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Interleukin 17
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier ''et al.'' who isolated IL17A transcript from a rodent T-cell hybridoma. The protein encoded by ''IL17A'' is a founding member of IL-17 family (see below). IL17A protein exhibits a high homology with a viral IL-17-like protein () encoded in the genome of T-lymphotropic rhadinovirus ''Herpesvirus saimiri''. In rodents, IL-17A is often referred to as CTLA8. The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines. Acting as chemoattractants, these chemokines recruit the immun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Illinois's 17th Congressional District
The 17th congressional district of Illinois is represented by Democrat Cheri Bustos. It includes most of the northwestern portion of the state, with most of its population living on the Illinois side of the Quad Cities, as well as parts of Peoria and Rockford. The 17th congressional district has shifted northward after redistricting in 2012. It subsequently lost Quincy and Decatur, as well as its share of Springfield. It was generally thought that the redrawn map would allow the district to revert to the Democrats, who held it without interruption from 1983 to 2011. As expected, incumbent Representative Bobby Schilling was defeated, after serving only one term, by Democratic opponent Cheri Bustos in the 2012 election cycle, who has served since that election. It is one of the few Democratic-leaning districts that voted for Barack Obama and Donald Trump twice each. It is also one of seven districts that voted for Trump in the 2020 presidential election while being held by a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
