Charles Best (medical Scientist)
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Charles Best (medical Scientist)
Charles Herbert Best (February 27, 1899 – March 31, 1978) was an American-Canadian medical scientist and one of the co-discoverers of insulin. Biography Born in West Pembroke, Maine on February 27, 1899 to Luella Fisher and Herbert Huestis Best, Canadian born physician from Nova Scotia. Best grew up in Pembroke before going to Toronto, Ontario to study medicine in 1915. Best married Margaret Hooper Mahon in Toronto in 1924 and they had two sons. One son, Henry Best was a well-regarded historian who later became president of Laurentian University in Sudbury, Ontario. Best's other son was Charles Alexander Best, a Canadian politician and geneticist. Best is the grandfather of Susan MacTavish Best. His father, Herbert Best, was a doctor in a small Maine town with a limited economy based mostly on sardine-packing. His mother, Lulu Newcomb, later Lulu Best, who sang soprano, accompanying herself on organ and piano, was in demand as a performer at funerals and weddings. By the ...
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Pembroke, Maine
Pembroke is a town in Washington County, Maine, United States. The population was 788 at the 2020 census. The town is home to a reversing falls on Mahar's Point. History Called ''Pennamaquan'' by the Passamaquoddy Indians, the area was settled about 1774 as part of Dennysville. It was set off and incorporated on February 4, 1832 by the legislature, which named it after Pembroke in Wales, a community with a history of wooden shipbuilding stretching back to the Middle Ages. With one of the finest harbors in Maine, Pembroke too became a shipbuilding center. Vessels were constructed here as early as 1825. By 1859, when the population was 1,712, there were seven shipyards operating. Most schooners constructed here were used either by the coasting trade or fisheries. Pembroke also had a stone factory, three sawmills, one gristmill, four shingle mills and four lath machines. Near the head of tide stood the Pembroke Iron Company, established in 1832 and by 1856 producing almost ...
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Susan MacTavish Best
Susan MacTavish Best is the founder and CEO of Living MacTavish, a lifestyle business. She was previously the founder of Best Public Relations. She has become known for hosting salon-style dinner parties in San Francisco and New York. Early life and education MacTavish Best's mother is Laurie MacTavish Best and her father is the Canadian scientist and politician Charles Alexander Best. She is the granddaughter of Charles Best, the co-discoverer of insulin. She attended St Leonards boarding school in St Andrews, Fife. She graduated from Hamilton College with a bachelor's degree in History. She spent one year at Oxford University. Career MacTavish Best created and edited ''POSTHOC'', an online guide to San Francisco, after studying at night school at San Francisco State University’s Multimedia Center. MacTavish Best founded Best Public Relations in 1998. The company has focused on working with startups, and has worked with clients such as Craigslist, Esurance and Playf ...
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Nobel Foundation
The Nobel Foundation ( sv, Nobelstiftelsen) is a private institution founded on 29 June 1900 to manage the finances and administration of the Nobel Prizes. The foundation is based on the last will of Alfred Nobel, the inventor of dynamite. It also holds Nobel Symposia on important breakthroughs in science and topics of cultural or social significance. History , born on 21 October 1833 in Stockholm Sweden, was a chemist, engineer, innovator, armaments manufacturer and the inventor of dynamite. He owned Bofors, a major armaments manufacturer, which he had redirected from its original business as an iron and steel mill. Nobel held 355 different patents, dynamite being the most famous. Nobel amassed a sizeable personal fortune during his lifetime, thanks mostly to this invention. In 1896 Nobel died of a stroke in his villa in San Remo, Italy where he had lived his final years.AFP"Alfred Nobel's last will and testament", '' The Local''(5 October 2009): accessed 14 January 2009. ...
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Nobel Prize In Medicine
The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according to Alfred Nobel's 1895 will, are awarded "to those who, during the preceding year, have conferred the greatest benefit to humankind". Nobel Prizes are awarded in the fields of Physics, Chemistry, Physiology or Medicine, Literature, and Peace. The Nobel Prize is presented annually on the anniversary of Alfred Nobel's death, 10 December. As of 2022, 114 Nobel Prizes in Physiology or Medicine have been awarded to 226 laureates, 214 men and 12 women. The first one was awarded in 1901 to the German physiologist, Emil von Behring, for his work on serum therapy and the development of a vaccine against diphtheria. The first woman to receive the Nobel Prize in Physiology or Medicine, Gerty Cori, received it in 1947 for her role in elucidating the ...
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John James Richard Macleod
John James Rickard Macleod (6 September 1876 – 16 March 1935) was a Scottish biochemist and physiologist. He devoted his career to diverse topics in physiology and biochemistry, but was chiefly interested in carbohydrate metabolism. He is noted for his role in the discovery and isolation of insulin during his tenure as a lecturer at the University of Toronto, for which he and Frederick Banting received the 1923 Nobel prize in Physiology or Medicine. Awarding the prize to Macleod was controversial at the time, because according to Banting's version of events, Macleod's role in the discovery was negligible. It was not until decades after the events that an independent review acknowledged a far greater role than was attributed to him at first. Biography Macleod was born in Clunie, near Dunkeld in Perthshire. Soon after he was born, his father Robert Macleod, a clergyman, was transferred to Aberdeen, where John attended Aberdeen Grammar School and enrolled in the study of m ...
