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Collaborative Study On The Genetics Of Alcoholism
The Collaborative Studies on the Genetics of Alcoholism (COGA) is an eleven-center research project in the United States designed to understand the genetic basis of alcoholism. Research is conducted at University of Connecticut, Indiana University, University of Iowa, SUNY Downstate Medical Center, Washington University in St. Louis, University of California at San Diego, Rutgers University, University of Texas Health Science Center at San Antonio, Virginia Commonwealth University, Icahn School of Medicine at Mount Sinai, and Howard University. Henri Begleiter and Theodore Reich were founding PI and Co-PI of COGA. Since 1991, COGA has interviewed more than 17,000 members of more than 2,200 families from around the United States, many of whom have been longitudinally assessed. Family members, including adults, children, and adolescents, have been carefully characterized across a variety of domains, including other alcohol and other substance-related phenotypes, co-occurring disord ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcoholism
Alcoholism is the continued drinking of alcohol despite it causing problems. Some definitions require evidence of dependence and withdrawal. Problematic use of alcohol has been mentioned in the earliest historical records. The World Health Organization (WHO) estimated there were 283 million people with alcohol use disorders worldwide . The term ''alcoholism'' was first coined in 1852, but ''alcoholism'' and ''alcoholic'' are considered stigmatizing and likely to discourage seeking treatment, so diagnostic terms such as ''alcohol use disorder'' and ''alcohol dependence'' are often used instead in a clinical context. Alcohol is addictive, and heavy long-term alcohol use results in many negative health and social consequences. It can damage all the organ systems, but especially affects the brain, heart, liver, pancreas, and immune system. Heavy alcohol usage can result in trouble sleeping, and severe cognitive issues like dementia, brain damage, or Wernicke–Kors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard University
Howard University is a private, historically black, federally chartered research university in Washington, D.C., United States. It is classified among "R1: Doctoral Universities – Very high research activity" and accredited by the Middle States Commission on Higher Education. Established in 1867, Howard is a nonsectarian institution located in the Shaw neighborhood. It offers undergraduate, graduate, and professional degrees in more than 120 programs. History 19th century Shortly after the end of the American Civil War, members of the First Congregational Society of Washington considered establishing a theological seminary for the education of black clergymen. Within a few weeks, the project expanded to include a provision for establishing a university. Within two years, the university consisted of the colleges of liberal arts and medicine. The new institution was named for General Oliver Otis Howard, a Civil War hero who was both the founder of the university an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Institutes In The United States
Medicine is the science and Praxis (process), practice of caring for patients, managing the Medical diagnosis, diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, and Health promotion, promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention (medical), prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, medical genetics, genetics, and medical technology to diagnosis (medical), diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, splint (medicine), external splints and traction, medical devices, biologic medical product, biologics, and Radiation (medicine), ionizing radiation, amongst others. Medicine has been practiced since Prehistoric medicine, prehistoric times, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Organizations
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Phenotypic trait, Trait inheritance and Molecular genetics, molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the Cell (bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Event-related Potential
An event-related potential (ERP) is the measured brain response that is the direct result of a specific sense, sensory, cognition, cognitive, or motor system, motor event. More formally, it is any stereotyped electrophysiology, electrophysiological response to a stimulus. The study of the brain in this way provides a Invasiveness of surgical procedures, noninvasive means of evaluating brain functioning. ERPs are measured by means of electroencephalography (EEG). The magnetoencephalography (MEG) equivalent of ERP is the ERF, or event-related field. Evoked potentials and induced potentials are subtypes of ERPs. History With the discovery of the electroencephalogram (EEG) in 1924, Hans Berger revealed that one could measure the electrical activity of the human brain by placing electrodes on the scalp and amplifying the signal. Changes in voltage can then be plotted over a period of time. He observed that the voltages could be influenced by external events that stimulated the sense ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Depression
Major depressive disorder (MDD), also known as clinical depression, is a mental disorder characterized by at least two weeks of pervasive low mood, low self-esteem, and loss of interest or pleasure in normally enjoyable activities. Introduced by a group of US clinicians in the mid-1970s, the term was adopted by the American Psychiatric Association for this symptom cluster under mood disorders in the 1980 version of the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM-III), and has become widely used since. The disorder causes the second-most years lived with disability, after lower back pain. The diagnosis of major depressive disorder is based on the person's reported experiences, behavior reported by family or friends, and a mental status examination. There is no laboratory test for the disorder, but testing may be done to rule out physical conditions that can cause similar symptoms. The most common time of onset is in a person's 20s, with females affe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antisocial Personality Disorder
