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Checkpoint Alpha
Checkpoint may refer to: Places * Border checkpoint, a place on the land border between two states where travellers and/or goods are inspected * Security checkpoint, erected and enforced within contiguous areas under military or paramilitary control * Random checkpoint, a police or military checkpoint that is moved to various locations * Weigh station, a highway checkpoint to inspect vehicular weights Arts and entertainment * Checkpoint (G.I. Joe), a fictional character in the G.I. Joe universe * Checkpoint (''Transformers''), two fictional characters in the ''Transformers'' universes * ''Checkpoint'' (novel), a 2004 novel by Nicholson Baker * ''Checkpoint'' (journal), 1969-1974 * ''Checkpoint'' (pinball), a 1991 pinball machine released by Data East * Checkpoint (video gaming), locations in a video game where a player character respawns after death * CheckPoint, a web series by sketch comedy group LoadingReadyRun Film and television * ''Checkpoint'' (1956 film), a British c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Border Checkpoint
A border checkpoint is a location on an international border where travelers or goods are inspected and allowed (or denied) passage through. Authorization often is required to enter a country through its borders. Access-controlled borders often have a limited number of checkpoints where they can be crossed without legal sanctions. Arrangements or treaties may be formed to allow or mandate less restrained crossings (e.g. the Schengen Agreement). Land border checkpoints (land ports of entry) can be contrasted with the customs and immigration facilities at seaports, international airports, and other ports of entry. Checkpoints generally serve two purposes: * To prevent entrance of individuals who are either undesirable (e.g. criminals or others who pose threats) or simply unauthorized to enter. * To prevent entrance of goods that are illegal or subject to restriction, or to collect tariffs. Checkpoints are usually staffed by a uniformed service (sometimes referred to as customs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Cycle Checkpoint
Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression. Each checkpoint serves as a potential termination point along the cell cycle, during which the conditions of the cell are assessed, with progression through the various phases of the cell cycle occurring only when favorable conditions are met. There are many checkpoints in the cell cycle, but the three major ones are: the G1 checkpoint, also known as the Start or restriction checkpoint or Major Checkpoint; the G2/M checkpoint; and the metaphase-to-anaphase transition, also known as the spindle checkpoint. Progression through these checkpoints is largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at each stage of the cell cycle to control the specific events that occur therein. Background All living organisms are the products of repeated rounds of cell growth and division ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Control Point (orienteering)
A control point (CP, also control and checkpoint) is a marked waypoint used in orienteering and related sports such as rogaining and adventure racing. It is located in the competition area; marked both on an orienteering map and in the terrain, and described on a control description sheet. The control point must be identifiable on the map and on the ground. A control point has three components: a high visibility item, known as a flag or kite; an identifier, known as a control code; and a recording mechanism for contestants to record proof that they visited the control point. The control point is usually temporary, except on a permanent orienteering course. For events held under International Orienteering Federation (IOF) rules the kite has a triangular form with each face being about 30 cm x 30 cm and coloured white and orange. Most national governing bodies, and related sports use the same design. The earlier specification used white and red. The location of co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomson Reuters
Thomson Reuters Corporation ( ) is a Canadian multinational media conglomerate. The company was founded in Toronto, Ontario, Canada, where it is headquartered at the Bay Adelaide Centre. Thomson Reuters was created by the Thomson Corporation's purchase of the British company Reuters Group in April 2008. It is majority-owned by The Woodbridge Company, a holding company for the Thomson family. History Thomson Corporation The forerunner of the Thomson company was founded by Roy Thomson in 1934 in Ontario, as the publisher of ''The Timmins Daily Press''. In 1953, Thomson acquired the ''Scotsman'' newspaper and moved to Scotland the following year. He consolidated his media position in Scotland in 1957, when he won the franchise for Scottish Television. In 1959, he bought the Kemsley Group, a purchase that eventually gave him control of the '' Sunday Times''. He separately acquired the ''Times'' in 1967. He moved into the airline business in 1965, when he acquired Britanni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Check Point
Check Point is an American-Israeli multinational provider of software and combined hardware and software products for IT security, including network security, endpoint security, cloud security, mobile security, data security and security management. , the company has approximately 6,000 employees worldwide. Headquartered in Tel Aviv, Israel and San Carlos, California, the company has development centers in Israel and Belarus and previously held in United States (ZoneAlarm), Sweden (former Protect Data development centre) following acquisitions of companies who owned these centers. The company has offices in over 70 locations worldwide including main offices in North America, 10 in the United States (including in San Carlos, California and Dallas, Texas), 4 in Canada (including Ottawa, Ontario) as well as in Europe (London, Paris, Munich, Madrid) and in Asia Pacific (Singapore, Japan, Bengaluru, Sydney) . History Check Point was established in Ramat Gan, Israel in 1993, by Gil Sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Checkpoint (rapid HIV Testing Facility)
