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Captopril Challenge Test
__NOTOC__ The captopril challenge test (CCT) is a non-invasive medical test that measures the change in renin Blood plasma, plasma-levels in response to administration of captopril, an angiotensin converting enzyme inhibitor. It is used to assist in the diagnosis of renal artery stenosis. It is not generally considered a useful test for children, and more suitable options are available for adult cases. Procedure Plasma concentration of renin is measured prior to and following the administration of captopril. The CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high. An abnormal captopril test is indicative of the presence of renovascular disease. In adults CCT in adults is known to have high sensitivity (tests), sensitivity, but a low Specificity (tests), specificity. Subtraction angiography is considered a more suitable test for renal artery stenosis in adults.Svetkey LP, Himmelstein SI, Dunnick NR, Wilkinson RH Jr, B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Captopril
Captopril, sold under the brand name Capoten among others, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inhibitor found for the treatment of hypertension. It does not cause fatigue as associated with beta-blockers. Due to the adverse drug event of causing hyperkalemia, as seen with most ACE Inhibitors, the medication is usually paired with a diuretic. Captopril was patented in 1976 and approved for medical use in 1980. Structure–activity relationship Captopril has an L-proline group which allows for it to be more bioavailable within oral formulations. The thiol moiety within the molecule has been associated with two significance adverse effects: the hapten or immune response. This immune response, also known as agranulocytosis, can explain the adverse drug events which may be seen in captopril with the allergic response, which would be: hives, severe s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
