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Charles Enrique Dent
Charles Enrique Dent, (25 August 1911 – 19 September 1976) was a British professor of human metabolism at University College, London. After studying chemistry at Imperial College London, he gained a PhD for his work on copper phthalocyanin, then worked for ICI Dyestuffs Group in Manchester and also studied secret writing, which he later made use of during the Second World War. He completed his medical studies in 1944. The following year, he was sent by the Medical Research Council to the recently liberated concentration camp at Belsen together with Janet Vaughan and Rosalind Pitt-Rivers, to study if starvation could be treated with protein hydrolysates. From 1946, his career focused on several inborn errors of metabolism. He was appointed a Commander of the Order of the British Empire in the 1976 New Year Honours Early life He was born in Burgos, Spain, son of Leeds-born Frankland Dent, a chemist, and his Spanish wife Carmen de Mira y Perceval, who met while his father was wo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University College, London
, mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = £1.544 billion (2019/20) , chancellor = Anne, Princess Royal(as Chancellor of the University of London) , provost = Michael Spence , head_label = Chair of the council , head = Victor L. L. Chu , free_label = Visitor , free = Sir Geoffrey Vos , academic_staff = 9,100 (2020/21) , administrative_staff = 5,855 (2020/21) , students = () , undergrad = () , postgrad = () , coordinates = , campus = Urban , city = London, England , affiliations = , colours = Purple and blue celeste , nickname ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dunkirk Evacuation
The Dunkirk evacuation, codenamed Operation Dynamo and also known as the Miracle of Dunkirk, or just Dunkirk, was the evacuation of more than 338,000 Allied soldiers during the Second World War from the beaches and harbour of Dunkirk, in the north of France, between 26 May and 4 June 1940. The operation commenced after large numbers of Belgian, British, and French troops were cut off and surrounded by German troops during the six-week Battle of France. In a speech to the House of Commons, British Prime Minister Winston Churchill called this "a colossal military disaster", saying "the whole root and core and brain of the British Army" had been stranded at Dunkirk and seemed about to perish or be captured. In his "We shall fight on the beaches" speech on 4 June, he hailed their rescue as a "miracle of deliverance". After Germany invaded Poland in September 1939, France and the British Empire declared war on Germany and imposed an economic blockade. The British Expeditionary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dent's Disease
Dent's disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. "Dent's disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with kidney failure, X-linked recessive hypophosphatemic rickets, and both Japanese and idiopathic low-molecular-weight proteinuria. About 60% of patients have mutations in the ''CLCN5'' gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the ''OCRL1'' gene (Dent 2). Signs and symptoms Dent's disease often produces the following signs and symptoms: * Extreme thirst combined with dehydration, which leads to frequent urination * Nephrolithiasis (kidney stones) * Hypercal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oliver Wrong
Professor Oliver Murray Wrong (7 February 1925 – 24 February 2012) was an eminent academic nephrologist (kidney specialist) and one of the founders of the speciality in the United Kingdom. From a background as a "salt and water" physician, he made detailed clinical observations and scientifically imaginative connections which were the basis of numerous advances in the molecular biology of the human kidney. Wrong himself contributed to much of the molecular work after his own "retirement". He dictated amendments to his final paper during his final illness in his own teaching hospital, University College Hospital (UCH), London. Though academic in his leanings, he was a compassionate physician who established a warm rapport with patients (though not with his students), a link he regarded as the keystone of his research. He belonged to a generation of idealistic young doctors responsible for the establishment of the UK's National Health Service in the post-War years. Background ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homocystinuria
Homocystinuria or HCU is an inherited disorder of the metabolism of the amino acid methionine due to a deficiency of cystathionine beta synthase or methionine synthase. It is an inherited autosomal recessive trait, which means a child needs to inherit a copy of the defective gene from both parents to be affected. Symptoms of homocystinuria can also be caused by a deficiency of vitamins B6, B12, or folate. Signs and symptoms This defect leads to a multi-systemic disorder of the connective tissue, muscles, central nervous system (CNS), and cardiovascular system. Homocystinuria represents a group of hereditary metabolic disorders characterized by an accumulation of the amino acid homocysteine in the serum and an increased excretion of homocysteine in the urine. Infants appear to be normal and early symptoms, if any are present, are vague. Signs and symptoms of homocystinuria that may be seen include the following: Cause It is usually caused by the deficiency of the enzyme cystathi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Argininosuccinic Aciduria
