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COUP-TF
The chicken ovalbumin upstream promoter transcription factor (COUP-TFs) proteins are members of the nuclear receptor family of intracellular transcription factors. There are two variants of the COUP-TFs, labeled as COUP-TFI and COUP-TFII COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the ''NR2F2'' gene. The COUP acronym stands for chicken ovalbumin upstream promoter. Functio ... encoded by the and genes respectively. COUP-TFs play critical roles in the development of organisms. References External links * * * Intracellular receptors Transcription factors {{gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COUP-TFII
COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the ''NR2F2'' gene. The COUP acronym stands for chicken ovalbumin upstream promoter. Function COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs. The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity. COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation. Structure and ligands The structure of COUP-TF2 LBD is known. Retinoic acid, although not at physiological concentrations, activate this receptor. Interactions COUP-TFII has been shown to interact with: * HDAC1 * Lck * V-erbA-related gene. * Nucleolin Nucleolin is a protein that in humans is encoded by the ''NCL'' gene. Gene The human NCL gene is located on chromosome 2 and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COUP-TFI
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the ''NR2F1'' gene. This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Function Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein ( S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Interactions COUP-TFI has been shown to interact with: * BCL11A, * BCL11B, * COPS2, and * ESR1. Clinical Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome Bosch-Boonstra-Schaaf optic atrophy syndrome is a rare autosomally inherited condition characterised by developmental delay, intellectual disability and decreased visual acuity.Bosch DGM, Boonstra FN, Gonzaga-Jauregui C, Xu, M, de Ligt J, Jhan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Receptor
In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand—a molecule that affects the receptor's behavior. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up- or down-regulation of gene expression. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Nuclear receptors play key roles in both embryonic development a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intracellular
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms. It is intended as introductory material for novices; for more specific and technical definitions from sub-disciplines and related fields, see Glossary of genetics, Glossary of evolutionary biology, Glossary of ecology, and Glossary of scientific naming, or any of the organism-specific glossaries in :Glossaries of biology. A B C D E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intracellular Receptors
Intracellular receptors are Globular protein receptors located inside the cell rather than on its cell membrane. The word ''intracellular'' means "within or inside a cell". Molecules that cross a cell membrane to bind with a receptor are generally nonpolar and may be relatively small. These molecules are also known as ligands. Hormones that use intracellular receptors include thyroid, aldosterone, and steroid hormones. Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors. Examples * transcription factors ** nuclear receptors * other ** Sigma1 (neurosteroids) ** IP3 receptor (inositol triphosphate, IP3) See also * Receptor * Steroid hormone A ster ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
