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COX8A
Cytochrome ''c'' oxidase subunit 8A (COX8A) is a protein that in humans is encoded by the ''COX8A'' gene. Cytochrome ''c'' oxidase 8A is a subunit of the cytochrome c oxidase complex, also known as Complex IV. Mutations in the ''COX8A'' gene have been associated with complex IV deficiency with Leigh syndrome and epilepsy. Structure COX8A is a 7.6 kDa protein composed of 69 amino acids. This gene encodes the nuclear-encoded subunit 8A of the human mitochondrion, mitochondrial Electron transport chain, respiratory chain enzyme complex Cytochrome c oxidase, cytochrome ''c'' oxidase. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. Function Cytochrome c oxidase, Cytochrome ''c'' oxidase (COX) is the terminal enzyme of the mitochondrion, mitochondrial Electron transport chain, respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from Cytochrome c oxidase, cytochrome ''c'' to molecular oxygen and contributes to a pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complex IV
The enzyme cytochrome c oxidase or Complex IV, (was , now reclassified as a translocasEC 7.1.1.9 is a large transmembrane protein complex found in bacteria, archaea, and mitochondria of eukaryotes. It is the last enzyme in the respiratory electron transport chain of cells located in the membrane. It receives an electron from each of four cytochrome c molecules and transfers them to one oxygen molecule and four protons, producing two molecules of water. In addition to binding the four protons from the inner aqueous phase, it transports another four protons across the membrane, increasing the transmembrane difference of proton electrochemical potential, which the ATP synthase then uses to synthesize ATP. Structure The complex The complex is a large integral membrane protein composed of several metal prosthetic sites and 14 protein subunits in mammals. In mammals, eleven subunits are nuclear in origin, and three are synthesized in the mitochondria. The complex contains two ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
