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Chicken As Biological Research Model
Chickens (''Gallus gallus domesticus'') and their eggs have been used extensively as research models throughout the history of biology. Today they continue to serve as an important model for normal human biology as well as pathological disease processes. History Chicken embryos as a research model Human fascination with the chicken and its egg are so deeply rooted in history that it is hard to say exactly when avian exploration began. As early as 1400 BCE, ancient Egyptians artificially incubated chicken eggs to propagate their food supply. The developing chicken in the egg first appears in written history after catching the attention of the famous Greek philosopher, Aristotle, around 350 BCE. As Aristotle opened chicken eggs at various time points of incubation, he noted how the organism changed over time. Through his writing of '' Historia Animalium'', he introduced some of the earliest studies of embryology based on his observations of the chicken in the egg. Aristotle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chicken
The chicken (''Gallus gallus domesticus'') is a domesticated junglefowl species, with attributes of wild species such as the grey and the Ceylon junglefowl that are originally from Southeastern Asia. Rooster or cock is a term for an adult male bird, and a younger male may be called a cockerel. A male that has been castrated is a capon. An adult female bird is called a hen and a sexually immature female is called a pullet. Humans now keep chickens primarily as a source of food (consuming both their meat and eggs) and as pets. Traditionally they were also bred for cockfighting, which is still practiced in some places. Chickens are one of the most common and widespread domestic animals, with a total population of 23.7 billion , up from more than 19 billion in 2011. There are more chickens in the world than any other bird. There are numerous cultural references to chickens – in myth, folklore and religion, and in language and literature. Genetic studies have pointed to mult ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Goodpasture
Ernest William Goodpasture (October 17, 1886 – September 20, 1960) was an American pathologist and physician. Goodpasture advanced the scientific understanding of the pathogenesis of infectious diseases, parasitism, and a variety of rickettsial and viral infections. Together with colleagues at Vanderbilt University, he invented methods for growing viruses and rickettsiae in chicken embryos and fertilized chicken eggs. This enabled the development of vaccines against influenza, chicken pox, smallpox, yellow fever, typhus, Rocky mountain spotted fever, and other diseases. He also described Goodpasture syndrome.Valentini, Rudolph PPediatric Anti-GBM Disease (Goodpasture Syndrome). Accessed 8-28-2009. Education and professional career Goodpasture was born in Clarksville, Tennessee, in 1886. He received his B.A. from Vanderbilt University in 1908. In 1912, Goodpasture graduated from Johns Hopkins School of Medicine with an M.D. degree. There, under professors William H. Welch a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation and programmed cell death, in the form of apoptosis, is maintained to ensure the integrity of tissues and organs. According to the prevailing accepted theory of carcinogenesis, the somatic mutation theory, mutations in DNA and epimutations that lead to cancer disrupt these orderly processes by interfering with the programming regulating the processes, upsetting the normal balance between proliferation and cell death. This results in uncontrolled cell division and the evolution of those cells by natural selection in the body. Only certain mutations lead to cancer w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncovirus
An oncovirus or oncogenic virus is a virus that can cause cancer. This term originated from studies of acutely transforming retroviruses in the 1950–60s, when the term "oncornaviruses" was used to denote their RNA virus origin. With the letters "RNA" removed, it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with "tumor virus" or "cancer virus". The vast majority of human and animal viruses do not cause cancer, probably because of longstanding co-evolution between the virus and its host. Oncoviruses have been important not only in epidemiology, but also in investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research on Cancer estimated that in 2002, infection caused 17.8% of human cancers, with 11.9% caused by one of seven viruses. A 2020 study of 2,658 samples from 38 different types of cancer found that 16% were associated with a virus. These cancers m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chorioallantoic Membrane
The Chorioallantoic Membrane (CAM), also known as the chorioallantois, is a highly vascularized membrane found in the eggs of certain amniotes like birds and reptiles. It is formed by the fusion of the mesodermal layers of two extra-embryonic membranes – the chorion and the allantois. It is the avian homologue of the mammalian placenta. It is the outermost extra-embryonic membrane which lines the non-vascular egg shell membrane. Structure The chorioallantoic membrane is composed of three layers. The first is the chorionic epithelium that is the external layer present immediately below the shell membrane. It consist of epithelial cells that arise from chorionic ectoderm. The second is the intermediate mesodermal layer that consists of mesenchymal tissue formed by the fusion of the mesodermal layer of the chorion and the mesodermal layer of the allantois. This layer is highly vascularized and rich in stromal components. The third is the allantoic epithelium that consists of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bruce Glick
