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Candace Pert
Candace Beebe Pert (June 26, 1946 – September 12, 2013) was an American neuroscientist and pharmacologist who discovered the opiate receptor, the cellular binding site for endorphins in the brain. Early life and education She was born on June 26, 1946 in Manhattan, New York City. She completed her undergraduate studies in biology, ''cum laude'' in 1970 from Bryn Mawr College in Pennsylvania. Academic career In 1974, Candace Pert earned a Ph.D. in pharmacology from Johns Hopkins University School of Medicine, where she worked in the laboratory of Solomon Snyder and discovered the brain's opiate receptor. She also was the first person to isolate the T cell receptor. She tells the story of her discoveries in her book ''Molecules of Emotion. Pert conducted a National Institutes of Health Postdoctoral Fellowship with the Department of Pharmacology at the Johns Hopkins University School of Medicine from 1974 to 1975. She conducted research at the National Institute of Mental Health ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan, New York City
Manhattan (), known regionally as the City, is the most densely populated and geographically smallest of the five Boroughs of New York City, boroughs of New York City. The borough is also coextensive with New York County, one of the List of counties in New York, original counties of the U.S. state of New York (state), New York. Located near the southern tip of New York State, Manhattan is based in the Eastern Time Zone and constitutes both the geographical and demographic center of the Northeast megalopolis and the urban core of the New York metropolitan area, the largest metropolitan area in the world by urban area, urban landmass. Over 58 million people live within 250 miles of Manhattan, which serves as New York City’s economic and administrative center, cultural identifier, and the city’s historical birthplace. Manhattan has been described as the cultural, financial, Media in New York City, media, and show business, entertainment capital of the world, is considered a saf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Mental Health
The National Institute of Mental Health (NIMH) is one of 27 institutes and centers that make up the National Institutes of Health (NIH). The NIH, in turn, is an agency of the United States Department of Health and Human Services and is the primary agency of the United States government responsible for biomedical and health-related research. NIMH is the largest research organization in the world specializing in mental illness. Joshua A. Gordon is the current director of NIMH. The institute was first authorized by the U.S. government in 1946, when then President Harry Truman signed into law the National Mental Health Act, although the institute was not formally established until 1949. NIMH is a $1.5 billion enterprise, supporting research on mental health through grants to investigators at institutions and organizations throughout the United States and through its own internal (intramural) research effort. The mission of NIMH is "to transform the understanding and treatment of m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louise Hay
Louise Lynn Hay (October 8, 1926 – August 30, 2017) was an American motivational author and the founder of Hay House. She authored several New Thought self-help books, including the 1984 book '' You Can Heal Your Life''. Early life and career Born Helen Vera Lunney in Los Angeles to parents Henry John Lunney (1901–1998) and Veronica Chwala (1894–1985), Hay recounted her life story in an interview with Mark Oppenheimer of ''The New York Times'' in May 2008. In it, Hay stated that she was born in Los Angeles to a poor mother who remarried Louise's violent stepfather, Ernest Carl Wanzenreid (1903–1992), who physically abused her and her mother. When she was about 5, she was raped by a neighbor. At 15, she dropped out of University High School in Los Angeles without a diploma, became pregnant and, on her 16th birthday, gave up her newborn baby girl for adoption. She then moved to Chicago, where she worked in low-paying jobs. In 1950, she moved on again, to New York. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI) or psychoneuroendocrinoimmunology (PNEI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. It is a subfield of psychosomatic medicine. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology. The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dallas Buyers Club
''Dallas Buyers Club'' is a 2013 American biographical drama film written by Craig Borten and Melisa Wallack, and directed by Jean-Marc Vallée. The film tells the story of Ron Woodroof (Matthew McConaughey), an AIDS patient diagnosed in the mid-1980s when HIV/AIDS treatments were under-researched, while the disease was not understood and was highly stigmatized. As part of the experimental AIDS treatment movement, he smuggled unapproved pharmaceutical drugs into Texas for treating his symptoms, and distributed them to fellow people with AIDS by establishing the "Dallas Buyers Club" while facing opposition from the Food and Drug Administration (FDA). Two fictional supporting characters, Dr. Eve Saks (Jennifer Garner), and Rayon ( Jared Leto), were composite roles created from interviews with transgender AIDS patients, activists, and doctors. Presidential biographer and PEN-USA winner Bill Minutaglio wrote the first magazine profile of the Dallas Buyers Club in 1992. The article, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Washingtonian (magazine)
