7-O-methyltransferase * Isoliquiritigenin 2'-O-methyltransferase * Isoorientin 3'-O-methyltransferase * Kaempferol 4'-O-methyltransferase * Luteolin O-methyltransferase * Methylquercet ...
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Myricetin
Myricetin is a member of the flavonoid class of polyphenolic compounds, with antioxidant properties. Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Reported average intake of myricetin per day varies depending on diet, but has been shown in the Netherlands to average 23 mg/day. Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). Myricetin can alternatively be produced directly from kae ...
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Rhodomyrtus Tomentosa
''Rhodomyrtus tomentosa'' also known as rose myrtle, is a flowering plant in the family Myrtaceae, native to southern and southeastern Asia, from India, east to southern China, Hong Kong, Taiwan and the Philippines, and south to Malaysia and Sulawesi. It grows in coasts, natural forest, riparian zones, wetlands, moist and wet forests, bog margins, from sea level up to 2400 m elevation. Description ''Rhodomyrtus tomentosa'' is an evergreen shrub growing up to 4 m (12 feet) tall. The leaves are opposite, leathery, 5–7 cm long and 2-3.5 cm broad, three-veined from the base, oval, obtuse to sharp pointed at the tip, glossy green above, densely grey or rarely yellowish-hairy beneath, with a wide petiole and an entire margin. The flowers are solitary or in clusters of two or three, 2.5–3 cm diameter, with five petals which are tinged white on the outside with purplish-pink or all pink. The fruit is edible, 10–15 mm long, purple, round, three or four-c ...
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