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CiteAb
CiteAb Limited is a life science data company located in Bath, England that offers an antibody, biochemicals, experimental models, kits and protein search tool to aid biomedical scientists in their research. History and operations CiteAb started in 2013 as an academic project by Dr Andrew Chalmers, a senior lecturer at the University of Bath. The resource was established to help scientific researchers find suitable antibodies for their experiments - such antibodies can be helpful in context of screenings, therapeutic development, and drug discovery. CiteAb ranks antibodies by citations, making it possible for researchers to find reagents that have been successfully used in past research papers. The accompanying citations are listed, so the data contained within the publications can also be checked. The CiteAb platform was built in collaboration with technology company Storm Consultancy, in Bath, in 2012. A trial website was soft-launched in September 2012 before the full ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotech
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Sciences
This list of life sciences comprises the branches of science that involve the scientific study of life – such as microorganisms, plants, and animals including human beings. This science is one of the two major branches of natural science, the other being physical science, which is concerned with non-living matter. Biology is the overall natural science that studies life, with the other life sciences as its sub-disciplines. Some life sciences focus on a specific type of organism. For example, zoology is the study of animals, while botany is the study of plants. Other life sciences focus on aspects common to all or many life forms, such as anatomy and genetics. Some focus on the micro-scale (e.g. molecular biology, biochemistry) other on larger scales (e.g. cytology, immunology, ethology, pharmacy, ecology). Another major branch of life sciences involves understanding the mindneuroscience. Life sciences discoveries are helpful in improving the quality and standard of life and h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few varia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Companies House
Companies House is the executive agency of the company registrars of the United Kingdom, falling under the remit of the Department for Business, Energy and Industrial Strategy. All forms of companies (as permitted by the Companies Act) are incorporated and registered with Companies House and file specific details as required by legislation. All registered limited companies, including subsidiary, small and inactive companies, must file annual financial statements in addition to annual company returns, and all these are public records. Only some registered unlimited companies (meeting certain conditions) are exempt from this requirement. The United Kingdom has had a system of company registration since 1844. The legislation governing company registration matters is the Companies Act 2006. History 19th century Prior to 1844, companies could only be incorporated through grant of a royal charter, by private act of Parliament, or, from 1834, by letters patent. Few companie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bath, Somerset
Bath () is a city in the Bath and North East Somerset unitary area in the county of Somerset, England, known for and named after its Roman-built baths. At the 2021 Census, the population was 101,557. Bath is in the valley of the River Avon, west of London and southeast of Bristol. The city became a World Heritage Site in 1987, and was later added to the transnational World Heritage Site known as the "Great Spa Towns of Europe" in 2021. Bath is also the largest city and settlement in Somerset. The city became a spa with the Latin name ' ("the waters of Sulis") 60 AD when the Romans built baths and a temple in the valley of the River Avon, although hot springs were known even before then. Bath Abbey was founded in the 7th century and became a religious centre; the building was rebuilt in the 12th and 16th centuries. In the 17th century, claims were made for the curative properties of water from the springs, and Bath became popular as a spa town in the Georgian era. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Bath
(Virgil, Georgics II) , mottoeng = Learn the culture proper to each after its kind , established = 1886 (Merchant Venturers Technical College) 1960 (Bristol College of Science and Technology) 1966 (Bath University of Technology) 1971 (university status) , type = Public , endowment = £8.1 million (2021) , budget = £289.5 million (2020–21) , chancellor = The Earl of Wessex , vice_chancellor = Ian H. White , academic_staff = 2,180 (2020) - including academic atypical staff , students = () , undergrad = () , postgrad = () , doctoral = , city = Bath, Somerset , country = England , coor = , campus = Suburban , free_label = , free = , website www.bath.ac.uk, logo = University of Bath logo.svg , affiliations = Association of Commonwealth Universities, ACUAssociation of MBAs, AMBAEuropean Quality Improvement System, EQUISEuropean University Association, EUAUniversities UK Wallace Group (universities), Wallace GroupGW4Sutton_Trust_30, Sutton 30SETs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High-content Screening
