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Camptotheca
''Camptotheca'' (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to tall, native to southern China and Tibet. The genus is usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. The name "happy tree" is a direct translation of the Chinese name xǐ shù (Simplified Chinese:喜树). There are two species: *''Camptotheca acuminata'' Decne. *''Camptotheca lowreyana'' S.Y.Li The bark and stems of ''C. acuminata'' contain the alkaloid camptothecin. Several chemical derivatives of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. ''C. acuminata'' also contains the chemical compounds trifolin and hyperoside Hyperoside is a chemical compound. It is the 3-''O''-galactoside of quercetin. Natural occurrences Hyperoside has been isolated from ''Drosera rotundifolia'', from the Lamiaceae ''Stachys sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptotheca Acuminata
''Camptotheca'' (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to tall, native to southern China and Tibet. The genus is usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. The name "happy tree" is a direct translation of the Chinese name xǐ shù (Simplified Chinese:喜树). There are two species: *''Camptotheca acuminata'' Decne. *''Camptotheca lowreyana'' S.Y.Li The bark and stems of ''C. acuminata'' contain the alkaloid camptothecin. Several chemical derivatives of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. ''C. acuminata'' also contains the chemical compounds trifolin and hyperoside Hyperoside is a chemical compound. It is the 3-''O''-galactoside of quercetin. Natural occurrences Hyperoside has been isolated from ''Drosera rotundifolia'', from the Lamiaceae ''Stachys sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptotheca Lowreyana
''Camptotheca'' (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to tall, native to southern China and Tibet. The genus is usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae. The name "happy tree" is a direct translation of the Chinese name xǐ shù (Simplified Chinese:喜树). There are two species: *''Camptotheca acuminata'' Decne. *''Camptotheca lowreyana'' S.Y.Li The bark and stems of ''C. acuminata'' contain the alkaloid camptothecin. Several chemical derivatives of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. ''C. acuminata'' also contains the chemical compounds trifolin and hyperoside Hyperoside is a chemical compound. It is the 3-''O''-galactoside of quercetin. Natural occurrences Hyperoside has been isolated from ''Drosera rotundifolia'', from the Lamiaceae ''Stachys sp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of ''Camptotheca acuminata'' (Camptotheca, Happy tree), a tree native to China used in traditional Chinese medicine. It has been used clinically more recently in China for the treatment of gastrointestinal tumors. CPT showed anticancer activity in preliminary clinical trials, especially against breast, ovarian, colon, lung, and stomach cancers. However, it has low solubility and adverse effects have been reported when used therapeutically, so synthetic and medicinal chemists have developed numerous syntheses of camptothecin and various derivatives to increase the benefits of the chemical, with good results. Four CPT analogues have been approved and are used in cancer chemotherapy today, topotecan, irinotecan, belotecan, and trastuzumab deruxtecan. Camptothecin has also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyperoside
Hyperoside is a chemical compound. It is the 3-''O''-galactoside of quercetin. Natural occurrences Hyperoside has been isolated from ''Drosera rotundifolia'', from the Lamiaceae ''Stachys sp.'' and ''Prunella vulgaris'', from ''Rumex acetosella'', ''Cuscuta chinensis'' seeds, from St John's wort and from ''Camptotheca acuminata''. It is one of the phenolic compounds in the invasive plant ''Carpobrotus edulis'' and contributes to the antibacterial properties of the plant. In ''Rheum nobile'' and '' R. rhaponticum'', it serves as a UV blocker found in the bracts. It is also found in ''Geranium niveum'' and ''Taxillus kaempferi ''Taxillus kaempferi'' () is a parasitic plant A parasitic plant is a plant that derives some or all of its nutritional requirements from another living plant. They make up about 1% of angiosperms and are found in almost every biome. All para ...''.The constituents of Taxillus kaempferi and the host, Pinus thunbergii. I. Catechins and flavones of Tax ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trifolin
Trifolin is a chemical compound. It is the kaempferol 3-galactoside. It can be found in ''Camptotheca acuminata'', in '' Euphorbia condylocarpa'' or in '' Consolida oliveriana''. Kaempferol 3-O-galactosyltransferase is an enzyme that catalyzes the chemical reaction: UDP-galactose + kaempferol → UDP + kaempferol 3-O-beta-D-galactoside (trifolin). It can also be found in seedlings of ''Vigna mungo ''Vigna mungo'', also known as black gram, urad bean, urid bean, mash kalai, uzhunnu parippu, ulundu paruppu, minapa pappu, uddu, or black matpe, is a bean grown in South Asia. Like its relative, the mung bean, it has been reclassified from th ...''. References Kaempferol glycosides Flavonoid galactosides {{Aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topotecan
Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. It is a synthetic, water-soluble analog of the natural chemical compound camptothecin. It is used in the form of its hydrochloride salt to treat ovarian cancer, lung cancer and other cancer types. After GlaxoSmithKline received final FDA approval for topotecan on October 15, 2007, it became the first topoisomerase I inhibitor for oral use. Uses * Ovarian cancer (FDA May 1996). * Cervical cancer (FDA June 2006). * Small cell lung carcinoma (SCLC) (FDA Oct 2007). Experimental uses As of 2016, experiments were under way for Neuroblastoma, Brainstem glioma, Ewing's sarcoma and Angelman's syndrome. In addition, topotecan is experimentally treating Non-small cell lung cancer, Colorectal Cancer, Breast cancer, Non-Hodgkin Lymphoma, Endometrial cancer, and Oligodendroglioma. Angelman's syndrome Angelman's syndrome is a neuro-genetic disorder cha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trees Of China