''Washingtonian'' is a monthly magazine distributed in the Washington, D.C. area. It was founded in 1965 by Laughlin Phillips and Robert J. Myers. The magazine describes itself as "The Magazine Washington Lives By". The magazine's core focuses are local feature journalism, guide book–style articles, real estate, and politics. Editorial content ''Washingtonian'' publishes information about local professionals, businesses, and notable places in Washington, D.C. Each issue includes information on popular local attractions, such as restaurants, neighborhoods, and entertainment, such as fine art and museum exhibits. There is a regular in-depth feature reporting on local institutions, politicians, businessmen, academics, and philanthropists.It also has information about essential services and real estate listings within Washington. Since 1971, the magazine has annually nominated up to 15 people as "Washingtonians of the Year"''.'' The magazine describes the award as honoring men a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HIV-associated Neurocognitive Disorder
HIV-associated neurocognitive disorders (HAND) are neurological disorders associated with HIV infection and AIDS. It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. HAND may include neurological disorders of various severity. HIV-associated neurocognitive disorders are associated with a metabolic encephalopathy induced by HIV infection and fueled by immune activation of macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of both host and viral origin. The essential features of HIV-associated dementia (HAD) are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterised by mental slowness, trouble with memory and poor concentration. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cognitive Effects Of HIV
HIV-associated neurocognitive disorders (HAND) are neurological disorders associated with HIV infection and AIDS. It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. HAND may include neurological disorders of various severity. HIV-associated neurocognitive disorders are associated with a metabolic encephalopathy induced by HIV infection and fueled by immune activation of macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of both host and viral origin. The essential features of HIV-associated dementia (HAD) are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterised by mental slowness, trouble with memory and poor concentration. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to child duri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptide T
Peptide T is an HIV entry inhibitor discovered in 1986 by Candace Pert and Michael Ruff, a US neuroscientist and immunologist. Peptide T, and its modified analog Dala1-peptide T-amide (DAPTA), a drug in clinical trials, is a short peptide derived from the HIV envelope protein gp120 which blocks binding and infection of viral strains which use the CCR5 receptor to infect cells. Peptide T has several positive effects related to HIV disease and Neuro-AIDS. A FDG-PET neuro-imaging study in an individual with AIDS dementia who completed a 12-wk treatment with intranasal DAPTA, showed remission in 34 out of 35 brain regions after treatment. A placebo-controlled, three site, 200+ patient NIH-funded clinical trial, which focused on neurocognitive improvements, was conducted between 1990 and 1995. The results showed that DAPTA was not significantly different from placebo on the study primary end points. However, 2 of 7 domains, abstract thinking and speed of information processing, did sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropeptide
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart. There are over 100 known neuropeptides, representing the largest and most diverse class of signaling molecules in the nervous system. Neuropeptides are synthesized from large precursor proteins which are cleaved and post-translationally processed then packaged into dense core vesicles. Neuropeptides are often co-released with other neuropeptides and neurotransmitters in a single neuron, yielding a multitude of effects. Once released, neuropeptides can diffuse widely to affect a broad range of targets. Synthesis Neuropeptides are synthesized from large, inactive precursor proteins called prepropeptides. Prepropeptides contain sequences for a family of distinct peptides and often contain repeated copies of the sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New York Times
''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid digital subscribers. It also is a producer of popular podcasts such as '' The Daily''. Founded in 1851 by Henry Jarvis Raymond and George Jones, it was initially published by Raymond, Jones & Company. The ''Times'' has won 132 Pulitzer Prizes, the most of any newspaper, and has long been regarded as a national " newspaper of record". For print it is ranked 18th in the world by circulation and 3rd in the U.S. The paper is owned by the New York Times Company, which is publicly traded. It has been governed by the Sulzberger family since 1896, through a dual-class share structure after its shares became publicly traded. A. G. Sulzberger, the paper's publisher and the company's chairman, is the fifth generation of the family to head the pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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