Cath Roberts
The CATH Protein Structure Classification database is a free, publicly available online resource that provides information on the evolutionary relationships of protein domains. It was created in the mid-1990s by Professor Christine Orengo and colleagues including Janet Thornton and David Tudor Jones, David Jones, and continues to be developed by the Orengo group at University College London. CATH shares many broad features with the Structural Classification of Proteins, SCOP resource, however there are also many areas in which the detailed classification differs greatly. Hierarchical organization Experimentally-determined protein three-dimensional structures are obtained from the Protein Data Bank and split into their consecutive polypeptide chains, where applicable. Protein domains are identified within these chains using a mixture of automatic methods and manual curation. The domains are then classified within the CATH structural hierarchy: at the Class (C) level, domains are as ...
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CATH - Protein Structure Classification Database
The CATH Protein Structure Classification database is a free, publicly available online resource that provides information on the evolutionary relationships of protein domains. It was created in the mid-1990s by Professor Christine Orengo and colleagues including Janet Thornton and David Tudor Jones, David Jones, and continues to be developed by the Orengo group at University College London. CATH shares many broad features with the Structural Classification of Proteins, SCOP resource, however there are also many areas in which the detailed classification differs greatly. Hierarchical organization Experimentally-determined protein three-dimensional structures are obtained from the Protein Data Bank and split into their consecutive polypeptide chains, where applicable. Protein domains are identified within these chains using a mixture of automatic methods and manual curation. The domains are then classified within the CATH structural hierarchy: at the Class (C) level, domains are as ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]