In botany, a tree is a perennial plant with an elongated stem, or trunk, usually supporting branches and leaves. In some usages, the definition of a tree may be narrower, including only woody plants with secondary growth, plants that are usable as lumber or plants above a specified height. In wider definitions, the taller palms, tree ferns, bananas, and bamboos are also trees. Trees are not a taxonomic group but include a variety of plant species that have independently evolved a trunk and branches as a way to tower above other plants to compete for sunlight. The majority of tree species are angiosperms or hardwoods; of the rest, many are gymnosperms or softwoods. Trees tend to be long-lived, some reaching several thousand years old. Trees have been in existence for 370 million years. It is estimated that there are some three trillion mature trees in the world. A tree typically has many secondary branches supported clear of the ground by the trunk. This trunk typically c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nyssaceae
Nyssaceae is a family of flowering trees sometimes included in the dogwood family (Cornaceae). Nyssaceae is composed of 37 known species in the following five genera:Averyanov, L. V. & Hiep, N. T. (2002). ''Diplopanax vietnamensis'', a New Species of Nyssaceae from Vietnam – One More Living Representative of the Tertiary Flora of Eurasia. ''Novon'' 12: 433–436. Availablonline (pdf)/ref> *''Camptotheca'', the happy trees: two species in China *'' Davidia'', the dove tree, handkerchief tree, or ghost tree: one species in central China *''Diplopanax'': two species in southern China and Vietnam *''Mastixia'': about nineteen species in Southeast Asia *'' Nyssa'', the tupelos: about 7–10 species in eastern North America and East to Southeast Asia Among the extinct genera of the family are '' Mastixicarpum'', very similar to ''Diplopanax'', and '' Tsukada'', an extinct relative of ''Davidia''. In some treatments, ''Davidia'' is split off into its own family, the Davidiaceae. ''Dip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irinotecan
Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is used with cisplatin. It is given intravenously. Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, shortness of breath, and fever. Other severe side effects include blood clots, colon inflammation, and allergic reactions. Those with two copies of the UGT1A1*28 gene variant are at higher risk for side effects. Use during pregnancy can result in harm to the baby. Irinotecan is a topoisomerase inhibitor—it blocks the topoisomerase I enzyme, resulting in DNA damage and cell death. Irinotecan was approved for medical use in the United States in 1996. It is on the World Health Organization's List of Essential Medicines. It is made from the natural compound camptothecin which is found in the Chinese ornamental tree ''Campt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Decaisne
Joseph Decaisne (7 March 1807 – 8 January 1882) was a French botanist and agronomist. He became an ''aide-naturaliste'' to Adrien-Henri de Jussieu (1797-1853), who served as the chair of rural botany. It was during this time that he began to study plants brought back by various travelers like those of Victor Jacquemont (1801-1832) from Asia. Decaisne used applied research, most notably on the agronomy of the Rubia tinctorum, madder, the Yam (vegetable), yam and the ramie. He was also interested in algae. Biography Although born in Brussels, Belgium, he exercised his activity exclusively in Paris. He entered in 1824 as a gardener at the ''Muséum national d'histoire naturelle'' (French museum of natural history) and became, in 1832, head of the ''carré des semis'' section. He also worked at the ''Jardin des Plantes'' and collaborated with Asa Gray. In 1847 he chaired Statistical Agriculture department in the College de France. In 1850, Decaisne followed Charles-François Brisse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tree
In botany, a tree is a perennial plant with an elongated stem, or trunk, usually supporting branches and leaves. In some usages, the definition of a tree may be narrower, including only woody plants with secondary growth, plants that are usable as lumber or plants above a specified height. In wider definitions, the taller palms, tree ferns, bananas, and bamboos are also trees. Trees are not a taxonomic group but include a variety of plant species that have independently evolved a trunk and branches as a way to tower above other plants to compete for sunlight. The majority of tree species are angiosperms or hardwoods; of the rest, many are gymnosperms or softwoods. Trees tend to be long-lived, some reaching several thousand years old. Trees have been in existence for 370 million years. It is estimated that there are some three trillion mature trees in the world. A tree typically has many secondary branches supported clear of the ground by the trunk. This trunk typically ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deciduous
In the fields of horticulture and Botany, the term ''deciduous'' () means "falling off at maturity" and "tending to fall off", in reference to trees and shrubs that seasonally shed leaves, usually in the autumn; to the shedding of petals, after flowering; and to the shedding of ripe fruit. The antonym of ''deciduous'' in the botanical sense is evergreen. Generally, the term "deciduous" means "the dropping of a part that is no longer needed or useful" and the "falling away after its purpose is finished". In plants, it is the result of natural processes. "Deciduous" has a similar meaning when referring to animal parts, such as deciduous antlers in deer, deciduous teeth (baby teeth) in some mammals (including humans); or decidua, the uterine lining that sheds off after birth. Botany In botany and horticulture, deciduous plants, including trees, shrubs and herbaceous perennials, are those that lose all of their leaves for part of the year. This process is called abscissio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