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Leonard Thompson (diabetic)
Leonard Thompson (17 July 1908 – 20 April 1935) is the first person to have received an injection of insulin as a treatment for Type 1 diabetes. Biography Thompson was first treated at SickKids hospital before being transferred to the care of physicians Andrew Almon Fletcher, Duncan Archibald Graham, and Walter Ruggles Campbell. Thompson received his first injection in Toronto, Ontario, on 11 January 1922, at 13 years of age. The first injection had an apparent impurity which was the likely cause for the allergic reaction he displayed. After a refined process was developed by James Collip to improve the canine pancreas extract, the second dosage was successfully delivered to the young patient 12 days after the first. Thompson showed signs of improved health and went on to live 13 more years taking doses of insulin, before dying of pneumonia at age 26. Until insulin was made clinically available, a diagnosis of Type 1 diabetes was a death sentence, more or less quickly (usu ...
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James Collip
James Bertram Collip (November 20, 1892 – June 19, 1965) was a Canadian biochemist who was part of the Toronto group which isolated insulin. He served as the Chair of the Department of Biochemistry at McGill University from 1928–1941 and Dean of Medicine at the University of Western Ontario from 1947–1961, where he was a charter member of The Kappa Alpha Society. Education Born in Belleville, Ontario, he enrolled at Trinity College at the University of Toronto at the age of 15, and studied physiology and biochemistry. He obtained a Ph.D. in Biochemistry from the same university in 1916. Career In 1915, at the age of 22, Collip accepted a lecturing position in Edmonton in the Department of Physiology at the University of Alberta Faculty of Medicine, shortly before completing his doctorate. He fulfilled the role for 7 years, eventually rising to the position of Professor and Head of the Department of Biochemistry in 1922. His research at the time was mainly focused on ...
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John James Rickard Macleod
John James Rickard Macleod (6 September 1876 – 16 March 1935) was a Scottish biochemist and physiologist. He devoted his career to diverse topics in physiology and biochemistry, but was chiefly interested in carbohydrate metabolism. He is noted for his role in the discovery and isolation of insulin during his tenure as a lecturer at the University of Toronto, for which he and Frederick Banting received the 1923 Nobel prize in Physiology or Medicine. Awarding the prize to Macleod was controversial at the time, because according to Banting's version of events, Macleod's role in the discovery was negligible. It was not until decades after the events that an independent review acknowledged a far greater role than was attributed to him at first. Biography Macleod was born in Clunie, near Dunkeld in Perthshire. Soon after he was born, his father Robert Macleod, a clergyman, was transferred to Aberdeen, where John attended Aberdeen Grammar School and enrolled in the study of med ...
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Diabetes
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ...
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Obituary Notices Of Fellows Of The Royal Society
The ''Biographical Memoirs of Fellows of the Royal Society'' is an academic journal on the history of science published annually by the Royal Society. It publishes obituaries of Fellows of the Royal Society. It was established in 1932 as ''Obituary Notices of Fellows of the Royal Society'' and obtained its current title in 1955, with volume numbering restarting at 1. Prior to 1932, obituaries were published in the ''Proceedings of the Royal Society''. The memoirs are a significant historical record and most include a full bibliography of works by the subjects. The memoirs are often written by a scientist of the next generation, often one of the subject's own former students, or a close colleague. In many cases the author is also a Fellow. Notable biographies published in this journal include Albert Einstein, Alan Turing, Bertrand Russell, Claude Shannon, Clement Attlee, Ernst Mayr, and Erwin Schrödinger. Each year around 40 to 50 memoirs of deceased Fellows of the Royal Society ...
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Frederick Banting
Sir Frederick Grant Banting (November 14, 1891 – February 21, 1941) was a Canadian medical scientist, physician, painter, and Nobel laureate noted as the co-discoverer of insulin and its therapeutic potential. In 1923, Banting and John Macleod received the Nobel Prize in Medicine. Banting shared the honours and award money with his colleague, Charles Best. That same year, the government of Canada granted Banting a lifetime annuity to continue his work. As to this day, Frederick Banting, who received the Nobel Prize at age 32, remains the youngest Nobel laureate for Physiology/Medicine. Early years Frederick Banting was born on November 14, 1891, in a farmhouse near Alliston, Ontario. The youngest of five children of William Thompson Banting and Margaret Grant, he attended public high school in Alliston. In 1910, he started at Victoria College, part of the University of Toronto, in the General Arts program. After failing his first year, he petitioned to join the m ...
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University College, University Of Toronto
University College, popularly referred to as UC, is a constituent college of the University of Toronto, created in 1853 specifically as an institution of higher learning free of religious affiliation. It was the founding member of the university's modern collegiate system, and its non-denominationalism contrasted with contemporary colleges at the time, such as Trinity College and St. Michael's College, both of which later became part of the University of Toronto. University College is one of two places in the University of Toronto that has been designated a National Historic Site of Canada, along with Annesley Hall of Victoria College. It is home to the oldest student government in Canada, the Literary and Athletic Society. History Shortly after taking power in the first responsible government of the Province of Canada, Reformist politicians led by Robert Baldwin wrested control of King's College from the Church of England in 1849 and renamed it the University of Toronto. B ...
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