Antisocial personality disorder (ASPD) is a personality disorder defined by a chronic pattern of behavior that disregards the rights and well-being of others. People with ASPD often exhibit behavior that conflicts with social norms, leading to issues with interpersonal relationships, employment, and legal matters. The condition generally manifests in childhood or early adolescence, with a high rate of associated conduct problems and a tendency for symptoms to peak in late adolescence and early adulthood. The prognosis for ASPD is complex, with high variability in outcomes. Individuals with severe ASPD symptoms may have difficulty forming stable relationships, maintaining employment, and avoiding criminal behavior, resulting in higher rates of divorce, unemployment, homelessness, and incarceration. In extreme cases, ASPD may lead to violent or criminal behaviors, often escalating in early adulthood. Research indicates that individuals with ASPD have an elevated risk of suicide, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is the active ingredient in alcoholic drinks such as beer, wine, and distilled spirits (hard liquor). Alcohol is a central nervous system (CNS) depressant, decreasing Action potential, electrical activity of neurons in the brain, which causes the characteristic effects of alcohol intoxication ("drunkenness"). Among other effects, alcohol produces euphoria, anxiolytic, decreased anxiety, increased sociability, sedation, and impairment of cognitive, memory, motor control, motor, and sense, sensory function. Alcohol has a variety of adverse effects. Short-term effects of alcohol consumption, Short-term adverse effects include generalized impairment of neurocognitive function, dizziness, nausea, vomiting, and symptoms of hangover. Alcohol is addiction, addictive and can result in alcohol use disorder, Substance dependence, dependence, and Alcohol withdrawal syndrome, withdrawal upon cessation. The long-term effects of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Henri Begleiter
Henri Begleiter (September 11, 1935 in Nimes, France – April 6, 2006 in Long Island, NY) was a neurophysiologist and Distinguished Professor of Psychiatry and Neuroscience at SUNY Downstate Medical Center in Brooklyn Brooklyn is a Boroughs of New York City, borough of New York City located at the westernmost end of Long Island in the New York (state), State of New York. Formerly an independent city, the borough is coextensive with Kings County, one of twelv .... He was a leader in the nascent field of biomedical alcohol research in the 1970s, postulating alcoholism as a brain disorder. He founded and headed the world-renowned Neurodynamics Laboratory at SUNY Downstate Medical Center, Brooklyn, which has been renamed in 2007 into the 'Henri Begleiter Neurodynamics Laboratory'. The highlights of Begleiter’s career include the ground breaking finding published in Science that some neurophysiological anomalies in alcoholics were already present in their young offspring ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Icahn School Of Medicine At Mount Sinai
The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City, New York, United States. The school is the academic teaching arm of the Mount Sinai Health System, which manages eight hospital campuses in the New York metropolitan area, including Mount Sinai Hospital and the New York Eye and Ear Infirmary. The school is a teaching hospital first conceived in 1958. Due to simultaneous expansion initiatives at the hospital, classes did not begin until 1968. Its name was changed to The Icahn School of Medicine at Mount Sinai in 2012, after a $200 million grant from businessman Carl Icahn. Post-graduate academics are focused on biomedical sciences and public health. Its campus is located on Manhattan’s Upper East Side, between Fifth and Madison Avenues, stretching from East 98th Street to East 102nd Street. History As Mount Sinai School of Medicine The first official proposa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Connecticut
The University of Connecticut (UConn) is a public land-grant research university system with its main campus in Storrs, Connecticut, United States. It was founded in 1881 as the Storrs Agricultural School, named after two benefactors. In 1893, the school became a public land grant college, then took its current name in 1939. Over the following decade, social work, nursing, and graduate programs were established. During the 1960s, UConn Health was established for new medical and dental schools. UConn is accredited by the New England Commission of Higher Education. With more than 32,000 students, the University of Connecticut is the largest university in Connecticut by enrollment. The university is classified among "R1: Doctoral Universities – Very high research activity". UConn is one of the founding institutions of the Hartford- Springfield regional economic and cultural partnership alliance known as New England's Knowledge Corridor. UConn was the second U.S. university i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginia Commonwealth University
Virginia Commonwealth University (VCU) is a Public university, public research university in Richmond, Virginia, United States. VCU was founded in 1838 as the medical department of Hampden–Sydney College, becoming the Medical College of Virginia in 1854. In 1968, the Virginia General Assembly merged MCV with the Richmond Professional Institute, founded in 1917, to create Virginia Commonwealth University. In 2022, more than 28,000 students pursued 217 degree and certificate programs through VCU's 11 schools and three colleges. The VCU Health System supports health care education, research, and patient care. It was the only school in the South to have graduated a class every year during the American Civil War. VCU had a record $506 million in sponsored research funding in the fiscal year 2024 and is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". VCU's athletic teams compete in NCAA Divisio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
