Chloride Channel Blockers
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Chloride Channel Blockers
The chloride ion is the anion (negatively charged ion) Cl−. It is formed when the element chlorine (a halogen) gains an electron or when a compound such as hydrogen chloride is dissolved in water or other polar solvents. Chloride salts such as sodium chloride are often very soluble in water.Green, John, and Sadru Damji. "Chapter 3." ''Chemistry''. Camberwell, Vic.: IBID, 2001. Print. It is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating liquid flow in and out of cells. Less frequently, the word ''chloride'' may also form part of the "common" name of chemical compounds in which one or more chlorine atoms are covalently bonded. For example, methyl chloride, with the standard name chloromethane (see IUPAC books) is an organic compound with a covalent C−Cl bond in which the chlorine is not an anion. Electronic properties A chloride ion (diameter 167  pm) is much larger t ...
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Hydrogen Chloride
The compound hydrogen chloride has the chemical formula and as such is a hydrogen halide. At room temperature, it is a colourless gas, which forms white fumes of hydrochloric acid upon contact with atmospheric water vapor. Hydrogen chloride gas and hydrochloric acid are important in technology and industry. Hydrochloric acid, the aqueous solution of hydrogen chloride, is also commonly given the formula HCl. Reactions Hydrogen chloride is a diatomic molecule, consisting of a hydrogen atom H and a chlorine atom Cl connected by a polar covalent bond. The chlorine atom is much more electronegative than the hydrogen atom, which makes this bond polar. Consequently, the molecule has a large dipole moment with a negative partial charge (δ−) at the chlorine atom and a positive partial charge (δ+) at the hydrogen atom. In part because of its high polarity, HCl is very soluble in water (and in other polar solvents). Upon contact, and HCl combine to form hydronium cations and ...
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Picometre
The picometre (international spelling as used by the International Bureau of Weights and Measures; SI symbol: pm) or picometer (American spelling) is a unit of length in the International System of Units (SI), equal to , or one trillionth of a metre, which is the SI base unit of length. The picometre is one thousand femtometres, one thousandth of a nanometre ( nm), one millionth of a micrometre (also known as a micron), one billionth of a millimetre, and one trillionth of a metre. The symbol μμ was once used for it. It is also one hundredth of an ångström, an internationally known (but non-SI) unit of length. Use The picometre's length is of an order so small that its application is almost entirely confined to particle physics, quantum physics, chemistry and acoustics. Atoms are between 62 and 520 pm in diameter, and the typical length of a carbon–carbon single bond is 154 pm. Smaller units still may be used to describe smaller particles (some of which are ...
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Silver Chloride Electrode
A silver chloride electrode is a type of reference electrode, commonly used in electrochemical measurements. For environmental reasons it has widely replaced the saturated calomel electrode. For example, it is usually the internal reference electrode in pH meters and it is often used as reference in reduction potential measurements. As an example of the latter, the silver chloride electrode is the most commonly used reference electrode for testing cathodic protection corrosion control systems in sea water environments. The electrode functions as a reversible redox electrode and the equilibrium is between the solid (s) silver metal (Ag(s)) and its solid salt—silver chloride (AgCl(s), also called silver(I) chloride) in a chloride solution of a given concentration. In electrochemical cell notation, the silver chloride electrode is written as, ''e.g.'', for an electrolyte solution of KCl 3 M: : \ , \ \ , \ KCl \ (3M) The corresponding half-reactions can be presented as follows ...
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Chloridometer
A chloridometer is a measuring instrument used to determine the concentration of chloride ions (Cl–) in a solution. It uses a process known as coulometric titration or ''amperostatic coulometry'', the accepted electrochemistry reference method to determine the concentration of chloride in biological fluids, including blood serum, blood plasma, urine, sweat, and cerebrospinal fluid. The coulometry process generates silver ions, which react with the chloride to form silver chloride (AgCl). The first chloridometer was designed by a team led by Ernest Cotlove in 1958. Other methods to determine chloride concentration include photometric titration and isotope dilution mass spectrometry. Operation An amperostat delivers a constant current of about 6—8  mA to the generator electrodes for the titration of the solution, and a digital timer is started. A second pair of silver electrodes are used as a detector to measure the conductance of the solution. The same constant curren ...
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Silver Nitrate
Silver nitrate is an inorganic compound with chemical formula . It is a versatile precursor to many other silver compounds, such as those used in photography. It is far less sensitive to light than the halides. It was once called ''lunar caustic'' because silver was called ''luna'' by ancient alchemists who associated silver with the moon. In solid silver nitrate, the silver ions are three- coordinated in a trigonal planar arrangement. Synthesis and structure Albertus Magnus, in the 13th century, documented the ability of nitric acid to separate gold and silver by dissolving the silver. Indeed silver nitrate can be prepared by dissolving silver in nitric acid followed by evaporation of the solution. The stoichiometry of the reaction depends upon the concentration of nitric acid used. :3 Ag + 4 HNO3 (cold and diluted) → 3 AgNO3 + 2 H2O + NO :Ag + 2 HNO3 (hot and concentrated) → AgNO3 + H2O + NO2 The structure of silver nitrate has been examined by X-ray crystallography sever ...
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Strong Acid
Acid strength is the tendency of an acid, symbolised by the chemical formula HA, to dissociate into a proton, H+, and an anion, A-. The dissociation of a strong acid in solution is effectively complete, except in its most concentrated solutions. :HA -> H+ + A- Examples of strong acids are hydrochloric acid (HCl), perchloric acid (HClO4), nitric acid (HNO3) and sulfuric acid (H2SO4). A weak acid is only partially dissociated, with both the undissociated acid and its dissociation products being present, in solution, in equilibrium with each other. :HA H+ + A- Acetic acid (CH3COOH) is an example of a weak acid. The strength of a weak acid is quantified by its acid dissociation constant, K_\ce value. The strength of a weak organic acid may depend on substituent effects. The strength of an inorganic acid is dependent on the oxidation state for the atom to which the proton may be attached. Acid strength is solvent-dependent. For example, hydrogen chloride is a strong acid in ...
