Can F 1

	Can F 1 Can f 1 or canis familiaris allergen 1 is a lipocalin allergen An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies. In technical terms ... produced by dogs in their tongue epithelial tissue. It is homologous with the human lipocalin LCN1. References Allergology Lipocalins Mammalian proteins {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Lipocalin The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids and most lipocalins are also able to bind to complexed iron (via siderophores or flavonoids) as well as heme. They share limited regions of sequence homology and a common tertiary structure architecture. This is an eight stranded antiparallel beta barrel with a repeated + 1 topology enclosing an internal ligand binding site. These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. Lipocalins have been associated with many biological processes, among them immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. Function Immune response Lipocalin proteins are important key players of nutritional immunity by withholding and sequestering micronutrients. They are thereby able to regulate inflammatory and detoxification processe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Allergen An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body. Such reactions are called allergies. In technical terms, an allergen is an antigen that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals through immunoglobulin E (IgE) responses. Most humans mount significant Immunoglobulin E responses only as a defense against parasitic infections. However, some individuals may respond to many common environmental antigens. This hereditary predisposition is called atopy. In atopic individuals, non-parasitic antigens stimulate inappropriate IgE production, leading to type I hypersensitivity. Sensitivities vary widely from one person (or from one animal) to another. A very broad range of substances can be allergens to sensitive individuals. Types of allergens Allergens can be found in a variety of sources, such as dust mite e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	LCN1 Lipocalin-1 is a protein that in humans is encoded by the ''LCN1'' gene. The protein encoded by this gene belongs to the lipocalin family. Lipocalins are a group of extracellular proteins that are able to bind lipophiles by enclosure within their structures to minimize solvent contact. This protein may bind hydrophobic ligands and inhibit cysteine proteinases. It may also play a role in taste reception. Structure Proteins are classified into the lipocalin family by their 8 antiparallel beta-sheets that form a barrel structure which acts as the binding site for ligands. Function Lipocalin-1 (LCN1) is capable of binding a wide variety of lipophilic molecules along with zinc and chloride ions. Because of this feature, LCN1’s main function is thought to be the removal of potentially harmful lipids and lipophilic molecules from the body by binding them. The LCN1-Ligand complex is then imported via Lipocalin-1-Interacting Membrane Receptor (LIMR) so the bound molecule can be brok ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Allergology Allergies, also known as allergic diseases, refer a number of conditions caused by the hypersensitivity of the immune system to typically harmless substances in the environment. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Note: food intolerances and food poisoning are separate conditions. Common allergens include pollen and certain foods. Metals and other substances may also cause such problems. Food, insect stings, and medications are common causes of severe reactions. Their development is due to both genetic and environmental factors. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine. Diagnosis is t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]