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Carlo M. Croce
Carlo Maria Croce (born December 17, 1944) is an Italian-American professor of medicine at Ohio State University, specializing in oncology and the molecular mechanisms underlying cancer. Croce and his research have attracted public attention because of multiple allegations of scientific misconduct. Education and career Croce graduated in 1969 ''summa cum laude'' in medicine from La Sapienza University of Rome. His research career in the United States began the following year at the Wistar Institute of Biology and Anatomy in Philadelphia. In 1980, Croce was named Wistar Professor of Genetics at the University of Pennsylvania and associate director of the Wistar Institute, and from 1988-1991 he was director of the Fels Institute for Cancer Research and Molecular Biology at Temple University School of Medicine. In 1991, Croce was named Director of the Kimmel Cancer Center at Jefferson Medical College at the Thomas Jefferson University in Philadelphia. In 1994, Croce joined the Counc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Milan, Italy
Milan ( , , Lombard language, Lombard: ; it, Milano ) is a city in northern Italy, capital of Lombardy, and the List of cities in Italy, second-most populous city proper in Italy after Rome. The city proper has a population of about 1.4 million, while its Metropolitan City of Milan, metropolitan city has 3.26 million inhabitants. Its continuously built-up List of urban areas in the European Union, urban area (whose outer suburbs extend well beyond the boundaries of the administrative Metropolitan cities of Italy, metropolitan city and even stretch into the nearby country of Switzerland) is the fourth largest in the EU with 5.27 million inhabitants. According to national sources, the population within the wider Milan metropolitan area (also known as Greater Milan), is estimated between 8.2 million and 12.5 million making it by far the List of metropolitan areas of Italy, largest metropolitan area in Italy and List of metropolitan areas in Europe, one of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FHIT
Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the ''FHIT'' gene. Function FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protectin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ching-Shih Chen
Ching-Shih Chen is the former Lucius A. Wing Chair of Cancer Research and professor of medicinal chemistry at Ohio State University (OSU). In 2018, Chen resigned his positions at OSU, and the university released a report on an investigation into Chen's scientific misconduct. As of 2020, Chen has had ten of his research publications retracted, two papers have received an expression of concern, and five others have been corrected. Chen was reported to university officials and the federal Office of Research Integrity after an anonymous email was sent to the university based on suspicion of falsifying data in six research projects. During the investigation, reports of falsification in additional projects arose. Chen initially blamed postdoctoral fellows and laboratory staff for the issues, but after a university investigation concluded that Chen "deviat dfrom the accepted practices of image handling and figure generation and intentionally falsif eddata" in 14 instances, including at lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Journal Of Biological Chemistry
The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. As of January 2021, the journal is fully open access. In press articles are available free on its website immediately after acceptance. Editors The following individuals have served as editors of the journal: * 1906–1909: John Jacob Abel and Christian Archibald Herter * 1909–1910: Christian Archibald Herter * 1910–1914: Alfred Newton Richards * 1914–1925: Donald D. Van Slyke * 1925–1936: Stanley R. Benedict. After Benedict died, John T. Edsall served as temporary editor until the next editor was appointed. * 1937–1958: Rudolph J. Anderson * 1958–1967: John T. Edsall * 1968–1971: William Howard Stein * 1971–2011: Herbert Tabor * 2011–2015: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Death And Differentiation
''Cell Death & Differentiation'' is a peer-reviewed academic journal An academic journal or scholarly journal is a periodical publication in which scholarship relating to a particular academic discipline is published. Academic journals serve as permanent and transparent forums for the presentation, scrutiny, and d ... published by Nature Research. Abstracted in References External links * Nature Research academic journals Molecular and cellular biology journals Academic journals established in 2002 {{Molec-cell-biology-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
WWOX
WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the ''WWOX'' gene. Function WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences Of The United States Of America
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are ava ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Cancer Research
''Clinical Cancer Research'' is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics. The applications of the disciplines of pharmacology, immunology, cell biology, and molecular genetics to intervention in human cancer are also included. One of the main interests of ''Clinical Cancer Research'' is on clinical trials that evaluate new treatments together with research on pharmacology and molecular alterations or biomarkers that predict response or resistance to treatment. Another priority for ''Clinical Cancer Research'' is laboratory and animal studies of new drugs as well as molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of the malignant phenotype, and metastatic disease. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clare Francis (science Critic)
Clare Francis is a pseudonym used since 2010 by the author (or authors) of hundreds of whistle-blowing emails sent to the editors of scientific journals that call attention to suspected cases of plagiarism and fabricated or duplicated figures.Ed Yong, Heidi Ledford & Richard Van NoordenResearch ethics: 3 ways to blow the whistle ''Nature'' (November 27, 2013). Described as a scientific gadfly, the pseudonymous Francis is "a source both legendary and loathed in biomedical circles" for their "uncanny knack for seeing improperly altered images, as well as smaller flaws that some editors are inclined to ignore."James Glanz & Agustin ArmendarizYears of Ethics Charges, but Star Cancer Researcher Gets a Pass ''New York Times'' (March 8, 2017). Francis refers to themself as an "attentive reader"; their "real identity, gender, and occupation remain secret."Kerry GrensWhat to do about "Clare Francis" '' The Scientist'' (September 14, 2013) Mixed response from editors Francis's complaints have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Office Of Research Integrity
The Office of Research Integrity (ORI) is a U.S. government agency that focuses on research integrity, especially in health. It was created when the Office of Scientific Integrity (OSI) in the National Institutes of Health (NIH) and the Office of Scientific Integrity Review (OSIR) in the Office of the Assistant Secretary for Health merged in May 1992. The Office of Research Integrity oversees and directs Public Health Service (PHS) research integrity activities on behalf of the Secretary of Health and Human Services, except for the regulatory research integrity activities of the Food and Drug Administration. Organizationally, ORI is located within the Office of the Assistant Secretary for Health (OASH) within the Office of the Secretary of Health and Human Services (OS), in the Department of Health and Human Services (HHS). Activities ORI carries out its responsibility by: * Developing policies, procedures and regulations related to the detection, investigation, and prevention of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. The majority of NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research instit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
