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COBL (gene)
Protein cordon-bleu is a protein that in humans is encoded by the COBL gene. The Cordon-bleu protein was first described in 2007. Cobl was demonstrated to be a brain-enriched, Wiskott-Aldrich Homology 2 WH2 domain-based actin nucleator playing a pivotal role in morphogenetic processes in the vertebrate central nervous system (CNS) that give rise to the complex dendritic arbor of neuronal cells. The Cobl gene was originally identified in lacZ-gene-trap experiments in mice. Cobl mRNA was detected as early as at day 7.5 post-coitum (E7.5) in the gastrula organizer and extended towards the axial midline at E8. The organizer is a small group of embryonal cells that organizes the entire body plan because it gives rise to the axial midline – an important source of patterning and morphogenesis cues. The human ''COBL'' gene encodes a 1261-amino acid protein with a mass of about 136 kDa. The mouse protein is 1337 amino acids long. The cobl gene in mice and human gives rise to a varie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spire (protein)
A spire is a tall, slender, pointed structure on top of a roof of a building or tower, especially at the summit of church steeples. A spire may have a square, circular, or polygonal plan, with a roughly conical or pyramidal shape. Spires are typically made of stonework or brickwork, or else of timber structures with Cladding (construction), metal cladding, ceramic tile, ceramic tiling, roof shingles, or Slate roof, slates on the exterior. Since towers supporting spires are usually square, square-plan spires emerge directly from the tower's walls, but octagonal spires are either built for a pyramidal transition section called a ''Broach spire, broach'' at the spire's base, or else freed spaces around the tower's summit for decorative elements like pinnacles. The former solution is known as a ''broach spire''. Small or short spires are known as ''spikes'', ''spirelets'', or ''flèche (architecture), flèches''. Etymology This sense of the word spire is attested in English since ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ex Vivo
''Ex vivo'' (Latin: "out of the living") literally means that which takes place outside an organism. In science, ''ex vivo'' refers to experimentation or measurements done in or on tissue from an organism in an external environment with minimal alteration of natural conditions. Testing the effect of compounds on skin biopsies is an example of ''ex vivo'' research, while isolating the primary cells from that biopsy and creating a 3D cell culture model is an example of ''in vitro'' research. Both use human tissues, but the former is a more complex and translational environment for drug testing. A primary advantage of using ''ex vivo'' tissues is the ability to perform tests or measurements that would otherwise not be possible or ethical in living subjects. Tissues may be experimented on in many ways, including in part (e.g. cardiac contractility models using atrial pectinate muscles) or as whole organs (e.g. isolated perfused heart model). Examples of ''ex vivo'' models include: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Working Model Of Cobl-induced Actin Nucleation
Working may refer to: * Work (human activity), intentional activity people perform to support themselves, others, or the community Arts and media * ''Working'' (musical), a 1978 musical * ''Working'' (TV series), an American sitcom * ''Working'' (Caro book), a 2019 book by Robert Caro * ''Working'' (Terkel book), a 1974 book by Studs Terkel * '' Working!!'', a manga by Karino Takatsu * "Working" (song), by Tate McRae and Khalid, 2021 Engineering and technology * Cold working or cold forming, the shaping of metal below its recrystallization temperature * Hot working, the shaping of metal above its recrystallization temperature * Multiple working, having more than one locomotive under the control of one driver * Live-line working, the maintenance of electrical equipment while it is energised * Single-line working, using one train track out of two Other uses * Holbrook Working (1895–1985), statistician and economist * Working the system, exploiting rules and procedur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microfilament
Microfilaments, also called actin filaments, are protein filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton. They are primarily composed of polymers of actin, but are modified by and interact with numerous other proteins in the cell. Microfilaments are usually about 7 nm in diameter and made up of two strands of actin. Microfilament functions include cytokinesis, amoeboid movement, cell motility, changes in cell shape, endocytosis and exocytosis, cell contractility, and mechanical stability. Microfilaments are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton tensile forces. In inducing cell motility, one end of the actin filament elongates while the other end contracts, presumably by myosin II molecular motors. Additionally, they function as part of actomyosin-driven contractile molecular motors, wherein the thin filaments serve as tensile platforms for myosin's ATP-de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Splicing
RNA splicing is a process in molecular biology where a newly-made precursor messenger RNA (pre-mRNA) transcript is transformed into a mature messenger RNA (mRNA). It works by removing all the introns (non-coding regions of RNA) and ''splicing'' back together exons (coding regions). For nuclear-encoded genes, splicing occurs in the nucleus either during or immediately after transcription. For those eukaryotic genes that contain introns, splicing is usually needed to create an mRNA molecule that can be translated into protein. For many eukaryotic introns, splicing occurs in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs). There exist self-splicing introns, that is, ribozymes that can catalyze their own excision from their parent RNA molecule. The process of transcription, splicing and translation is called gene expression, the central dogma of molecular biology. Splicing pathways Several methods of RNA splici ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structure Cobl
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as biological organisms, minerals and chemicals. Abstract structures include data structures in computer science and musical form. Types of structure include a hierarchy (a cascade of one-to-many relationships), a network featuring many-to-many links, or a lattice featuring connections between components that are neighbors in space. Load-bearing Buildings, aircraft, skeletons, anthills, beaver dams, bridges and salt domes are all examples of load-bearing structures. The results of construction are divided into buildings and non-building structures, and make up the infrastructure of a human society. Built structures are broadly divided by their varying design approaches and standards, into categories including building st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
