Clinical Cell Culture
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Clinical Cell Culture
Avita Medical is a clinical and commercial company developing and marketing a range of respiratory and regenerative products. The first regenerative medicine product brought to the market by Avita Medical was ReCell spray-on skin for the treatment of burns. The two latest products are ReNovaCell, for Aesthetics and Plastic applications including skin trauma, and ReGenerCell for the treatment of chronic wounds. The Avita Medical regenerative product range is currently marketed in Europe, the Middle East, Africa (EMEA) and Australia. Company history Originally named "Clinical Cell Culture" and listed on the ASX under the symbol "C3", the company restructured under the name "Avita Medical" in June 2008. In 2015, the company conducted a strategic divestment of its respiratory business, including the Breath-a-Tech and Funhaler products, to support focus on its regenerative products. Avita Medical is traded both on the Australian stock market under the ticker symbol AVH and on the Ameri ...
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Public Company
A public company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states, and therefore have associations and formal designations which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation (though a corporation need not be a public company), in the United Kingdom it is usually a public limited company (plc), i ...
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Fiona Wood
Fiona Melanie Wood (born 2 February 1958) is an English-born Australian plastic surgeon working in Perth, Western Australia. She is the director of the Royal Perth Hospital burns unit and the Western Australia Burns Service. In addition, Wood is also a clinical professor with the School of Paediatrics and Child Health at the University of Western Australia and director of the McComb Research Foundation. Early life and education Wood was born in Yorkshire, England, 2 February 1958. She attended Ackworth School near Pontefract, West Yorkshire. She was athletic as a child and hoped for a career as an Olympic sprinter, before training at a university and then St Thomas's Hospital Medical School in London, graduating from there in 1981. Career and research Wood worked at a major British hospital before marrying Western Australian born surgeon Tony Kierath and migrating to Perth with their first two children in 1987. She completed her training in plastic surgery between having ...
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Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differenti ...
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Spray-on Skin
Spray-on skin is a skin culturing treatment for burn, or other skin damage victims. It involves taking small samples of the patient's skin and spraying them on the wound. History The treatment was developed by Marie Stoner and plastic surgeon Fiona Wood. Their technique worked quicker than previous skin culturing techniques. Wood established the company Avita Medical in 1993 to commercialise the procedure. After the 2002 Bali bombings, Wood used the experimental technology on victims before it had been subjected to proper clinical trials, garnering criticism from other burn specialists since at the time there was little evidence of its efficacy, and Wood had an apparent conflict of interest since she founded the company that sold the technology. A 2006 clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (su ...
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Burn
A burn is an injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or ultraviolet radiation (like sunburn). Most burns are due to heat from hot liquids (called scalding), solids, or fire. Burns occur mainly in the home or the workplace. In the home, risks are associated with domestic kitchens, including stoves, flames, and hot liquids. In the workplace, risks are associated with fire and chemical and electric burns. Alcoholism and smoking are other risk factors. Burns can also occur as a result of self-harm or violence between people (assault). Burns that affect only the superficial skin layers are known as superficial or first-degree burns. They appear red without blisters and pain typically lasts around three days. When the injury extends into some of the underlying skin layer, it is a partial-thickness or second-degree burn. Blisters are frequently present and they are often very painful. Healing can require up to eight weeks and scarri ...
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Skin Trauma
Skin trauma is serious and altering physical injury experienced by the skin or multiple layers of epithelial tissue Epithelium or epithelial tissue is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. It is a thin, continuous, protective layer of compactly packed cells with a little intercellu ...s. This can be in the form of cuts, burns, sickness or other injury. References Dermatologic terminology Cutaneous lesion {{dermatology-stub ...
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Europe, The Middle East And Africa
EMEA is a shorthand designation meaning Europe, the Middle East and Africa. The acronym is used by institutions and governments, as well as in marketing and business when referring to this region: it is a shorthand way of referencing the two continents (Africa and Europe) and the Middle Eastern sub-continent all at once. It is particularly common among North American companies, and it is mostly used when dividing a company's operations by geography. As the name suggests, the region includes all of the countries found on the continents of Africa and Europe, as well as the countries that make up the Middle East. The region is generally accepted to include all European nations and all African nations, and extends east to Iran, including part of Russia. It may also include Kazakhstan and the rest of Central Asia. Typically, the acronym does not include independent overseas territories of mainland countries in the region, such as French Guiana. However, the term is not completely ...
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Australian Securities Exchange
Australian Securities Exchange Ltd or ASX, is an Australian public company that operates Australia's primary securities exchange, the Australian Securities Exchange (sometimes referred to outside of Australia as, or confused within Australia as, The Sydney Stock Exchange, a separate entity). The ASX was formed on 1 April 1987, through incorporation under legislation of the Australian Parliament as an amalgamation of the six state securities exchanges, and merged with the Sydney Futures Exchange in 2006. Today, ASX has an average daily turnover of A$4.685 billion and a market capitalisation of around A$1.6 trillion, making it one of the world's top 20 listed exchange groups. ASX Clear is the clearing house for all shares, structured products, warrants and ASX Equity Derivatives. Overview ASX Group is a market operator, clearing house and payments system facilitator. It also oversees compliance with its operating rules, promotes standards of corporate governance am ...
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Biomedical Advanced Research And Development Authority
The Biomedical Advanced Research and Development Authority (BARDA) is a U.S. Department of Health and Human Services (HHS) office responsible for the procurement and development of medical countermeasures, principally against bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats, as well as pandemic influenza and emerging diseases. BARDA was established in 2006 through the Pandemic and All-Hazards Preparedness Act (PAHPA) and reports to the Office of the Assistant Secretary for Preparedness and Response (ASPR). The office manages Project BioShield, which funds the research, development and stockpiling of vaccines and treatments that the government could use during public health emergencies such as chemical, biological, radiological or nuclear (CBRN) attacks. In addition to preparing and maintaining bioterrorism responses and countermeasures, HHS, through the ASPR and BARDA, prepares and maintains an integrated system of medical countermeasu ...
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Pediatric Burn
A pediatric burn is an injury to the skin or underlying tissue in person under the age of 18, and is globally the most common type of pediatric injury. Burns can be caused my heat, cold, chemical or irritation. Most burns do not require hospital admission but a small percentage are serious and need to be transferred to specialist burn centers, where a multidisciplinary team of specially trained doctors, including surgeons and anesthesiologists can care for the child. Mortality rates at centers like this at are recorded at 3%. Signs and symptoms There are three types of burns; * Superficial burn * Partial thickness burn * Full thickness burn Depending on the type of burn that has occurred, there will be different signs and symptoms. A superficial burn has damaged the epidermis, and this appears as redness. A partial thickness burn has damaged the epidermis and underlying dermis, and is red, painful and often blisters A full thickness burn has damaged the epidermis and the e ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ...
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Necrotizing Fasciitis
Necrotizing fasciitis (NF), also known as flesh-eating disease, is a bacterial infection that results in the death of parts of the body's soft tissue. It is a severe disease of sudden onset that spreads rapidly. Symptoms usually include red or purple skin in the affected area, severe pain, fever, and vomiting. The most commonly affected areas are the limbs and perineum. Typically, the infection enters the body through a break in the skin such as a cut or burn. Risk factors include poor immune function such as from diabetes or cancer, obesity, alcoholism, intravenous drug use, and peripheral artery disease. It does not typically spread between people. The disease is classified into four types, depending on the infecting organism. Between 55 and 80% of cases involve more than one type of bacteria. Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is involved in up to a third of cases. Medical imaging is often helpful to confirm the diagnosis. Necrotizing fasciitis may b ...
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