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Chinese Red-headed Centipede
The Chinese red-headed centipede, also known as the Chinese red head, (''Scolopendra subspinipes mutilans'') is a centipede from East Asia and Australasia. It averages 20 cm (8 in) in length and lives in damp environments. In ancient Chinese traditions, this centipede is used for its healing properties. Putting a Chinese red head on a rash or other skin-disease is said to speed up the healing process. The roasted dry centipede is pulverized and used in Korea for the treatment of back pain, Boil, furuncles, and sores. ''S. s. mutilans'' is known for harbouring little aggression to other centipedes, a trait very rare amongst giant centipedes, and allows it to be kept communally. Antimicrobial activities of the identified compounds were reported against Gram-positive and Gram-negative bacteria, fungi, viruses, and parasites, that possibly explain centipede's survival in harsh and polluted environments. Females are incubator mothers, guarding the eggs by wrapping the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ludwig Carl Christian Koch
Ludwig Carl Christian Koch (8 November 1825 – 1 November 1908) was a German entomologist and arachnologist. He was born in Regensburg, Germany, and died in Nuremberg, Germany. He studied in Nuremberg, initially law, but then turned to medicine and science. From 1850, he practiced as a physician in the Wöhrd district of Nuremberg. He is considered among the four most influential scientists on insects and spiders in the second half of the 19th century. He wrote numerous works on the arachinoids of Europe, Siberia, and Australia. His work earned him worldwide reputation as "Spider Koch". Sometimes confused with his father Carl Ludwig Koch (1778–1857), another famous arachnologist, his name is abbreviated L.Koch on species descriptions; his father's name is abbreviated C.L.Koch Pierre Bonnet. ''Bibliographia araneorum,'' (1945) Les frères Doularoude (Toulouse). Works ''Die Arachniden Australiens'' (1871-1883), his major work on Australian spiders, was completed by Euge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metalloproteinase
A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis. Most metalloproteases require zinc, but some use cobalt. The metal ion is coordinated to the protein via three ligands. The ligands coordinating the metal ion can vary with histidine, glutamate, aspartate, lysine, and arginine. The fourth coordination position is taken up by a labile water molecule. Treatment with chelating agents such as EDTA leads to complete inactivation. EDTA is a metal chelator that removes zinc, which is essential for activity. They are also inhibited by the chelator orthophenanthroline. Classification There are two subgroups of metalloproteinases: * Exopeptidases, metalloexopeptidases ( EC number: 3.4.17). * Endopeptidases, metalloendopeptidases (3.4.24). Well known metalloendopeptidases include ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formyl Peptide Receptor 1
Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the ''formyl peptide receptor 1'' (''FPR1'') gene. This gene encodes a G protein-coupled receptor cell surface protein that binds and is activated by N-Formylmethionine-containing oligopeptides, particularly N-Formylmethionine-leucyl-phenylalanine (FMLP). FPR1 is prominently expressed by mammalian phagocytic and blood leukocyte cells where it functions to mediate these cells' responses to the N-formylmethionine-containing oligopeptides which are released by invading microorganisms and injured tissues. FPR1 directs these cells to sites of invading pathogens or disrupted tissues and then stimulates these cells to kill the pathogens or to remove tissue debris; as such, it is an important component of the innate immune system that operates in host defense and damage control. Hum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Signal-regulated Kinases
In molecular biology, extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens, activate the ERK pathway. The term, "extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase (MAPK), but has more recently been adopted for a specific subset of the mammalian MAPK family. In the MAPK/ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1/2 (below). Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2/SOS, but may also receive other si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemotaxis
Chemotaxis (from '' chemo-'' + '' taxis'') is the movement of an organism or entity in response to a chemical stimulus. Somatic cells, bacteria, and other single-cell or multicellular organisms direct their movements according to certain chemicals in their environment. This is important for bacteria to find food (e.g., glucose) by swimming toward the highest concentration of food molecules, or to flee from poisons (e.g., phenol). In multicellular organisms, chemotaxis is critical to early development (e.g., movement of sperm towards the egg during fertilization) and development (e.g., migration of neurons or lymphocytes) as well as in normal function and health (e.g., migration of leukocytes during injury or infection). In addition, it has been recognized that mechanisms that allow chemotaxis in animals can be subverted during cancer metastasis. The aberrant chemotaxis of leukocytes and lymphocytes also contribute to inflammatory diseases such as atherosclerosis, asthma, and arthr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
