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Caliper Life Sciences
Caliper, A PerkinElmer Company produces products and services for life sciences research. The firm, founded in 1995, is based in Hopkinton, Massachusetts with direct sales, service and application-support operations in countries around the globe. The firm's products include instruments, software and reagents, laboratory automation tools microfluidics, lab automation & liquid handling, optical imaging technologies, and services for drug discovery & drug development. Products Microfluidic platform Caliper is a pioneer in microfluidic lab-on-a-chip technology. Its microfluidic lab-on-a-chip products, including a proprietary microfluidic sipper chip, are a high-throughput complement to the firm's planar chips. The microfluidic technology forms the basis of the firm's reader systems used for drug screening and profiling and for molecular biology DNA, RNA and protein analysis. Optical imaging Through its acquisition of Xenogen Corporation in 2006, the firm is now ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caliper Logo
A caliper (British spelling also calliper, or in plurale tantum sense a pair of calipers) is a device used to measure the dimensions of an object. Many types of calipers permit reading out a measurement on a ruled scale, a dial, or a digital display. Some calipers can be as simple as a compass with inward or outward-facing points, but no scale. The tips of the caliper are adjusted to fit across the points to be measured and the dimension read by measuring between the tips with another measuring tool, such as a ruler. It is used in many fields such as mechanical engineering, metalworking, forestry, woodworking, science and medicine. Plural vs. singular A single tool might be referred to as a "caliper" or as "calipers", like a pair of scissors or glasses (a "plural only" or ''plurale tantum'' form). In colloquial usage, the phrase "pair of verniers" or just " vernier" might refer to a vernier caliper. Colloquially these phrases can also refer to dial calipers, although they i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vivo
Studies that are ''in vivo'' (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism. This is not to be confused with experiments done ''in vitro'' ("within the glass"), i.e., in a laboratory environment using test tubes, Petri dishes, etc. Examples of investigations ''in vivo'' include: the pathogenesis of disease by comparing the effects of bacterial infection with the effects of purified bacterial toxins; the development of non-antibiotics, antiviral drugs, and new drugs generally; and new surgical procedures. Consequently, animal testing and clinical trials are major elements of ''in vivo'' research. ''In vivo'' testing is often employed over ''in vitro'' because it is better suited for observing the overall effects of an experiment on a living subject. In dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Sciences Industry
Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energy transformation, and reproduction. Various forms of life exist, such as plants, animals, fungi, protists, archaea, and bacteria. Biology is the science that studies life. The gene is the unit of heredity, whereas the cell is the structural and functional unit of life. There are two kinds of cells, prokaryotic and eukaryotic, both of which consist of cytoplasm enclosed within a membrane and contain many biomolecules such as proteins and nucleic acids. Cells reproduce through a process of cell division, in which the parent cell divides into two or more daughter cells and passes its genes onto a new generation, sometimes producing genetic variation. Organisms, or the individual entities of life, are generally thought to be open systems that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology Companies Of The United States
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taconic Biosciences
Taconic Biosciences is a private biotechnology company specializing in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services. The company was founded in 1952 as Taconic Farms. The company has three service laboratories and six breeding facilities in the U.S. and Europe, and is headquartered in Rensselaer, New York. Company overview Taconic Biosciences is a breeder and supplier of laboratory animals operating in over 50 countries. The current CEO is Nancy J. Sandy. As of 2016, the company has over 800 employees and 1300 customers. They produce selectively bred and genetically engineered mice and rats for research use. History * 1949 – Robert Phelan began shipping mice from his garage in Canajoharie, NY. * 1952 – Taconic Farms is officially founded in Germantown, NY. * 1955 – Robert dies, leaving the company to his wife, Sally, and sons, Joseph, Richard, and Samuel. * 1963 – Contracted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dionex
Dionex Corporation is an American company based in Sunnyvale, California. It develops, manufactures, sells, and services analytical chromatography systems for separating, isolating, and identifying the components of chemical mixtures. Such equipment is used in pharmaceutical manufacturing, medical research, environmental monitoring, and food testing. In December 2010 Thermo Fisher Scientific announced its acquisition of Dionex for $2.1 billion. Products Software Dionex developed the ''Chromeleon'' brand of chromatography software. The primary function of Chromeleon is to control and obtain data from analytical instruments, such as Gas chromatography, GC, Liquid chromatography, LC, Ion Exchange Chromatography, IEX and Mass spectrometry, MS. Chromeleon is fully Title 21 CFR Part 11 compliant. Chromeleon 7.3 is the latest edition of the software. Hardware The technology made by Dionex includes the Rapid Separation LC (RSLC) and polymeric HPLC columns, a type of monolithic HPLC column ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Larry Bock