High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery to identify substances such as small molecules, peptides, or RNAi that alter the phenotype of a cell in a desired manner. Hence high content screening is a type of phenotypic screen conducted in cells involving the analysis of whole cells or components of cells with simultaneous readout of several parameters. HCS is related to high-throughput screening (HTS), in which thousands of compounds are tested in parallel for their activity in one or more biological assays, but involves assays of more complex cellular phenotypes as outputs. Phenotypic changes may include increases or decreases in the production of cellular products such as proteins and/or changes in the morphology (visual appearance) of the cell. Hence HCA typically involves automated microscopy and image analysis. Unlike high-content analysis, high-content screening implies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monoclonal Antibody Therapy
Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAbs) to bind monospecifically to certain cells or proteins. The objective is that this treatment will stimulate the patient's immune system to attack those cells. Alternatively, in radioimmunotherapy a radioactive dose localizes a target cell line, delivering lethal chemical doses. Antibodies have been used to bind to molecules involved in T-cell regulation to remove inhibitory pathways that block T-cell responses. This is known as immune checkpoint therapy. It is possible to create a mAb that is specific to almost any extracellular/cell surface target. Research and development is underway to create antibodies for diseases (such as rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Ebola and different types of cancers). Antibody structure and function Immunoglobulin G (IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibody-drug Conjugate
Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. As of 2019, some 56 pharmaceutical companies were developing ADCs. ADCs are complex molecules composed of an antibody linked to a biologically active cytotoxic (anticancer) payload or drug. Antibody-drug conjugates are an example of bioconjugates and immunoconjugates. ADCs combine the targeting properties of Monoclonal antibody, monoclonal antibodies with the cancer-killing capabilities of cytotoxic drugs, designed to discriminate between healthy and diseased tissue. Mechanism of action An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein) that, ideally, is only found in or on tumor cells. Antibodies attach themselves to the antigens on the surface of cancerous cells. The biochemical reaction that occurs upon attaching ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Engineering And Physical Sciences Research Council
The Engineering and Physical Sciences Research Council (EPSRC) is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences, mainly to universities in the United Kingdom. EPSRC research areas include mathematics, physics, chemistry, artificial intelligence and computer science, but exclude particle physics, nuclear physics, space science and astronomy (which fall under the remit of the Science and Technology Facilities Council). Since 2018 it has been part of UK Research and Innovation, which is funded through the Department for Business, Energy and Industrial Strategy. History EPSRC was created in 1994. At first part of the Science and Engineering Research Council (SERC), in 2018 it was one of nine organisations brought together to form UK Research and Innovation (UKRI). Its head office is in Swindon, Wiltshire in the same building (Polaris House) that houses the AHRC, BBSRC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Higher Education Funding Council For England
The Higher Education Funding Council for England (HEFCE) was a non-departmental public body in the United Kingdom, which was responsible for the distribution of funding for higher education to universities and further education colleges in England since 1992. It ceased to exist as of 1 April 2018, when its duties were divided between the newly created Office for Students and Research England (operating within United Kingdom Research and Innovation). Most universities are charities and HEFCE (rather than the Charity Commission for England and Wales) was their principal regulator. HEFCE therefore had the duty to promote compliance with charity law by the universities for which it was responsible. History HEFCE was created by the Further and Higher Education Act 1992 (which also created the Further Education Funding Council for England (FEFC), replaced in 2001 by the Learning and Skills Council). On 1 June 2010 HEFCE became the principal regulator of those higher education institu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Enterprise Partnership
In England, local enterprise partnerships (LEPs) are voluntary partnerships between local authorities and businesses, set up in 2011 by the Department for Business, Innovation and Skills to help determine local economic priorities and lead economic growth and job creation within the local area. They carry out some of the functions previously carried out by the regional development agencies which were abolished in March 2012. In certain areas, funding is received from the UK government via growth deals. After the March 2017 merger of Northamptonshire LEP into South East Midlands LEP, there were 38 local enterprise partnerships in operation. History The abolition of regional development agencies and the creation of local enterprise partnerships were announced as part of the June 2010 United Kingdom budget. On 29 June 2010 a letter was sent from the Department for Communities and Local Government and the Department for Business, Innovation and Skills to local authority and bus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