S180
S180 is a murine Sarcoma A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal ( connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sar ... cancer cell line. It has been commonly used in cancer research due to its rapid growth and proliferation in mice. The cell line was initially harvested from a soft tissue tumor in a Swiss mouse. References External linksCellosaurus entry for S180 Rodent cell lines {{cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitogen-activated Protein Kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis. MAP kinases are found in eukaryotes only, but they are fairly diverse and encountered in all animals, fungi and plants, and even in an array of unicellular eukaryotes. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). Discovery The first mitogen-activated protein kinase to be discovered was ERK1 ( MAPK3) in mammals. Since ERK1 and its close relative ERK2 ( MAPK1) are both involved in growth factor signaling, the family ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tiomesterone
Tiomesterone ( INN, JAN; thiomesterone (BAN); also known as 1α,7α-bis(acetylthio)-17α-methylandrost-4-en-17β-ol-3-one; developmental code StA 307; brand names Emdabol, Embadol, Emdabolin, and Protabol) is a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of testosterone Testosterone is the primary sex hormone and anabolic steroid in males. In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristi .... It was described in 1963. References Androgens and anabolic steroids Androstanes Hepatotoxins Thioesters {{genito-urinary-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PI3K/AKT/mTOR Pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. There are many known factors that enhance the PI3K/AKT pathway including EGF, shh, IGF-1, insulin, and CaM. Both leptin and insulin recruit PI3K signalling for metabolic regulation. The pathway is antagonized by various factors including PTEN, GSK3B, and HB9. In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation. This pathway is necessary, however, to promote growth and proliferation over differentiation of adult stem cells, neural s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medical practice drawn from traditional medicine in China. It has been described as "fraught with pseudoscience", with the majority of its treatments having no logical mechanism of action. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, literati theory and Confucian philosophy, herbal remedies, food, diet, exercise, medical specializations, and schools of thought. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selected elements of philosophy and practice and organized them into what they called "Chinese medicine" (''Zhongyi''). In the 1950s, the Chinese government sponsored the integration of Chinese and Western medicine, and in the Great Proletarian Cultural Revolution of the 1960s, promoted Chinese medicine as inexpens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scolopendra Negrocapitis
''Scolopendra'' (through Latin from Greek , ''skolopendra'') is a species-rich genus of large tropical centipedes of the family Scolopendridae. Description The genus ''Scolopendra'' contains many species of centipedes found across the world's tropics and warmer temperate areas. The species vary considerably in coloration and size. ''Scolopendra'' are mostly very large centipedes. The largest species found in tropical climates can exceed and are the largest living centipedes in the world. All ''Scolopendra'' species can deliver a painful bite, injecting venom through their forcipules, which are not fangs or other mouthparts; rather, these are modified legs on the first body segment. Ecology ''Scolopendra'' are active predators, feeding primarily on insects and other invertebrates. Larger specimens have been observed preying on frogs, tarantulas, lizards, birds, snakes, rodents, and even bats. Two southeast Asian species, '' S. cataracta'' and '' S. paradoxa'', are amphib ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scolopendra Multidens
''Scolopendra'' (through Latin from Greek , ''skolopendra'') is a species-rich genus of large tropical centipedes of the family Scolopendridae. Description The genus ''Scolopendra'' contains many species of centipedes found across the world's tropics and warmer temperate areas. The species vary considerably in coloration and size. ''Scolopendra'' are mostly very large centipedes. The largest species found in tropical climates can exceed and are the largest living centipedes in the world. All ''Scolopendra'' species can deliver a painful bite, injecting venom through their forcipules, which are not fangs or other mouthparts; rather, these are modified legs on the first body segment. Ecology ''Scolopendra'' are active predators, feeding primarily on insects and other invertebrates. Larger specimens have been observed preying on frogs, tarantulas, lizards, birds, snakes, rodents, and even bats. Two southeast Asian species, '' S. cataracta'' and '' S. paradoxa'', are amphibiou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
