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Chan Zuckerberg Biohub
Chan Zuckerberg Biohub (CZ Biohub), or simply Biohub, is a nonprofit research organization. In addition to supporting and conducting original research, CZ Biohub acts as a hub and fosters science collaboration between UC Berkeley, UC San Francisco (UCSF) and Stanford. The Biohub’s medical science research center is funded by a $600 million commitment from Facebook CEO and founder Mark Zuckerberg and his wife Priscilla Chan. It is currently co-led by Stephen Quake and Joseph DeRisi. Gajus Worthington was named as Biohub's Chief Operating Officer in 2017 and Sandra Schmid joined as Chief Scientific Officer in 2020. History The idea for CZ Biohub originated in 2015 when the current leaders, along with Mark Zuckerberg and Priscilla Chan, discussed the need for a collaborative effort by those three universities for fundamental medical research. The organization's aims are to cure, prevent, and manage disease by investigating diseases and developing diagnostics and therapies. It foc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph DeRisi
Joseph Lyman DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology. Life He received a B.S. in Biochemistry and Molecular Biology (1992) from the University of California, Santa Cruz, and a Ph.D. in biochemistry (1999) from Stanford University. Joseph DeRisi is a co-president of the Chan Zuckerberg Biohub, and Chair of the Department of Biochemistry and Biophysics at the University of California, San Francisco (UCSF) with a joint appointment at the California Institute for Quantitative Biosciences (QB3). He is a former Howard Hughes Medical Institute (HHMI) Investigator. DeRisi's best-known achievements are printing the first whole genome expression array, performing the first broad analysis of differential gene expression in cancer cells, profiling gene expression throughout the lifecycle of the malaria-causing protozoan '' Plasmodium falciparum'', his discovery of the SARS virus, and pioneering v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 ''Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in exp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California Botanical Garden
The University of California Botanical Garden is a 34-acre (13.7 ha) botanical garden located on the University of California, Berkeley campus, in Strawberry Canyon. The garden is in the Berkeley Hills, inside the city boundary of Oakland, California, Oakland, with views overlooking the San Francisco Bay. It is one of the most diverse plant collections in the United States, and famous for its large number of rare and endangered species. Description The garden was established in 1890 on the university's central campus. It was moved to its present location in the Berkeley Hills above the main campus under the directorship of Thomas Harper Goodspeed. The garden is about a mile from the Lawrence Hall of Science. The layout in Strawberry Canyon was designed by Goodspeed and fellow Berkeley professor and landscape architecture, landscape architect, John William Gregg. Collections The garden has more than 20,000 accessions, representing 324 plant families, 12,000 different species ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Francisco VA Medical Center
The San Francisco VA Medical Center, also called the San Francisco Veterans Affairs Medical Center or the SFVAMC, is a Veterans Affairs medical center, located in San Francisco. The main facility is on 42nd Avenue and Clement Street at the former Fort Miley Military Reservation in the Richmond District. Fort Miley is located south of the Golden Gate and west of the San Francisco Presidio, on Point Lobos (San Francisco) surrounded by the Golden Gate National Recreation Area. SFVAMC has the largest funded research program in the Veterans Health Administration with $90.2 million in research expenditures (2015).SFVAMC.gov: About the San Francisco VA Medical Center . accessed 12.1.2015. The current Medical Center Director is Bonnie S. Graham. It serves as a teaching hospital for the |
UCSF Medical Center
The University of California, San Francisco Medical Center is a research and teaching hospital in San Francisco, California and is the medical center of the University of California, San Francisco. It is affiliated with the UCSF School of Medicine. In 2022–23, it was ranked as the 12th-best overall hospital in the United States and one of the top three hospital in California by '' U.S. News & World Report''. It was founded in 1907 at the site of Parnassus Heights, on Mount Sutro, following the 1906 earthquake, and it was the first hospital in the University of California system. The university acquired Mount Zion Hospital in 1990, which became the second major clinical site and since 1999 has hosted the first comprehensive cancer center in Northern California. Beginning in 2001, the university expanded in the Mission Bay neighborhood and added a new medical center with three new hospitals. History The UCSF medical center opened as a hospital in 1907 with 75 beds, after t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinal Cord Injury Research