Lawrence A. Bock (September 21, 1959July 6, 2016) was an American entrepreneur who has aided in starting or financing 50 early-stage growth companies, with a combined market value of more than $70 billion. Personal life Bock was born in Brooklyn, New York, and raised in Chappaqua to parents Ulrike Proctor and Richard Bock. Larry had one older sibling Steven who was deaf. He received a degree in biochemistry from Bowdoin College and an MBA from UCLA. After school, he worked for Genentech. Bock was a donor, co-founder, and the executive director of USA Science and Engineering Festival. Bock was married to Diane Birnie Bock for thirty years and had two daughters, Quincy Bock Stokes and Tasha Bock (Scruggs). Blindness Bock suffered from Stargardt disease, an inherited form of macular degeneration that causes progressive loss of vision. He was legally blind by the age of 29. Career Bock was highlighted as a "keystone species" in the ecosystem of Silicon Valley in the book ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Repositioning
Drug repositioning (also called drug repurposing) involves the investigation of existing drugs for new therapeutic purposes. Repurposing achievements A number of successes have been achieved, the foremost including sildenafil (Viagra) for erectile dysfunction and pulmonary hypertension and thalidomide for leprosy and multiple myeloma. Clinical trials have been performed on posaconazole and ravuconazole for Chagas disease. Other antifungal agents clotrimazole and ketoconazole have been investigated for anti- trypanosome therapy. Successful repositioning of antimicrobials has led to the discovery of broad-spectrum therapeutics, which are effective against multiple infection types. In psychiatry, repurposed drugs are emerging as feasible options to treat severe mental disorders. Strategy Drug repositioning is a "universal strategy" for neglected diseases due to 1) reduced number of required clinical trial steps could reduce the time and costs for the medicine to reach mar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Assays
An assay is an investigative (analytic) procedure in laboratory medicine, mining, pharmacology, environmental biology and molecular biology for qualitatively assessing or quantitatively measuring the presence, amount, or functional activity of a target entity. The measured entity is often called the analyte, the measurand, or the target of the assay. The analyte can be a drug, biochemical substance, chemical element or compound, or cell in an organism or organic sample. An assay usually aims to measure an analyte's intensive property and express it in the relevant measurement unit (e.g. molarity, density, functional activity in enzyme international units, degree of effect in comparison to a standard, etc.). If the assay involves exogenous reactants (the reagents), then their quantities are kept fixed (or in excess) so that the quantity and quality of the target are the only limiting factors. The difference in the assay outcome is used to deduce the unknown quality or quantity of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Solid Phase Extraction
Solid-phase extraction (SPE) is an extractive technique by which compounds that are dissolved or suspended in a liquid mixture are separated from other compounds in the mixture according to their physical and chemical properties. Analytical laboratories use solid phase extraction to concentrate and purify samples for analysis. Solid phase extraction can be used to isolate analytes of interest from a wide variety of matrices, including urine, blood, water, beverages, soil, and animal tissue. SPE uses the affinity of solutes dissolved or suspended in a liquid (known as the mobile phase) for a solid through which the sample is passed (known as the stationary phase) to separate a mixture into desired and undesired components. The result is that either the desired analytes of interest or undesired impurities in the sample are retained on the stationary phase. The portion that passes through the stationary phase is collected or discarded, depending on whether it contains the desired ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robotic
Robotics is an interdisciplinarity, interdisciplinary branch of computer science and engineering. Robotics involves design, construction, operation, and use of robots. The goal of robotics is to design machines that can help and assist humans. Robotics integrates fields of mechanical engineering, electrical engineering, Information engineering (field), information engineering, mechatronics, electronics, bioengineering, computer engineering, control engineering, software engineering, mathematics, etc. Robotics develops machines that can substitute for humans and replicate human actions. Robots can be used in many situations for many purposes, but today many are used in dangerous environments (including inspection of radioactive materials, bomb detection and bomb disposal, deactivation), manufacturing processes, or where humans cannot survive (e.g. in space, underwater, in high heat, and clean up and containment of hazardous materials and radiation). Robots can take any form, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