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Weak Base
A weak base is a base that, upon dissolution in water, does not dissociate completely, so that the resulting aqueous solution contains only a small proportion of hydroxide ions and the concerned basic radical, and a large proportion of undissociated molecules of the base. pH, Kb, and Kw Bases yield solutions in which the hydrogen ion activity is lower than it is in pure water, i.e., the solution is said to have a pH greater than 7.0 at standard conditions, potentially as high as 14 (and even greater than 14 for some bases). The formula for pH is: :\mbox = -\log_ \left \mbox^+ \right/math> Bases are proton acceptors; a base will receive a hydrogen ion from water, H2O, and the remaining H+ concentration in the solution determines pH. A weak base will have a higher H+ concentration than a stronger base because it is less completely protonated than a stronger base and, therefore, more hydrogen ions remain in its solution. Given its greater H+ concentration, the formula yields a lower ...
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Perchlorate
A perchlorate is a chemical compound containing the perchlorate ion, . The majority of perchlorates are commercially produced salts. They are mainly used as oxidizers for pyrotechnic devices and to control static electricity in food packaging. Perchlorate contamination in food, water, and other parts of the environment has been studied in the U.S. because of harmful effects on human health. Perchlorate ions are somewhat toxic to the thyroid gland. Most perchlorates are colorless solids that are soluble in water. Four perchlorates are of primary commercial interest: ammonium perchlorate , perchloric acid , potassium perchlorate and sodium perchlorate . Perchlorate is the anion resulting from the dissociation of perchloric acid and its salts upon their dissolution in water. Many perchlorate salts are soluble in non-aqueous solutions. Production Perchlorate salts are produced industrially by the oxidation of aqueous solutions of sodium chlorate by electrolysis. This method is used ...
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Chlorate
The chlorate anion has the formula ClO3-. In this case, the chlorine atom is in the +5 oxidation state. "Chlorate" can also refer to chemical compounds containing this anion; chlorates are the salts of chloric acid. "Chlorate", when followed by a Roman numeral in parentheses, e.g. chlorate (VII), refers to a particular oxyanion of chlorine. As predicted by valence shell electron pair repulsion theory, chlorate anions have trigonal pyramidal structures. Chlorates are powerful oxidizers and should be kept away from organics or easily oxidized materials. Mixtures of chlorate salts with virtually any combustible material (sugar, sawdust, charcoal, organic solvents, metals, etc.) will readily deflagrate. Chlorates were once widely used in pyrotechnics for this reason, though their use has fallen due to their instability. Most pyrotechnic applications that formerly used chlorates now use the more stable perchlorates instead. Structure and bonding The chlorate ion cannot be satisf ...
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Chlorine Dioxide
Chlorine dioxide is a chemical compound with the formula ClO2 that exists as yellowish-green gas above 11 °C, a reddish-brown liquid between 11 °C and −59 °C, and as bright orange crystals below −59 °C. It is usually handled as an aqueous solution. It is also commonly used as a bleach. More recent developments have extended its applications in food processing and as a disinfectant. Structure and bonding The molecule ClO2 has an odd number of valence electrons, and therefore, it is a paramagnetic radical. It is an unusual "example of an odd-electron molecule which is stable towards dimerization" ( nitric oxide being another example). In 1933, Lawrence O. Brockway, a graduate student of Linus Pauling, proposed a structure that involved a three-electron bond and two single bonds. However, Pauling in his ''General Chemistry'' shows a double bond to one oxygen and a single bond plus a three-electron bond to the other. The valence bond structur ...
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Bleach
Bleach is the generic name for any chemical product that is used industrially or domestically to remove color (whitening) from a fabric or fiber or to clean or to remove stains in a process called bleaching. It often refers specifically, to a dilute solution of sodium hypochlorite, also called "liquid bleach". Many bleaches have broad spectrum bactericidal properties, making them useful for disinfecting and sterilizing. They are used in swimming pool sanitation to control bacteria, viruses, and algae, and in many places where sterile conditions are required. They are also used in many industrial processes, notably in the bleaching of wood pulp. Bleaches also have other minor uses like removing mildew, killing weeds, and increasing the longevity of cut flowers. Bleaches work by reacting with many colored organic compounds, such as natural pigments, and turning them into colorless ones. While most bleaches are oxidizing agents (chemicals that can remove electrons from other ...
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Hypochlorite
In chemistry, hypochlorite is an anion with the chemical formula ClO−. It combines with a number of cations to form hypochlorite salts. Common examples include sodium hypochlorite (household bleach) and calcium hypochlorite (a component of bleaching powder, swimming pool "chlorine"). The Cl-O distance in ClO− is 1.69 Å. The name can also refer to esters of hypochlorous acid, namely organic compounds with a ClO– moiety (chemistry), group covalent bond, covalently bound to the rest of the molecule. The principal example is tert-butyl hypochlorite, which is a useful chlorinating agent. Most hypochlorite salts are handled as aqueous solutions. Their primary applications are as bleaching, disinfection, and water treatment agents. They are also used in chemistry for Halogenation, chlorination and oxidation reactions. Reactions Acid reaction Acidification of hypochlorites generates hypochlorous acid, which exists in an equilibrium with chlorine. A high pH drives the reactio ...
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