Spinareovirinae
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Spinareovirinae
''Spinareovirinae'' is a subfamily of double-stranded RNA viruses in the family ''Reoviridae''. Viruses in this group are distinguished by the presence of a turreted protein on the inner capsid. (''Spina'' = spiny or thorny in Latin.) Taxonomy The subfamily has nine genera: *'' Aquareovirus'' *''Coltivirus'' *''Cypovirus'' *'' Dinovernavirus'' *'' Fijivirus'' *'' Idnoreovirus'' *'' Mycoreovirus'' *''Orthoreovirus ''Orthoreovirus'' is a genus of viruses, in the family ''Reoviridae'', in the subfamily '' Spinareovirinae''. Vertebrates serve as natural hosts. There are ten species in this genus. Diseases associated with this genus include mild upper respirat ...'' *'' Oryzavirus'' References Reoviruses Virus subfamilies {{virus-stub ...
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Spinareovirinae
''Spinareovirinae'' is a subfamily of double-stranded RNA viruses in the family ''Reoviridae''. Viruses in this group are distinguished by the presence of a turreted protein on the inner capsid. (''Spina'' = spiny or thorny in Latin.) Taxonomy The subfamily has nine genera: *'' Aquareovirus'' *''Coltivirus'' *''Cypovirus'' *'' Dinovernavirus'' *'' Fijivirus'' *'' Idnoreovirus'' *'' Mycoreovirus'' *''Orthoreovirus ''Orthoreovirus'' is a genus of viruses, in the family ''Reoviridae'', in the subfamily '' Spinareovirinae''. Vertebrates serve as natural hosts. There are ten species in this genus. Diseases associated with this genus include mild upper respirat ...'' *'' Oryzavirus'' References Reoviruses Virus subfamilies {{virus-stub ...
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Reoviridae
''Reoviridae'' is a family of double-stranded RNA viruses. Member viruses have a wide host range, including vertebrates, invertebrates, plants, protists and fungi. They lack lipid envelopes and package their segmented genome within multi-layered capsids. Lack of a lipid envelope has allowed three-dimensional structures of these large complex viruses (diameter ∼60–100 nm) to be obtained, revealing a structural and likely evolutionary relationship to the cystovirus family of bacteriophage. There are currently 97 species in this family, divided among 15 genera in two subfamilies. Reoviruses can affect the gastrointestinal system (such as rotaviruses) and respiratory tract. The name "reo-" is an acronym for "''r''espiratory ''e''nteric ''o''rphan" viruses''.'' The term "orphan virus" refers to the fact that some of these viruses have been observed not associated with any known disease. Even though viruses in the family ''Reoviridae'' have more recently been identified with vario ...
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Reoviruses
''Reoviridae'' is a family of double-stranded RNA viruses. Member viruses have a wide host range, including vertebrates, invertebrates, plants, protists and fungi. They lack lipid envelopes and package their segmented genome within multi-layered capsids. Lack of a lipid envelope has allowed three-dimensional structures of these large complex viruses (diameter ∼60–100 nm) to be obtained, revealing a structural and likely evolutionary relationship to the cystovirus family of bacteriophage. There are currently 97 species in this family, divided among 15 genera in two subfamilies. Reoviruses can affect the gastrointestinal system (such as rotaviruses) and respiratory tract. The name "reo-" is an acronym for "''r''espiratory ''e''nteric ''o''rphan" viruses''.'' The term "orphan virus" refers to the fact that some of these viruses have been observed not associated with any known disease. Even though viruses in the family ''Reoviridae'' have more recently been identified with v ...
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Aquareovirus
''Aquareovirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Fish, shellfish, and crustacean species serve as natural hosts. Aquareoviruses in general have low or no pathogenicity for fish. However, some cause hemorrhagic disease, hepatitis and pancreatitis. Grass carp hemorrhage virus (causes hemorrhagic disease of grass carp) is the most pathogenic aquareovirus. There are seven species in this genus. Structure Aquareoviruses are non-enveloped, with a double capsid structure that has icosahedral In geometry, an icosahedron ( or ) is a polyhedron with 20 faces. The name comes and . The plural can be either "icosahedra" () or "icosahedrons". There are infinitely many non- similar shapes of icosahedra, some of them being more symmetrica ... geometries, and T=13, T=2 symmetry. The diameter is around 75 nm. Genome Aquareoviruses have double-stranded RNA genomes which are linear and segmented. The total g ...
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Cypovirus
''Cypovirus'', short for cytoplasmic polyhedrosis virus, is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Cypoviruses have only been isolated from insects. Diseases associated with this genus include chronic diarrhoea and pale blue iridescence in the guts of larvae. Sixteen species are placed in this genus. Cypoviruses structurally have muc in common with the more widely studied nucleopolyhedroviruses, a genus of arthropod viruses in the family ''Baculoviridae''. However, cypoviruses have an RNA genome and replicate in the cytoplasm of the infected cells, while nucleopolyhedroviruses have a DNA genome and replicate in the nucleus. Structure Viruses in the genus ''Cypovirus'' are nonenveloped, with icosahedral geometries, and T=2 symmetry. Cypoviruses have only a single capsid shell, which is similar to the orthoreovirus inner core. They exhibit striking capsid stability, which is fully capable of endogenous RNA transcrip ...