Checkpoint was the name of the first rapid HIV testing facility in the Netherlands. This project, run on a voluntary basis, was based in Amsterdam. From 21 June 2002 until its closure on 27 June 2008 almost 5000 people opted for a Checkpoint HIV test. The rapid HIV testing employed by Checkpoint was for the whole of its existence unique in the Netherlands, because it was at that time not used by the various local health authorities. Such authorities and physicians employed the regular HIV antibody test and clients had to wait 1 or 2 weeks for the result. When an increasing number of local health authorities began using the rapid HIV test, Checkpoint had served its purpose and could be closed down. The rapid HIV test enabled a reliable outcome to be generated within 15 to 20 minutes, which in practice lowered the threshold for such testing. Because in this way more people opted for testing, more HIV-positive people could be reached. A clear advantage is that the diagnosis is ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Checkpoint Systems
Checkpoint Systems is an American company that specializes in loss prevention and merchandise visibility for retail companies. It makes products that allow retailers to check inventory, quicken the replenishment cycle, prevent out-of-stocks and reduce theft. Checkpoint offers Electronic Article Surveillance (EAS) radio frequency solutions for retail, high-theft and loss-prevention solutions, RFID hardware, software, and labeling capabilities. History The checkpoint was invented in the United States during the 1960s, when Peter Stern, who was president of the Board of Library Directors in the city of Philadelphia, was deeply concerned about the widespread theft of books from public libraries. He was the leader of a team of researchers working at a privately held converter of paperboard and paper, and believed this was a problem his team could tackle and that a system could be developed to prevent books from being stolen. Thus the CHECKPOINT system was developed and patented ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transaction Checkpoint
Transaction processing is a way of computing that divides work into individual, indivisible operations, called transactions. A transaction processing system (TPS) is a software system, or software/ hardware combination, that supports transaction processing. History The first transaction processing system was SABRE, made by IBM for American Airlines, which became operational in 1964. Designed to process up to 83,000 transactions a day, the system ran on two IBM 7090 computers. SABRE was migrated to IBM System/360 computers in 1972, and became an IBM product first as '' Airline control Program (ACP)'' and later as '' Transaction Processing Facility (TPF)''. In addition to airlines TPF is used by large banks, credit card companies, and hotel chains. The Hewlett-Packard NonStop system (formerly Tandem NonStop) was a hardware and software system designed for ''Online Transaction Processing (OLTP)'' introduced in 1976. The systems were designed for transaction processing and prov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Application Checkpointing
Checkpointing is a technique that provides fault tolerance for computing systems. It basically consists of saving a snapshot of the application's state, so that applications can restart from that point in case of failure. This is particularly important for long running applications that are executed in failure-prone computing systems. Checkpointing in distributed systems In the distributed computing environment, checkpointing is a technique that helps tolerate failures that otherwise would force long-running application to restart from the beginning. The most basic way to implement checkpointing, is to stop the application, copy all the required data from the memory to reliable storage (e.g., parallel file system) and then continue with the execution. In case of failure, when the application restarts, it does not need to start from scratch. Rather, it will read the latest state ("the checkpoint") from the stable storage and execute from that. While there is ongoing debate on wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Checkpoint
Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. However, some cancers can protect themselves from attack by stimulating immune checkpoint targets. Inhibitory checkpoint molecules are targets for cancer immunotherapy due to their potential for use in multiple types of cancers. Currently approved checkpoint inhibitors block CTLA4 and PD-1 and PD-L1. For the related basic science discoveries, James P. Allison and Tasuku Honjo won the Tang Prize in Biopharmaceutical Science and the Nobel Prize in Physiology or Medicine in 2018. Stimulatory checkpoint molecules Four stimulatory checkpoint molecules are members of the tumor necrosis factor (TNF) receptor superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong to the B7-CD28 superfamily—CD28 itself and ICOS. * CD27: This molecule supports antigen-specific ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spindle Checkpoint
The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during mitosis or meiosis that prevents the separation of the duplicated chromosomes (anaphase) until each chromosome is properly attached to the spindle. To achieve proper segregation, the two kinetochores on the sister chromatids must be attached to opposite spindle poles (bipolar orientation). Only this pattern of attachment will ensure that each daughter cell receives one copy of the chromosome. The defining biochemical feature of this checkpoint is the stimulation of the anaphase-promoting complex by M-phase cyclin-CDK complexes, which in turn causes the proteolytic destruction of cyclins and proteins that hold the sister chromatids together. Overview and importance The beginning of metaphase is characterized by the connection of the microtubules to the kinetochores of the chrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
G2-M DNA Damage Checkpoint
The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired. Cells with a defective G2-M checkpoint will undergo apoptosis or death after cell division if they enter the M phase before repairing their DNA. The defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring the cell to metaphase. Cyclin B-CDK 1 activity The cell cycle is driven by proteins called cyclin dependent kinases that associate with cyclin regulatory proteins at different checkpoints of the cell cycle. Different phases of the cell cycle experience activation and/or deactivation of specific cyclin-CDK complexes. CyclinB-CDK1 activity is specific to the G2/M checkpoint. Accumulation of cyclin B increases the activity of the cyclin dependent kinase Cdk1 hum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
