Chlorsulfuron Synthesis
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Chlorsulfuron Synthesis
Chlorsulfuron is an ALS (acetolactate synthase) inhibitor herbicide, and is a sulfonylurea compound. It was discovered by George Levitt in February 1976 while working at DuPont, which was the patent assignee. Brand names Originally introduced in 1982 under the brand name Glean by DuPont, later also as Telar, in North America. Chemistry The first synthesis of chlorsulfuron was disclosed in a patent filed by DuPont in 1977. 2-Chlorobenzenesulfonyl isocyanate was condensed with 2-amino-4-methoxy-6-methyl-1,3,5-triazine to form the sulfonylurea product. : Mode of action Chlorsulfuron is an herbicide of the acetolactate synthase inhibitor (ALS inhibitor) class, HRAC (Herbicide Resistance Action Committee) group 2 (legacy HRAC Group B). Efficacy ''Triticum aestivum'' is naturally resistant via aryl hydroxylation then conjugation with glucose compounds into non-herbicidal conjugates. Widespread weed resistance to chlorsulfuron has been found across North America and around ...
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Acetolactate Synthase Inhibitor
The acetolactate synthase (ALS) enzyme (also known as acetohydroxy acid or acetohydroxyacid synthase, abbr. AHAS) is a protein found in plants and micro-organisms. ALS catalyzes the first step in the synthesis of the branched-chain amino acids ( valine, leucine, and isoleucine). A human protein of yet unknown function, sharing some sequence similarity with bacterial ALS, is encoded by the ILVBL (ilvB-like) gene. Structure Gene Human ILVBL gene has 17 exons resides on chromosome 19 at q13.1. Protein The catalytic peptide of ALS in ''Arabidopsis thaliana'' (mouse-eared cress) is a chloroplastic protein consisting of 670 residues, the last 615 of which form the active form. Three main domains are found, with two thiamine pyrophosphate sandwiching a DHS-like NAD/FAD-binding domain. In SCOP assignment, these subunits are named d1yhya1, d1yhya2, and d1yhya3 from the N-terminal to the C-termianl. The structure of acetolactate synthase that was used for the picture on this page ...
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Stellaria Media
''Stellaria media'', chickweed, is an annual and perennial flowering plant in the family Caryophyllaceae.Fernald, M. L. 1950. “Gray's Manual of Botany”. Eight Edition. American Book Company, New York, NY. 1632 pp. It is native to Eurasia and naturalized throughout the world. This species is used as a cooling herbal remedy, and grown as a vegetable crop and ground cover for both human and poultry consumption. It is sometimes called common chickweed to distinguish it from other plants called chickweed. Other common names include chickenwort, craches, maruns, and winterweed. The plant germinates in autumn or late winter, then forms large mats of foliage. Description This species is an annual in colder climates, becoming evergreen and perennial in warmer zones, with weak slender stems, up to . Plants are sparsely hairy. ''Stellaria media'' has one line of fine hairs on the stem. The leaves are oval and opposite, the lower ones with stalks. Flowers are white and small with ...
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Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ...
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Biological Sciences
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the ...
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