Spinal cord injury research seeks new ways to cure or treat spinal cord injury in order to lessen the debilitating effects of the injury in the short or long term. There is no cure for SCI, and current treatments are mostly focused on spinal cord injury rehabilitation and management of the secondary effects of the condition. Two major areas of research include neuroprotection, ways to prevent damage to cells caused by biological processes that take place in the body after the injury, and neuroregeneration, regrowing or replacing damaged neural circuits. Pathophysiology Primary and secondary injury, Secondary injury takes place minutes to weeks after the initial insult and includes a number of biochemical cascade, cascading processes that further harm tissues already damaged by the primary injury. It results in formation of a glial scar, which impedes axonal growth. Animal models Animals used as SCI model organisms in research include mice, rats, cats, dogs, pigs, and non-human p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
VA Palo Alto Health Care System
VA, Va and variants may refer to: Places * Vä, Sweden, a village * Vatican City (ISO 3166-1 country code VA) * Virginia, United States postal abbreviation Businesses and organizations Businesses * VA Software (also known as "VA Research" and "VA Linux Systems") a company that eventually became Geeknet * VA Tech Wabag, a company with headquarters in Austria and India * Virgin Atlantic, a worldwide airline owned by Richard Branson of the Virgin group * Virgin Australia (IATA code since 2011) * V Australia (IATA code 2009–2011) * Viasa (IATA code 1960–1997) Organizations * United States Department of Veterans Affairs, a department of the US government * VA (Public & Science), Swedish scientific organisation * Vermont Academy, boarding and day high school in Saxtons River, VT * VA, post nominal letters of the Royal Order of Victoria and Albert * VA, nickname for the French association football club Valenciennes FC * Virtual airline (hobby), flight simulation hobby organization ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BioRxiv
bioRxiv (pronounced "bio-archive") is an open access preprint repository for the biological sciences co-founded by John Inglis and Richard Sever in November 2013. It is hosted by the Cold Spring Harbor Laboratory (CSHL). As preprints, papers hosted on bioRxiv are not peer-reviewed, but undergo basic screening and checked against plagiarism. However, peer reviews from other sources may be posted alongside preprints. Moreover, readers may post comments. It has been measured that two thirds of the papers posted in bioRxiv are later published in peer-reviewed journals. A service called Rxivist parses the metadata of preprints from bioRxiv, and combines it with data from Twitter allowing to detect trending preprints. MedRxiv, and its sister site, bioRxiv, have been major sources for the dissemination of COVID-19 research. History BioRxiv was inspired by and intends to complement the arXiv repository, which mostly focuses on mathematics, physics and connected disciplines, launche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preprint
In academic publishing, a preprint is a version of a scholarly or scientific paper that precedes formal peer review and publication in a peer-reviewed scholarly or scientific journal. The preprint may be available, often as a non-typeset version available free, before or after a paper is published in a journal. History Since 1991, preprints have increasingly been distributed electronically on the Internet, rather than as paper copies. This has given rise to massive preprint databases such as arXiv and HAL (open archive) etc. to institutional repositories. The sharing of preprints goes back to at least the 1960s, when the National Institutes of Health circulated biological preprints. After six years the use of these Information Exchange Groups was stopped, partially because journals stopped accepting submissions shared via these channels. In 2017, the Medical Research Council started supporting citations of preprints in grant and fellowship applications, and Wellcome Trust star ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cas9
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense of certain bacteria against DNA viruses and plasmids, and is heavily utilized in genetic engineering applications. Its main function is to cut DNA and thereby alter a cell's genome. The CRISPR-Cas9 genome editing technique was a significant contributor to the Nobel Prize in Chemistry in 2020 being awarded to Emmanuelle Charpentier and Jennifer Doudna. More technically, Cas9 is a dual RNA-guided DNA endonuclease enzyme associated with the Clustered Regularly Interspaced Short Palindromic Repeats ( CRISPR) adaptive immune system in ''Streptococcus pyogenes''. ''S. pyogenes'' utilizes CRISPR to memorize and Cas9 to later interrogate and cleave foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking for sites complementary to the 20 nucleotide spacer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