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Dinovernavirus
''Dinovernavirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Member Virus, viruses replicate in a variety of mosquito cell lines. The name is an abbreviation for ''d''ouble-stranded, ''i''nsect, ''nove''m (Latin for nine the number of genome segments), ''rna'' virus. There is one species in the genus: ''Aedes pseudoscutellaris reovirus''. Structure Viruses in ''Dinovernavirus'' are non-enveloped. Their capsid is turreted and single shelled with icosahedral geometries and T=2 symmetry. The diameter is around 49–50 nm. Genome Genomes are linear and segmented. There are nine segments which code for nine proteins. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits t ...
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Fijivirus
''Fijivirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae.'' Plants serve as natural hosts. Diseases associated with this genus include: galls (tumours) in infected plants and Fiji disease, with severe stunting, deformation and death. The group name derives from ''Fiji'' island the place where the first virus was isolated. There are nine species in this genus. Structure Fijivirus genome composition contains ten linear double-stranded RNA (dsRNA) and is carried within virus particles referred to as virions. The Fijivirus genome is constructed inside the virion and is non-enveloped. It contains two separate layers of capsids, an inner and an outer layer, which are constructed by proteins that shell the virus. The capsids are of icosahedral symmetry (T=2 for inner capsid, T=13 for outer capsid), and have an obvious round structure, which is on average 65–70 nm in diameter. Genomes are linear and segmented, around 4.5 ...
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Idnoreovirus
''Idnoreovirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Hymenoptera insects serve as natural hosts. The genus name is an acronym for ''i''nsect ''d''erived ''n''on ''o''ccluded reovirus. There are five species in this genus. Structure Viruses in genus ''Idnoreovirus'' are non-enveloped, with icosahedral geometries. The outer capsid has T=13 symmetry and the inner capsid has T=2 symmetry. The diameter is around 70 nm. Genomes are linear and segmented. They are around 27–30 kbp in total length. The genome codes for 11 proteins. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits the host cell by monopartite non-tubule guided viral movement. Hymonoptera insects serv ...
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Mycoreovirus
''Mycoreovirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Fungus, Fungi serve as natural hosts. Diseases associated with this genus include: hypovirulence of the fungal host. The name of the group derives from Ancient Greek ''myco'' which means fungus. There are three species in this genus. Structure Viruses in genus ''Mycoreovirus'' are Viral envelope, non-enveloped with Icosahedral symmetry, icosahedral geometries. The outer capsid has T=13 symmetry and the inner capsid has T=2 symmetry. The diameter is around 80 nm. Genomes are linear and segmented, and around 23 kbp in total length. The genome codes for 12 proteins. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The viru ...
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Oryzavirus
''Oryzavirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae'' and subfamily ''Spinareovirinae''. Member viruses infect plants and are transmitted by planthoppers. Diseases associated with this genus include: rice stunting, enations on veins of leaves and leaf sheaths, ragged leaves, and flower suppression. There are two species in this genus. Structure Viruses in ''Oryzavirus'' are non-enveloped, with icosahedral and Round geometries, and T=13, T=2 symmetry. The diameter is around 70 nm. Genomes are linear and segmented, segments are around 1162 to 3849 base pairs (total size around 26 kb). The genome codes for 12 proteins. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. The virus exits the host cell by monopartite non-tubule guided viral move ...
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Orthoreovirus
''Orthoreovirus'' is a genus of viruses, in the family ''Reoviridae'', in the subfamily ''Spinareovirinae''. Vertebrates serve as natural hosts. There are ten species in this genus. Diseases associated with this genus include mild upper respiratory tract disease, gastroenteritis, and biliary atresia. Mammalian orthoreovirus 3 (strain dearing-T3D) induces cell death preferentially in transformed cells and therefore displays inherent oncolytic properties. History The name "orthoreovirus" comes from the Greek word ''ortho'', meaning "straight" and the reovirus, which comes from taking the letters: R, E, and O from "respiratory enteric orphan virus". The Orthoreovirus was named an orphan virus because it was not known to be associated with any known disease. It was discovered in the early 1950s when it was isolated from the respiratory as well as gastrointestinal tracts of both sick and healthy individuals Classification ''Orthoreovirus'' is part of the family ''Reoviridae''. Its g ...
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Cryo-EM
Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution. This has attracted wide attention to the approach as an alternative to X-ray crystallography or NMR spectroscopy for macromolecular structure determination without the need for crystallization. In 2017, the Nobel Prize in Chemistry was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." ''Nature M ...
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