Argininosuccinic aciduria is an inherited disorder that causes the accumulation of argininosuccinic acid (also known as "ASA") in the blood and urine. Some patients may also have an elevation of ammonia, a toxic chemical, which can affect the nervous system. Argininosuccinic aciduria may become evident in the first few days of life because of high blood ammonia, or later in life presenting with "sparse" or "brittle" hair, developmental delay, and tremors. An infant with argininosuccinic aciduria may seem lethargic or be unwilling to eat, have poorly controlled breathing rate or body temperature, experience seizures or unusual body movements, or go into a coma. Complications from argininosuccinic aciduria may include developmental delay and mental retardation. Progressive liver damage, skin lesions, and brittle hair may also be seen. Immediate treatment and lifelong management (following a strict diet and using appropriate supplements) may prevent many of these complications. Occas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hartnup Disease
Hartnup disease (also known as "pellagra-like dermatosis" and "Hartnup disorder") is an autosomal recessive metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin). Niacin is a precursor to nicotinamide, a necessary component of NAD+. The causative gene, ''SLC6A19'', is located on chromosome 5. It is named after the British family, Hartnup, who had this disease. Signs and symptoms Hartnup disease manifests during infancy with variable clinical presentation: failure to thrive, photosensitivity, intermittent ataxia, nystagmus, and tremor. Nicotinamide is necessary for neutral amino acid transporter production in the proximal renal tubules found in the kidney, and intestinal mucosal cells found in the small intestine. Therefore, a symptom stemming from this disorder results in increased amounts of amino acids in the urine. Pellagra, a similar condition, is also caused b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fanconi Syndrome
Fanconi syndrome or Fanconi's syndrome (, ) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying congenital or acquired diseases, by toxicity (for example, from toxic heavy metals), or by adverse drug reactions. It results in various small molecules of metabolism being passed into the urine instead of being reabsorbed from the tubular fluid (for example, glucose, amino acids, uric acid, phosphate, and bicarbonate). Fanconi syndrome affects the proximal tubules, namely, the proximal convoluted tubule (PCT), which is the first part of the tubule to process fluid after it is filtered through the glomerulus, and the proximal straight tubule (pars recta), which leads to the descending limb of loop of Henle. Different forms of Fanconi syndrome can affect different functions of the proximal tubule, and result in different complications. The loss of bicarbonate results in type 2 or proximal renal tubular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harold Himsworth
Sir Harold Percival (Harry) Himsworth, KCB, FRS (19 May 1905 – 1 November 1993) was a British scientist, best known for his medical research on diabetes mellitus. Early life He was born in Huddersfield, West Yorkshire, the son of Joseph Arnold Himsworth and Amy Eliza Barraclough. He was educated at the local Spring Grove School and King James's Grammar School, Almondbury. He married Charlotte Gray in 1932: they had two sons. Medical career He studied medicine at the University of London and trained in University College Hospital (UCH). His early involvement in medical research (especially of diabetes and later of liver disease) would lead to an important 1936 paper in The Lancet, distinguishing the two main types of diabetes. He delivered the Goulstonian Lecture at the Royal College of Physicians in 1939 entitled ''Mechanism of diabetes mellitus'' He was appointed Professor of Medicine at the University of London and the Secretary of the Medical Research Council (MRC) f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University College Hospital
University College Hospital (UCH) is a teaching hospital in the Fitzrovia area of the London Borough of Camden, England. The hospital, which was founded as the North London Hospital in 1834, is closely associated with University College London (UCL), whose main campus is situated next door. The hospital is part of the University College London Hospitals NHS Foundation Trust The hospital is on the south side of Euston Road and its tower faces Euston Square tube station on the east side. Warren Street tube station lies immediately west and the major Euston terminus station is beyond 200 metres east, just beyond Euston Square Gardens. History In 1826 the London University began emphasising the importance of having medical schools attached to hospitals. Before the hospital opened, only Oxford and Cambridge universities offered medical degrees, and as a consequence relatively few doctors actually had degrees. The hospital was founded as the North London Hospital in 1834 in order t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