The English language name Bruce arrived in Scotland with the Normans, from the place name Brix, Manche in Normandy, France, meaning "the willowlands". Initially promulgated via the descendants of king Robert the Bruce (1274−1329), it has been a Scottish surname since medieval times; it is now a common given name. The variant ''Lebrix'' and ''Le Brix'' are French variations of the surname. Actors * Bruce Bennett (1906–2007), American actor and athlete * Bruce Boxleitner (born 1950), American actor * Bruce Campbell (born 1958), American actor, director, writer, producer and author * Bruce Davison (born 1946), American actor and director * Bruce Dern (born 1936), American actor * Bruce Gray (1936–2017), American-Canadian actor * Bruce Greenwood (born 1956), Canadian actor and musician * Bruce Herbelin-Earle (born 1998), English-French actor and model * Bruce Jones (born 1953), English actor * Bruce Kirby (1925–2021), American actor * Bruce Lee (1940–1973), martial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bursa Of Fabricius
In birds, the bursa of Fabricius (Latin: ''bursa cloacalis'' or ''bursa fabricii'') is the site of hematopoiesis. It is a specialized organ that, as first demonstrated by Bruce Glick and later by Max Dale Cooper and Robert Good, is necessary for B cell (part of the immune system) development in birds. Mammals generally do not have an equivalent organ; the bone marrow is often the site of both hematopoiesis and B cell development. The bursa is present in the cloaca of birds and is named after Hieronymus Fabricius, who described it in 1621. Description The bursa is an epithelial and lymphoid organ that is found only in birds. The bursa develops as a dorsal diverticulum of the proctadael region of the cloaca. The luminal (interior) surface of the bursa is plicated with as many as 15 primary and 7 secondary plicae or folds. These plicae have hundreds of bursal follicles containing follicle-associated epithelial cells, lymphocytes, macrophages, and plasma cells. Lymphoid stem ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harold Varmus
Harold Eliot Varmus (born December 18, 1939) is an American Nobel Prize-winning scientist. He is currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine and a senior associate at the New York Genome Center. He was a co-recipient (along with J. Michael Bishop) of the 1989 Nobel Prize in Physiology or Medicine for discovery of the cellular origin of retroviral oncogenes. He was also the director of the National Institutes of Health from 1993 to 1999 and the 14th Director of the National Cancer Institute from 2010 to 2015, a post to which he was appointed by President Barack Obama. Early life and education Varmus was born to Beatrice, a social service worker, and Frank Varmus, a physician, Jewish parents of Eastern European descent, in Oceanside, New York.''Les Prix Nobel.'' The Nobel Prizes 1989, Editor Tore Frängsmyr, Nobel Foundation, Stockholm, 1990. In 1957, he graduated from Freeport High School in Freeport, New York, and enrolled at Amherst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steve Martin
Stephen Glenn Martin (born August 14, 1945) is an American actor, comedian, writer, producer, and musician. He has won five Grammy Awards, a Primetime Emmy Award, and was awarded an Honorary Academy Award in 2013. Additionally, he was nominated for two Tony Awards for his musical '' Bright Star'' in 2016. Among many honors, he has received the Mark Twain Prize for American Humor, the Kennedy Center Honors, and an AFI Life Achievement Award. In 2004, Comedy Central ranked Martin at sixth place in a list of the 100 greatest stand-up comics. ''The Guardian'' named him one of the best actors never to have received an Academy Award nomination. Martin came to public notice in the 1960s as a writer for ''The Smothers Brothers Comedy Hour'', for which he won a Primetime Emmy Award in 1969, and later as a frequent host on ''Saturday Night Live''. In the 1970s, Martin performed his offbeat, absurdist comedy routines before sold-out theaters on national tours. Since the 1980s, having ret ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peyton Rous
Francis Peyton Rous () (October 5, 1879 – February 16, 1970) was an American pathologist at the Rockefeller University known for his works in oncoviruses, blood transfusion and physiology of digestion. A medical graduate from the Johns Hopkins University, he was discouraged to become a practicing physician due to severe tuberculosis. After three years of working as an instructor of pathology at the University of Michigan, he became dedicated researcher at the Rockefeller Institute for Medical Research for the rest of his career. His discovery in 1911 that a chicken tumor was caused by a virus (later named Rous sarcoma virus) led to more discoveries and understanding of the role of viruses in the development of certain types of cancer. He was awarded a Nobel Prize in Physiology or Medicine for his work in 1966, 55 years after his initial discovery and he remains the oldest recipient of the Nobel Prize in Medicine or Physiology. He and Joseph R. Turner studied methods to make ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louis Pasteur
Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named after him. His research in chemistry led to remarkable breakthroughs in the understanding of the causes and preventions of diseases, which laid down the foundations of hygiene, public health and much of modern medicine. His works are credited to saving millions of lives through the developments of vaccines for rabies and anthrax. He is regarded as one of the founders of modern bacteriology and has been honored as the "father of bacteriology" and the "father of microbiology" (together with Robert Koch; the latter epithet also attributed to Antonie van Leeuwenhoek). Pasteur was responsible for disproving the doctrine of spontaneous generation. Under the auspices of the French Academy of Sciences, his experiment demonstrated that in sterilized ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholera
Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This may result in sunken eyes, cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish. Symptoms start two hours to five days after exposure. Cholera is caused by a number of types of ''Vibrio cholerae'', with some types producing more severe disease than others. It is spread mostly by unsafe water and unsafe food that has been contaminated with human feces containing the bacteria. Undercooked shellfish is a common source. Humans are the only known host for the bacteria. Risk factors for the disease include poor sanitation, not enough clea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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